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Pharmaceutical Microscopy

Pharmaceutical Microscopy
Author: Robert Allen Carlton
Publisher: Springer Science & Business Media
Total Pages: 333
Release: 2011-05-04
Genre: Science
ISBN: 1441988319
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Microscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of techniques together with numerous practical applications of importance in drug development. The first section presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification. Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists. Consequently, each section has exercises designed to teach the reader how to use and apply the techniques in the book. Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises. Provides comprehensive coverage of key microscopy techniques used in pharmaceutical development Helps the reader to solve specific problems in pharmaceutical quality assurance Oriented and designed for pharmaceutical scientists who need to use microscopy but are not expert microscopists Includes a large number of practical exercises to give the reader hands-on experience with the techniques Written by an author with 21 years of experience in the pharmaceutical industry

The Microscope in Medicine

The Microscope in Medicine
Author: Lionel Smith Beale
Publisher:
Total Pages: 756
Release: 1878
Genre: Anatomy, Pathological
ISBN:
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Light microscopic techniques in biology and medicine

Light microscopic techniques in biology and medicine
Author: J. James
Publisher: Springer Science & Business Media
Total Pages: 345
Release: 2012-12-06
Genre: Medical
ISBN: 9401014140
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Up to about twenty-five years ago, virtually the entire field of microscopy could be overseen and even practized by any active research worker. The rapid evolution which microscopy in its broadest sense has since undergone and which has contributed greatly to our insight in many fields of biological science and medicine has, however, lead to a progressive specialisation. Both experienced investigators in clinical and biological laboratories and post graduate students, confronted with a limited number of microscopic tech niques in their daily research work, have increasing difficulty in keeping (or obtaining) a general idea of the many time-honoured and new possibilities which microscopy has to offer. This book has been written with the aim of presenting general informa tion on light microscopic techniques, at a level somewhere in between booklets like those provided by microscope manufacturers (which are often too much focussed on the production program of a particular make) and very advanced treatises with a thorough mathematical treatment of all phenomena concerned. The physically oriented texts moreover often do not sufficiently take into account the practical situation in a medical or biolog ical laboratory; on the other hand, the value of really understanding what one is doing in using a microscopic technique is often underestimated. At tempt has been made, therefore, to present sufficient background informa tion necessary for a rational application of the different microscopical tech niques in their mutual relationship.

Powdered Crude Drug Microscopy of Leaves and Barks

Powdered Crude Drug Microscopy of Leaves and Barks
Author: Vidhu Aeri
Publisher: Elsevier
Total Pages: 334
Release: 2019-11-22
Genre: Science
ISBN: 0128182253
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Powdered Crude Drug Microscopy of Leaves and Barks investigates various microscopic techniques used in the examination of structural and cellular features in order to determine their botanical origin. These methods are useful in identifying species with similar morphological characters. Today, there is a variety of methods available to authenticate herbal drugs, ranging from simple morphological examination to physical and chemical analysis, and DNA molecular biology. Due to cost, powder microscopy is the most practical method for primary authentication. Botanical microscopy is a unique, valuable, rapid and cost-effective assessment tool, and plays an important role in the authentication and assessment of medicinal plants. This book is an essential resource for students and researchers involved in the study of plants and natural products, as well as professionals in industries manufacturing plant-based products for use during quality control and assurance steps. Provides a fundamental understanding of the macroscopic and microscopic characteristics of crude drugs, including photographs of herbs in their raw and powder forms. Presents specific characteristics and sub-features for identifying barks and leaves, including stone cells, calcium oxalate crystals, starch grains, medullary rays, fibres, sclereids, cork, isolated oil cells, tubular lactiferous canals, phloem parenchyma, masses, rhytidoma, parenchyma and secretory canals. Includes specific characteristics for identifying leaves, such as epidermis, stomata, trichomes, calcium oxalate crystals, fibres, cell contents, cystoliths, lamina, starch grains, tracheids, lactiferous canals and xylem vessels. Demonstrates how the specificity of characteristics for a particular bark or leaf in powder form can lead to its authentication. Features standard operating protocols for preparation of slides and lab samples using industrially operated grinders to observe general as well as distinguishing microscopical characters of barks and leaves.

