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| Author | : Dunfang Zhang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 158 |
| Release | : 2023-07-03 |
| Genre | : Medical |
| ISBN | : 2832527884 |
| Author | : Avi-Hai Hovav |
| Publisher | : Frontiers Media SA |
| Total Pages | : 164 |
| Release | : 2021-08-03 |
| Genre | : Medical |
| ISBN | : 2889711358 |
The oral mucosa is a challenging environment from an immunological perspective, containing discrete niches with a unique architecture and function that requires precise adjustment of the immune system. Being the port of entry to the gastrointestinal and respiratory tracts, the oral cavity is also constantly challenged by antigens derived from air and food. Moreover, the oral cavity is the sole tissue of the body harboring a hard surface (i.e. the tooth) that is exposed to the hostile external environment, resulting in the formation of a complex biofilm that has local and systemic effects. To deal with such challenges, the oral immune system aims to prevent the invasion of pathogens/harmful antigens and to tolerate non-pathogenic counterparts in order to maintain homeostasis. In recent years, numerous studies have addressed these fundamental issues, revealing sophisticated mechanisms engaged by the immune system to maintain oral mucosal homeostasis and to combat various immunological insults. Some of these studies have identified novel immunological mechanisms, emphasizing the uniqueness of the oral immune system and the necessity to further investigate its functions.
| Author | : Kenneth Murphy |
| Publisher | : Garland Science |
| Total Pages | : |
| Release | : 2010-06-22 |
| Genre | : Medical |
| ISBN | : 9780815344575 |
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
| Author | : P. Brandtzaeg |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 66 |
| Release | : 2013-09-30 |
| Genre | : Medical |
| ISBN | : 0128086947 |
The intestinal immune system has generated two arms of adaptive anti-inflammatory defense which normally preserve the epithelial barrier: (i) immune exclusion performed by secretory IgA (SIgA) (and SIgM) antibodies to control surface colonization of micro-organisms and dampen penetration of potentially harmful antigens; and (ii) suppressive mechanisms to avoid hypersensitivity to innocuous antigens, particularly food proteins and the commensal microbiota. The latter phenomenon (‘oral tolerance’) largely depends on regulatory T (Treg) cells induced in mesenteric lymph nodes to which mucosal dendritic cells carry exogenous antigens and become conditioned for stimulation of Treg cells. Polymeric Ig receptor (pIgR/SC) knock-out mice that lack SIgA and SIgM show decreased epithelial barrier function and increased uptake of antigens from food and commensal bacteria. They therefore have a hyper-reactive immune system which is counteracted by enhanced intestinal tolerance induction as a homeostatic back-up mechanism.
| Author | : Lesley Ann Bergmeier |
| Publisher | : Springer |
| Total Pages | : 187 |
| Release | : 2018-03-01 |
| Genre | : Medical |
| ISBN | : 3319560654 |
This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owing to the tendency to assume similarity to the gut mucosa. More recently it has become apparent that the oral mucosa is a complex environment and, like the esophageal mucosa, has more in common with vaginal tissue than with the gut. Furthermore, the ability of the oral mucosa to act as an immune inductive site has made it an attractive area of research in terms of desensitization for allergic reactions and possibly autoimmune responses. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level.
| Author | : Takahiro Chino |
| Publisher | : |
| Total Pages | : 180 |
| Release | : 2008 |
| Genre | : |
| ISBN | : |
| Author | : Antonio Nanci |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 432 |
| Release | : 2007-09-26 |
| Genre | : Medical |
| ISBN | : 0323058485 |
Take your understanding to a whole new level with Pageburst digital books on VitalSource! Easy-to-use, interactive features let you make highlights, share notes, run instant topic searches, and so much more. Best of all, with Pageburst, you get flexible online, offline, and mobile access to all your digital books. Understand oral histology and learn to apply your knowledge in the clinical setting with this definitive reference. Updated and enhanced, it provides insight on contemporary research and trends in oral histology, embryology, physiology, oral biology, and postnatal growth and development essential to your success in dentistry! Topics for Consideration boxes present expert perspectives on current trends and encourage additional research. Content outlines provide quick reference to specific topics within chapters. Logical organization enhances your understanding of chapter content and helps you review more effectively. Up-to-date recommended readings direct you to additional sources of relevant information. Concise, user-friendly writing style makes complex concepts easier to grasp. Companion CD includes over 300 multiple choice questions and over 100 labeling exercises that help you assess your comprehension and prepare for Part I of the board exam. Hundreds of full-color illustrations visually acquaint you with the oral structures and microscopic anatomy you'll encounter in dental care. Electronic image collection included on the companion CD is now in full-color, giving you clear, vibrant visual references for convenient study and review.
| Author | : Lesley Ann Bergmeier |
| Publisher | : Frontiers Media SA |
| Total Pages | : 213 |
| Release | : 2022-04-19 |
| Genre | : Medical |
| ISBN | : 2889749460 |
| Author | : Georgios N. Belibasakis |
| Publisher | : Springer Nature |
| Total Pages | : 192 |
| Release | : 2019-11-15 |
| Genre | : Medical |
| ISBN | : 3030285243 |
The first International Conference on Oral Mucosal Immunity and Microbiome (OMIM) aimed to highlight cutting-edge basic and translational research from an oral immunological and microbiological perspective. Oral diseases with a microbial etiology are the most prevalent chronic diseases of humans. Whilst not life-threatening, they can significantly compromise quality of life, are associated with increased risk for certain systemic diseases, and pose heavy financial burdens to national health systems. Hence, periodontal and peri-implant diseases, dental caries, root canal infections and mucosal infections are significant global public health problems. In this book global experts summarize and discuss the latest progress made in oral mucosal immunity and the oral microbiome. Target audience is basic and/or translational researchers with expertise in host immunity and microbiome research, and interest in oral health and disease. This volume provides a much needed quantum leap in the field, by joining forces to address gaps at the oral mucosal immunity-microbiome cross-talk.
| Author | : Phillip Smith |
| Publisher | : Garland Science |
| Total Pages | : 615 |
| Release | : 2020-04-21 |
| Genre | : Medical |
| ISBN | : 1000754499 |
This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.
