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Principles of Osteoimmunology

Principles of Osteoimmunology
Author: Peter Pietschmann
Publisher: Springer
Total Pages: 331
Release: 2016-08-18
Genre: Medical
ISBN: 331934238X

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This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.


Osteoimmunology: Molecular Mechanisms and Clinical Applications

Osteoimmunology: Molecular Mechanisms and Clinical Applications
Author: Melonie Armstrong
Publisher: Foster Academics
Total Pages: 0
Release: 2023-09-19
Genre: Medical
ISBN: 9781646466054

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Osteoimmunology refers to an interdisciplinary research field that combines the field of immunology and osteology. It focuses on the potential treatments and mechanisms associated with bone related diseases, such as rheumatoid arthritis, periodontitis and osteoporosis that are caused by or linked with failure of the immune system. Receptor activator of nuclear factor kappaB ligand (RANKL) is the prime regulator of osteoclastogenesis. It is known to be responsible for the increased activation of osteoclasts, such as direct activation of T cells and indirect increase in the expression of RANKL, and consequently promoting osteoclastic activity. Osteoblasts have significance in the maintenance of the hematopoietic stem cell. Furthermore, they are also relevant in the development of lymphocytes, along with immune cell functions in the development of osteoclast and osteoblast. This book elucidates the concepts and innovative models around prospective developments with respect to osteoimmunology. Also included herein is a detailed explanation of the molecular mechanisms and clinical applications of this field. Those with an interest in this field would find this book helpful.


Osteoimmunology

Osteoimmunology
Author: Joseph Lorenzo
Publisher: Academic Press
Total Pages: 489
Release: 2010-09-24
Genre: Medical
ISBN: 0123756715

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Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact. Presents a comprehensive, translational source for all aspects of osteoimmunology in one reference work Experts in bone biology and immunology (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentations by bone biologists of the cellular and molecular mechanisms underlying bone cell development leading to bone and immunological diseases such as Lupus Clear presentations by immunologists of how immune cells develop and how the immune system plays a role in bone diseases like osteoporosis and arthritis


Osteoimmunology

Osteoimmunology
Author: Joseph Lorenzo
Publisher: Academic Press
Total Pages: 380
Release: 2015-09-23
Genre: Medical
ISBN: 0128006277

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Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis. Explains the intricate interaction between the immune system and bone Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems


Handbook of Chitin and Chitosan

Handbook of Chitin and Chitosan
Author: Sabu Thomas
Publisher: Elsevier
Total Pages: 859
Release: 2020-07-22
Genre: Science
ISBN: 0128179678

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The Handbook of Chitin and Chitosan: Chitin and Chitosan Based Polymer Materials for Various Applications, Volume Three, is a must-read for polymer chemists, physicists and engineers interested in the development of ecofriendly micro and nanostructured functional materials based on chitin and their various applications. The book addresses their isolation, preparation and properties and their composites, nanomaterials, manufacturing and characterizations. This is the third of three volumes in a series that contains the latest on the major applications of chitin and chitosan based IPN’s, blends, gels, composites and nanocomposites, including environmental remediation, biomedical applications and smart material applications. Provides a comprehensive overview of Chitin and Chitosan materials, from their synthesis and nanomaterials, to their manufacture and applications Volume Three focuses on the applications of Chitin and Chitosan Includes contributions from leading researchers across the globe and from industry, academia, government and private research institutions Highlights current status and future opportunities


The Bioarchaeology of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease
Author: Megan B. Brickley
Publisher: Academic Press
Total Pages: 329
Release: 2020-07-30
Genre: Law
ISBN: 0081022786

