Phosphatase Modulators PDF Download
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Author | : José Luis Millán |
Publisher | : Humana Press |
Total Pages | : 315 |
Release | : 2013-07-17 |
Genre | : Medical |
ISBN | : 9781627035637 |
Download Phosphatase Modulators Book in PDF, ePub and Kindle
Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Author | : José Luis Millán |
Publisher | : Humana |
Total Pages | : 0 |
Release | : 2016-08-23 |
Genre | : Medical |
ISBN | : 9781493960316 |
Download Phosphatase Modulators Book in PDF, ePub and Kindle
Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Author | : Helena Macut |
Publisher | : |
Total Pages | : |
Release | : 2019 |
Genre | : |
ISBN | : |
Download Development of Allosteric PFKFB3 Phosphatase Modulators Book in PDF, ePub and Kindle
Author | : Maja Köhn |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
Download Miklós Bodanszky Award Lecture: Advances in the Selective Targeting of Protein Phosphatase-1 and Phosphatase-2A with Peptides Book in PDF, ePub and Kindle
Abstract: Protein phosphatase-1 and phosphatase-2A are two ubiquitously expressed enzymes known to catalyze the majority of dephosphorylation reactions on serine and threonine inside cells. They play roles in most cellular processes and are tightly regulated by regulatory subunits in holoenzymes. Their misregulation and malfunction contribute to disease development and progression, such as in cancer, diabetes, viral infections, and neurological as well as heart diseases. Therefore, targeting these phosphatases for therapeutic use would be highly desirable; however, their complex regulation and high conservation of the active site have been major hurdles for selectively targeting them in the past. In the last decade, new approaches have been developed to overcome these hurdles and have strongly revived the field. I will focus here on peptide-based approaches, which contributed to showing that these phosphatases can be targeted selectively and aided in rethinking the design of selective phosphatase modulators. Finally, I will give a perspective on www.depod.org, the human dephosphorylation database, and how it can aid phosphatase modulator design. © 2017 The Authors. Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd
Author | : Yvet Elisabeth Noordman |
Publisher | : |
Total Pages | : 0 |
Release | : 2008 |
Genre | : |
ISBN | : 9789090226729 |
Download Protein Tyrosine Phosphatase PTPRR Isoforms: Modulators of Neuronal Growth Factor Signalling Book in PDF, ePub and Kindle
Author | : Judith Weyershäuser |
Publisher | : |
Total Pages | : 0 |
Release | : 2022 |
Genre | : |
ISBN | : |
Download Characterisation and Modulation of the Phosphatase Activity of Phosphatase of Regenerating Liver-3 (PRL-3) and SH2 Containing Protein Tyrosine Phosphatase 2 (SHP2) Book in PDF, ePub and Kindle
Author | : Anushka Christobel Wickramaratne |
Publisher | : |
Total Pages | : 0 |
Release | : 2021 |
Genre | : |
ISBN | : |
Download Modulation of Nocturnin Phosphatase Activity Through the Disordered Amino Terminus Book in PDF, ePub and Kindle
Author | : Birgit Höger |
Publisher | : |
Total Pages | : |
Release | : 2016 |
Genre | : |
ISBN | : |
Download Chemical and Biochemical Modulation of PRL-3 Phosphatase Activity Book in PDF, ePub and Kindle
Author | : Edward A. Dennis |
Publisher | : Academic Press |
Total Pages | : 603 |
Release | : 2011-04-04 |
Genre | : Science |
ISBN | : 0123838630 |
Download Transduction Mechanisms in Cellular Signaling Book in PDF, ePub and Kindle
Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
Author | : Ralph A. Bradshaw |
Publisher | : Academic Press |
Total Pages | : 3188 |
Release | : 2009-11-03 |
Genre | : Science |
ISBN | : 0080920918 |
Download Handbook of Cell Signaling Book in PDF, ePub and Kindle
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field