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Parasite Genomics Protocols

Parasite Genomics Protocols
Author: Sara E. Melville
Publisher: Springer Science & Business Media
Total Pages: 454
Release: 2008-02-02
Genre: Science
ISBN: 1592597939

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Parasitic diseases remain a major health problem throughout the world, for both humans and animals. For many of us, our technologically advanced lifestyle has decreased the prevalence and transmission of parasitic diseases, but for the majority of the world’s population, they are ever present in homes, domestic animals, food, or the environment. The study of parasites and parasitic disease has a long and distinguished history. In some cases, it has been driven by the great importance of the presence of the parasite to the community, for example, those that affect our livestock. In other cases, it is clear that applied research has suffered for lack of funding because the parasite affects people with few resources, such as the rural poor in resource-poor countries. These instances include the so-called “neglected diseases,” as defined by the World Health Organization (WHO). Parasites have complicated life cycles, and a thorough understanding of the unique characteristics of a particular parasite species is vital in attempts to avoid, prevent, or cure infection or to alleviate symptoms. Of course, the biological characteristics that each parasite has developed to aid survival and transmission, to avoid destruction by the immune system, and to adapt to a changing environment are of lasting fascination to basic biologists as well. The elegance of these biological systems has ensured that the study of protozoan and metazoan parasites also remains an active field of research in countries where the diseases are not a threat to the population.


Parasite Genomics

Parasite Genomics
Author: Luis M. de Pablos
Publisher: Humana
Total Pages: 336
Release: 2021-07-28
Genre: Medical
ISBN: 9781071616802

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This detailed book provides a comprehensive series of innovative research techniques and methodologies applied to the parasite genomics research area, all applying different approaches to analyzing parasite genomes and furthering the study of genetic complexity and the mechanisms of regulation. Beginning with chapters on novel sequencing and the bioinformatics pipeline, the volume continues by exploring diagnostic approaches using genomic tools, host-parasite interactions, as well as the genomics of parasite-derived extracellular vesicles. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Parasite Genomics: Methods and Protocols creates a detailed picture of genomic approaches for researchers seeking a better understanding of characterizing parasite nucleic acid content.


Parasite Genomics

Parasite Genomics
Author: Luis M. de Pablos
Publisher:
Total Pages:
Release: 2021
Genre: Electronic books
ISBN: 9781071616819

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This detailed book provides a comprehensive series of innovative research techniques and methodologies applied to the parasite genomics research area, all applying different approaches to analyzing parasite genomes and furthering the study of genetic complexity and the mechanisms of regulation. Beginning with chapters on novel sequencing and the bioinformatics pipeline, the volume continues by exploring diagnostic approaches using genomic tools, host-parasite interactions, as well as the genomics of parasite-derived extracellular vesicles. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Parasite Genomics: Methods and Protocols creates a detailed picture of genomic approaches for researchers seeking a better understanding of characterizing parasite nucleic acid content.


Comparative Genomics in Neglected Human Parasites

Comparative Genomics in Neglected Human Parasites
Author: César López-Camarillo
Publisher: Nova Science Publishers
Total Pages: 0
Release: 2013
Genre: Genomics
ISBN: 9781624178740

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To date, parasite diseases still affect millions of people world-wide, mainly in developing countries. The recent sequencing of parasite genomes opened a new era in parasitology research since the acquisition of new genomic data, providing a useful tool to analyse and compare gene structure, location and characteristics from different species to study evolution and gene function. This book is a collection of the recent findings of international experts in modern parasitology, computational biology, evolutionary biology, and genetics. It includes specific data on the current knowledge and understanding of genome organisation, dynamic and function for Plasmodium falciparum, Trypanosoma spp., Leishmania spp., Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica and Microsporidium, which represent the main causes of parasitic infections in humans. This book will be an essential reference for all parasitologists and scientists, as well as researchers, postdoctoral fellows and graduate students in computational biology, evolutionary biology, and genetics.


Molecular Parasitology

Molecular Parasitology
Author: Julia Walochnik
Publisher: Springer
Total Pages: 547
Release: 2016-10-20
Genre: Medical
ISBN: 3709114160

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In the past years, genome projects for numerous human parasites have been completed and now allow first in depth comparisons and evolutionary conclusions. The genomes of parasites reflect the coevolution with their host, metabolic capacities depending on their respective habitat in the host. Gut parasites usually have an anaerobic metabolism, while blood parasites have an aerobic metabolism, intracellular parasites escape the immune system, while extracellular parasites evade the immune system, usually by antigenic variation. Comprehensive genome data now being available allow us to address profound scientific questions, such as which traits enable the parasite to survive in the human host, which to cause disease and which can be used as drug targets. This book intends to give an overview of the state of knowledge on “the molecules” of protozoan parasites – on their genomes, proteomes, glycomes and lipidomes.


Novel Frontiers in Helminth Genomics

Novel Frontiers in Helminth Genomics
Author: Jose F. Tort
Publisher: Frontiers Media SA
Total Pages: 169
Release: 2020-10-12
Genre: Medical
ISBN: 2889660702

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.


Malaria Parasites

Malaria Parasites
Author: Andrew P. Waters
Publisher: Caister Academic Press Limited
Total Pages: 578
Release: 2004
Genre: Medical
ISBN:

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The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.


Exploring Parasite Genomes

Exploring Parasite Genomes
Author: David Rollinson
Publisher: Cambridge University Press
Total Pages: 92
Release: 1999-12-09
Genre: Science
ISBN: 9780521775748

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Summarises the current state of various parasite genome projects and the bioinformatics of parasite genome analysis.


Anaerobic Parasitic Protozoa

Anaerobic Parasitic Protozoa
Author: C. Graham Clark
Publisher: Caister Academic Press Limited
Total Pages: 0
Release: 2010
Genre: Science
ISBN: 9781904455615

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In this book, internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of Entamoeba histolytica, Trichomonas vaginalis, Giardia and other diplomonads; the cytoskeletons of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis; genomic analyses and manipulation of gene expression in Entamoeba histolytica; nuclear and chromosomal structure and replication in Giardia; and the mitochondrion-like organelles of a fourth anaerobe, Blastocystis. --


Malaria Parasites

Malaria Parasites
Author: Jane M. Carlton
Publisher: Caister Academic Press Limited
Total Pages: 0
Release: 2013
Genre: Medical
ISBN: 9781908230072

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This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area.