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The Bioarchaeology of Metabolic Bone Disease, Second Edition is a comprehensive source dedicated to better understanding this group of conditions that have significant consequences for health in both past and present communities on a global scale. This edition presents an updated introduction to the biology and metabolism of mineralised tissues that are fundamental to understanding the expression of the metabolic bone diseases in skeletal remains. The extensive advances in understanding of these conditions in both bioarchaeological and biomedical work are brought together for the reader. Dedicated chapters focussing on each disease emphasise the integration of up-to-date clinical background with the biological basis of disease progression to give guidance on identification. New chapters covering anaemia and approaches to recognising the co-occurrence of pathological conditions have been included, reflecting recent advances in research. Boxes highlighting significant issues, use of information from sources such as texts and nonhuman primates, and theoretical approaches are included in the text. Each chapter closes with ‘Core Concepts’ that summarise key information. The final chapter reviews current challenges in bioarchaeology and provides directions for future research. This is a must-have resource for users at all career stages interested in integrating information on the metabolic bone diseases into bioarchaeological projects. Covers deficiencies of vitamin C and D, osteoporosis (age-related and secondary), Paget’s disease of bone, anaemia and approaches to disease co-occurrence Contains clear and user-friendly guidance for macroscopic, radiological and microscopic diagnoses Highlights current inquiries and debates in biological anthropology, bioarchaeology, palaeopathology, medical history and clinical/biomedical research Extensive figures, most new or updated, provide invaluable information on biological processes and lesion expression through diagrams and photographs


Forensic Anthropology

Forensic Anthropology
Author: C. Clifford Boyd, Jr.
Publisher: John Wiley & Sons
Total Pages: 372
Release: 2018-03-19
Genre: Medical
ISBN: 1119226384

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Provides comprehensive coverage of everything that students and practitioners need to know about working in the field of forensic anthropology Forensic anthropology has been plagued by questions of scientific validity and rigor despite its acceptance as a section in the American Academy of Forensic Sciences nearly half a century ago. Critics have viewed it as a laboratory-based applied subfield of biological anthropology, and characterised it as emphasising methodology over theory. This book shows that these views are not only antiquated, but inadequate and inaccurate. Forensic Anthropology: Theoretical Framework and Scientific Basis introduces readers to all of the theoretical and scientific foundations of forensic anthropology — beginning with how it was influenced by the early theoretical approaches of Tyler, Morgan, Spencer and Darwin. It instructs on how modern forensic science relies on an interdisciplinary approach — with research being conducted in the fields of archaeology, physics, geology and other disciplines. This modern approach to theory in forensic anthropology is presented through the introduction and discussion of Foundational, Interpretive and Methodological theories. Sections cover: Bias and Objectivity in Forensic Anthropology Theory and Practice; The Theory and Science Behind Biological Profile and Personal Identification; Scientific Foundation for Interpretations of Antemortem, Perimortem, and Postmortem Processes; and Interdisciplinary Influences, Legal Ramifications and Future Directions. Illustrates important aspects of the theory building process and reflects methods for strengthening the scientific framework of forensic anthropology as a discipline Inspired by the “Application of Theory to Forensic Anthropology” symposium presented at the 67th annual meeting of the American Academy of Forensic Sciences Chapters written by experts in the field who were presenters at the symposium Forensic Anthropology: Theoretical Framework and Scientific Basis is ideal for university courses in anthropological science, forensic science, criminal science and forensic archaeology.


Comparative Medicine

Comparative Medicine
Author: Erika Jensen-Jarolim
Publisher: Springer Science & Business Media
Total Pages: 310
Release: 2013-12-09
Genre: Science
ISBN: 3709115590

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This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.


Advances in Osteoimmunology

Advances in Osteoimmunology
Author: Claudine Blin-Wakkach
Publisher: Frontiers Media SA
Total Pages: 355
Release: 2020-01-21
Genre:
ISBN: 2889633241

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MicroRNA in Regenerative Medicine

MicroRNA in Regenerative Medicine
Author: Chandan K. Sen
Publisher: Academic Press
Total Pages: 1134
Release: 2023-05-08
Genre: Science
ISBN: 0128207221

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Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence. Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside Includes short, applied chapters offering focused discussion and practical examples Incorporates multi-color text layout with more than 150 color figures to illustrate important findings