Pathway Analysis For Drug Discovery PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Pathway Analysis For Drug Discovery PDF full book. Access full book title Pathway Analysis For Drug Discovery.
| Author | : Anton Yuryev |
| Publisher | : John Wiley & Sons |
| Total Pages | : 332 |
| Release | : 2008-09-17 |
| Genre | : Science |
| ISBN | : 0470399260 |
Download Pathway Analysis for Drug Discovery Book in PDF, ePub and Kindle
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.
| Author | : Anastasios Bezerianos |
| Publisher | : Springer |
| Total Pages | : 96 |
| Release | : 2017-03-09 |
| Genre | : Computers |
| ISBN | : 3319538683 |
Download Computational Methods for Processing and Analysis of Biological Pathways Book in PDF, ePub and Kindle
This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.
| Author | : Richard S. Larson |
| Publisher | : Humana Press |
| Total Pages | : 374 |
| Release | : 2016-08-23 |
| Genre | : Science |
| ISBN | : 9781493959297 |
Download Bioinformatics and Drug Discovery Book in PDF, ePub and Kindle
Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.
| Author | : Rishi Raj Gupta |
| Publisher | : |
| Total Pages | : 404 |
| Release | : 2006 |
| Genre | : |
| ISBN | : |
Download A Systems Engineering Approach for Genetic Pathway Analysis and Towards In-silico Drug Development Book in PDF, ePub and Kindle
| Author | : Yuri Nikolsky |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2009-07-28 |
| Genre | : Science |
| ISBN | : 9781607611745 |
Download Protein Networks and Pathway Analysis Book in PDF, ePub and Kindle
From the beginning of the OMICs biology era, science has been pursuing the reduction of the complex "genome-wide" assays in order to understand the essential biology that lies beneath it. In Protein Networks and Pathway Analysis, expert practitioners present a compilation of methods of functional data analysis, often referred to as "systems biology," and its applications in drug discovery, medicine and basic disease research. The volume is divided into three convenient sections, covering the elucidation of protein, compound and gene interactions, analytical tools, including networks, interactome and ontologies, and applications of functional analysis. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides detailed descriptions and hands-on implementation advice. Authoritative and cutting-edge, Protein Networks and Pathway Analysis presents both "wet lab" experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field.
| Author | : Andrew Carmen |
| Publisher | : CRC Press |
| Total Pages | : 420 |
| Release | : 2006-10-19 |
| Genre | : Medical |
| ISBN | : 1420015605 |
Download Biochips as Pathways to Drug Discovery Book in PDF, ePub and Kindle
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as bioc
| Author | : Tatiana V. Tatarinova |
| Publisher | : Humana Press |
| Total Pages | : 509 |
| Release | : 2017-08-29 |
| Genre | : Science |
| ISBN | : 9781493970254 |
Download Biological Networks and Pathway Analysis Book in PDF, ePub and Kindle
In this volume, expert practitioners present a compilation of methods of functional data analysis (often referred to as “systems biology”) and its applications in drug discovery, medicine, and basic disease research. It covers such important issues as the elucidation of protein, compound and gene interactions, as well as analytical tools, including networks, interactome and ontologies, and clinical applications of functional analysis. As a volume in the highly successful Methods in Molecular Biology series, this work provides detailed description and hands-on implementation advice. Reputable, comprehensive, and cutting-edge, Biological Networks and Pathway Analysis presents both “wet lab” experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field.
| Author | : Daniel L. Young |
| Publisher | : John Wiley & Sons |
| Total Pages | : 398 |
| Release | : 2011-10-18 |
| Genre | : Medical |
| ISBN | : 0470261234 |
Download Systems Biology in Drug Discovery and Development Book in PDF, ePub and Kindle
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 217 |
| Release | : 2007-10-05 |
| Genre | : Nature |
| ISBN | : 0309109922 |
Download Toxicity Testing in the 21st Century Book in PDF, ePub and Kindle
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
| Author | : Marcus T. Scotti |
| Publisher | : Springer Nature |
| Total Pages | : 266 |
| Release | : 2022-05-17 |
| Genre | : Medical |
| ISBN | : 3030958957 |
Download Drug Target Selection and Validation Book in PDF, ePub and Kindle
The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