Solving Problems with Microscopy

Solving Problems with Microscopy
Author: John A. Reffner
Publisher: John Wiley & Sons
Total Pages: 325
Release: 2023-11-10
Genre: Science
ISBN: 1119788226
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Solving Problems with Microscopy Comprehensive resource, based on real case examples, on the ability of the microscope for solving problems This book takes a “why to” rather than the common “how to” approach to demonstrate the capabilities of microscopy to solve problems. It provides entertaining and informative case examples and lessons regarding the unique value the microscope brings to problem solving by experienced scientists in various industries, including criminal and civil forensic science, manufacturing, environmental science, pharmaceutical science, cultural heritage, and biological sciences. Sample topics covered in this learning resource include: History of problem solving with microscopy Fortune favors the prepared mind The value of multiple associations The importance of context Knowing your limitations (i.e. knowing what you don’t know) Microscopists and other professional scientists who use microscopy can harness the information in this book to make better and more informed decisions by improving their problem-solving strategies and processes.

Indian Herbal Drug Microscopy

Indian Herbal Drug Microscopy
Author: Shailendra S. Gurav
Publisher: Springer Science & Business Media
Total Pages: 220
Release: 2013-11-20
Genre: Science
ISBN: 1461495156
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Adulteration and misidentification of herbal drugs can cause serious health problems to consumers. The first step in quality control of medicinal plants is ensuring the authenticity of the desired species for intended use, with anatomical study playing a critical role in identifying and authenticating medicinal plants. A product of numerous years of experience and research, Indian Herbal Drug Microscopy is a vital resource for identifying and evaluating Indian medicinal plants. Comprised of four concise and comprehensive chapters, the book presents stepwise procedures for sectioning of plant material, histo-chemical staining techniques, and the anatomy of forty well-known and medicinally important plants, including Arjuna, Ashoka, Ashwagandha, Cinchona, Cinnamon, Ginger, Kurchi, Rauwolfia, Turmeric, Tulsi, and Vasaka. The book is also supplemented with color photographs and hand-drawn microscopic images. Written by authorities in the field, Indian Herbal Drug Microscopy is a valuable guide for herbal drug microscopy of Indian medicinal plants.

MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES

MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES
Author: Mrs. Mitali Yogesh Patil
Publisher: JEC PUBLICATION
Total Pages: 229
Release:
Genre: Medical
ISBN: 9358504951
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In the dynamic realm of pharmaceutical sciences, this project explores "Modern Pharmaceutical Analytical Techniques," delving into cutting-edge methodologies crucial for ensuring the quality and efficacy of drugs. From spectroscopy to advanced technologies like metabolomics, each chapter demystifies the application and significance of these techniques. Bridging academia and industry, this work aims to be a practical guide, underlining the realworld implications of these tools. Gratitude is extended to mentors, colleagues, and institutions, as this concise exploration seeks to serve students, researchers, and professionals navigating the ever-evolving landscape of pharmaceutical analysis.

Pharmaceutical Analysis

Pharmaceutical Analysis
Author: David C Lee
Publisher: John Wiley & Sons
Total Pages: 384
Release: 2009-02-12
Genre: Science
ISBN: 1405172991
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The use of analytical sciences in the discovery, development andmanufacture of pharmaceuticals is wide-ranging. From the analysisof minute amounts of complex biological materials to the qualitycontrol of the final dosage form, the use of analytical technologycovers an immense range of techniques and disciplines. This book concentrates on the analytical aspects of drugdevelopment and manufacture, focusing on the analysis of the activeingredient or drug substance. It provides those joining theindustry or other areas of pharmaceutical research with a source ofreference to a broad range of techniques and their applications,allowing them to choose the most appropriate analytical techniquefor a particular purpose. The volume is directed at analytical chemists, industrialpharmacists, organic chemists, pharmaceutical chemists andbiochemists.

Pharmaco-Imaging in Drug and Biologics Development

Pharmaco-Imaging in Drug and Biologics Development
Author: Brian R. Moyer
Publisher: Springer Science & Business Media
Total Pages: 413
Release: 2013-11-08
Genre: Medical
ISBN: 146148247X
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The volume aim to be a comprehensive overview of the drug and biologic development process that is often called “the valley of death” (pre-IND through approval) where high costs of studies and high rates of product failure are part of the drug development landscape. Imaging tools can serve in this period by adding high value data, the images and the kinetic information they can provide, and cost-effective development alternative tools which potentially improve pivotal study designs. Imaging may identify safety issues early such as unwanted organ or tissue distributions, and then can serve advanced development with added certainty of a drug or biologic’s success to senior corporate management and investors. There are numerous textbooks, reference texts and treatises on medical imaging technologies, teaching tools on medical cases and physics books on the science of detector and computer interface systems. Rarely, in each of these are examples of medical imaging protocols and animal models of disease i.e. a text on methodology in drug development is currently unavailable.