Perspectives in Medicinal Chemistry
Author | : Bernard Testa |
Publisher | : |
Total Pages | : 644 |
Release | : 1993 |
Genre | : Chemotherapy |
ISBN | : 9783906390048 |
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Author | : Bernard Testa |
Publisher | : |
Total Pages | : 644 |
Release | : 1993 |
Genre | : Chemotherapy |
ISBN | : 9783906390048 |
Author | : Bernard Testa |
Publisher | : Wiley-VCH |
Total Pages | : 672 |
Release | : 1993-03-25 |
Genre | : Science |
ISBN | : |
A broad overview of the latest advances in medicinal chemistry. Emphasis is placed on - drug design - new therapeutic agents - treatment of major diseases, such as AIDS and malaria. The book discusses recently discovered targets for drug action. It also takes a look at the theoretical and experimental tools which have fostered our understanding of the molecular mechanisms of drug action.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : |
Genre | : |
ISBN | : |
Author | : Jie Jack Li |
Publisher | : John Wiley & Sons |
Total Pages | : 572 |
Release | : 2013-04-03 |
Genre | : Medical |
ISBN | : 111835446X |
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Author | : Alessandro Pratesi |
Publisher | : Frontiers Media SA |
Total Pages | : 84 |
Release | : 2021-05-10 |
Genre | : Science |
ISBN | : 2889667510 |
Author | : Jie Jack Li |
Publisher | : John Wiley & Sons |
Total Pages | : 416 |
Release | : 2020-06-29 |
Genre | : Medical |
ISBN | : 1119607302 |
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Author | : Vivekkumar K Redasani |
Publisher | : Academic Press |
Total Pages | : 84 |
Release | : 2015-07-07 |
Genre | : Science |
ISBN | : 0128035579 |
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference. Offers unique, detailed overview of Prodrug research and literature Provides detailed chemical structures Includes Prodrug listing by therapeutic area
Author | : Werngard Czechtizky |
Publisher | : John Wiley & Sons |
Total Pages | : 546 |
Release | : 2015-11-02 |
Genre | : Science |
ISBN | : 1118771605 |
Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting
Author | : John Bodenhan Taylor |
Publisher | : |
Total Pages | : 896 |
Release | : 2007 |
Genre | : Business & Economics |
ISBN | : |
This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.
Author | : Norma K Dunlap |
Publisher | : Garland Science |
Total Pages | : 375 |
Release | : 2018-04-17 |
Genre | : Medical |
ISBN | : 1351586211 |
Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.