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Organometallic Chemistry in Industry

Organometallic Chemistry in Industry
Author: Thomas J. Colacot
Publisher: John Wiley & Sons
Total Pages: 336
Release: 2020-05-26
Genre: Science
ISBN: 3527345175

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Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.


Organometallics as Catalysts in the Fine Chemical Industry

Organometallics as Catalysts in the Fine Chemical Industry
Author: Matthias Beller
Publisher: Springer
Total Pages: 165
Release: 2012-08-31
Genre: Science
ISBN: 3642328334

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Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.


Organometallics in Process Chemistry

Organometallics in Process Chemistry
Author: Ahmed F. Abdel-Magid
Publisher: Springer Science & Business Media
Total Pages: 316
Release: 2004-06-15
Genre: Science
ISBN: 9783540016038

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The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.


Organometallics for Green Catalysis

Organometallics for Green Catalysis
Author: Pierre H. Dixneuf
Publisher: Springer
Total Pages: 301
Release: 2019-02-25
Genre: Science
ISBN: 3030109550

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This volume presents the latest developments in the use of organometallic catalysis for the formation of bulk chemicals and the production of energy, via green processes including efficient utilization of waste feedstocks from industry. The chemistry of carbon dioxide relating to its hydrogenation into methanol –an eco-friendly energy storage strategy– and its uses as C1 synthon for the formation of important building-blocks for fine chemicals industry are covered. Catalytic hydrogenations of various functional groups and hydrogen transfer reactions including the use of first row metal catalysts are presented as well as the conversion of alcohols to carboxylates via hydrogen transfer with a zero-waste strategy using water. Transformation of renewable or bio-based raw materials is surveyed through alkene metathesis and C–O bond activations and functionalizations. A green aspect for selective formation of C-C, C-O and C-N bonds involves direct regioselective C–H bond activations and functionalizations. These transformations can now be promoted under mild reaction conditions due to the use photoredox catalyts. C–H bond oxidation using visible light leads mainly to the formation of C–O and C–N bonds, whereas cross-coupled C–C bonds can be formed through the radical additions on (hetero) arenes using photoredox assisted mechanism.


Applied Organometallic Chemistry and Catalysis

Applied Organometallic Chemistry and Catalysis
Author: Robin Whyman
Publisher: OUP Oxford
Total Pages: 97
Release: 2001-07-05
Genre: Science
ISBN: 9780198559177

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This Primer has two main objectives: to provide an overview of the influence of organometallic chemistry on homogeneous and heterogenous catalysis and to provide an account of the principle commercial applications of homogeneous catalysis in industry. The book builds on the coverage of organometallic chemistry in two Primers by Bochmann, OCPs 12 and 13.


Organotransition Metal Chemistry

Organotransition Metal Chemistry
Author: Anthony F. Hill
Publisher: Royal Society of Chemistry
Total Pages: 198
Release: 2002
Genre: Education
ISBN: 9780854046225

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What do a pharmaceutical, polymer and solid state chemist have in common? Organometallic chemistry of course, since progress in their diverse fields has at many times relied on this. It is a discipline which stands at the crossroads of so many branches of chemistry, with industrial applications ranging from the gram to megatonne scale. This book aims to introduce undergraduates to the utility of organotransition metal chemistry, a discipline of importance to scientists and technologists in a variety of industry sectors. The main focus will be on the reactivity of organometallic compounds of the transition metals, supported by discussion of structure and bonding and their implications. The aim, on completion of the course, is that a student will be equipped to recognize the key classes of organometallic compounds, their methods of characterization, possible synthetic routes and anticipated reactivity. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.


Organometallic Chemistry

Organometallic Chemistry
Author: Gary O. Spessard
Publisher: Oxford University Press, USA
Total Pages: 0
Release: 2016
Genre: Chemistry, Organic
ISBN: 9780199342679

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Designed with the needs of both undergraduate and graduate students in mind, Organometallic Chemistry, Third Edition, covers the fundamentals of organometallic chemistry by presenting seminal experiments, analyzing real data, and offering the most comprehensive problem sets available. The text opens with careful explanations of the structure and bonding of organometallic compounds, providing a uniquely accessible introduction to the subject for undergraduate students. Later chapters build on this foundation with in-depth coverage of more advanced topics such as organometallic reaction mechanisms, catalysis, carbene complexes, metathesis, applications of organometallic chemistry to organic synthesis, and bioorganometallic chemistry.


Supramolecular Organometallic Chemistry

Supramolecular Organometallic Chemistry
Author: Ionel Haiduc
Publisher: John Wiley & Sons
Total Pages: 484
Release: 2008-11-21
Genre: Science
ISBN: 3527613552

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Supramolecular chemistry has become not only a major field of chemistry, but is also a vivid interface between chemistry, biology, physics, and materials science. Although still a relatively young field, termini such as molecular recognition, host-guest chemistry, or self-assembly are now common knowledge even for chemistry students, and research has already been honored with a Nobel Prize. This first book on supramolecular organometallic chemistry combines two areas in chemistry that are experiencing the fastest developments. It provides a comprehensive review of various organometallic assemblies, arranged according to the types of intermolecular bonding. Details on the synthesis, structures, and properties of these compounds will be a valuable asset to the scientific community. The broad spectrum of assemblies containing main group element, transition metal, or f-element metal and a diverse range of ligands, held together by different bonding interactions make this a fascinating compilation. Illustrated extensively, this book is a very easily accessible, yet wide-ranging source of information.


Fundamentals of Organometallic Catalysis

Fundamentals of Organometallic Catalysis
Author: Dirk Steinborn
Publisher: John Wiley & Sons
Total Pages: 484
Release: 2011-11-30
Genre: Technology & Engineering
ISBN: 3527327177

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Vor allem an Studenten fortgeschrittener Semester und Doktoranden gerichtet ist dieses Lehrbuch der Katalyse mit metallorganischen Verbindungen, das auch biologisch relevanten Reaktionen viel Platz einräumt. Hervorragend zum Selbststudium geeignet - mit zahlreichen Übungsaufgaben, nach Schwierigkeitsgraden geordnet und durch Lösungen ergänzt.


Organometallic Compounds in the Environment

Organometallic Compounds in the Environment
Author: P. J. Craig
Publisher: John Wiley & Sons
Total Pages: 434
Release: 2003-09-12
Genre: Science
ISBN: 0470864885

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A knowledge of the chemical structure and concentration of organometal compounds throughout the ecosystem is important in working out the pathways and mechanisms by which metals distribute themselves throughout the environment. Treating the topic as an integrated subject area, the Second Edition of Organometallic Compounds in the Environment covers all the recent developments in analytical techniques and reports all the new work that has been achieved since the first book. Covers the general importance and characteristics of organometallic species. Includes general developments in analytical techniques. Discusses several minority elements including antimony and selenium. The book addresses the subject in a single, manageable size and each chapter can be used either as a single review or sequentially within the topic area. A useful resource for all researchers and scientists in industry working with organometallic compounds, including, chemists, environmentalists and ecologists.