Oral Delivery Of Insulin PDF Download
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Author | : T.A. Sonia |
Publisher | : Elsevier |
Total Pages | : 361 |
Release | : 2014-12-11 |
Genre | : Medical |
ISBN | : 1908818689 |
Download Oral Delivery of Insulin Book in PDF, ePub and Kindle
Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field
Author | : Mukur Gupta |
Publisher | : |
Total Pages | : 358 |
Release | : 2004 |
Genre | : Diabetes |
ISBN | : |
Download Design, Development and Evaluation of an Oral Delivery System for Insulin Book in PDF, ePub and Kindle
Author | : Sunandini Chopra |
Publisher | : |
Total Pages | : 177 |
Release | : 2017 |
Genre | : |
ISBN | : |
Download Development of Nanoparticles for Oral Delivery of Insulin Book in PDF, ePub and Kindle
Parenteral administration remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Although oral delivery of many small molecule drugs is routine, oral delivery of protein drugs - e.g. insulin presents several challenges including oral bioavailability of the protein therapeutic because of degradation in the stomach, inactivation and digestion of the therapeutics by the proteolytic enzymes in the luminal cavity, and poor permeability of drugs across the intestinal epithelium. Polymeric nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have the potential to address challenges associated with effective oral delivery of insulin. NPs can protect the protein therapeutic from degradation in the GI tract as well as allow targeted transport across the epithelial lining. An efficient NP based oral insulin delivery solution that can enable targeted transport of insulin across the GI tract must have (1) high insulin loading, (2) sub-100 nm size, (3) ability to release insulin before opsonization by macrophages and (4) the ability to be surface-functionalized with ligands that facilitate transport across the epithelium. This work presents a detailed study on mechanistic understanding of polymeric insulin NP formation with a focus on the effect of synthesis parameters on insulin loading and NP size. We report how buffer conditions, ionic chelation, and NP preparation methods influence insulin loading in poly (lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) NPs. We report a 10-fold increase in insulin loading with the use of chelating zinc ions and by the optimization of the pH during nanoprecipitation. Next, we report the development of novel insulin Eudragit-PLGA-PEG blended NPs (Ins-Eud-NPs) with high insulin loading (13.1%) and sub-100 nm size. These NPs enable rapid release of insulin when triggered by a change in pH that occurs when the NPs cross the duodenal epithelium and go from acidic to neutral pH. The NPs are formed by successfully blending Eudragit S100, a commercially available polymer which dissolves at pH greater than 7 with a non-pH responsive polymer, PLGA-PEG. To enable effective transport of these NPs across the epithelial lining, NPs were designed to use the FcRn transport pathway that mediates IgG antibody transport across epithelial barriers. We report the successful chemical conjugation of the Fc fragment on the surface of Ins-Eud- NPs by overcoming the presence of non-ideal conjugation parameters owing to the pH restrictions of the system. This dissertation provides mechanistic insights and helps to understand fundamental concepts about polymeric NP formation and protein encapsulation. The modular NP system developed in this work can be extended to other protein drug delivery systems that are subject to limited drug loading and restricted transport across epithelial barriers.
Author | : Zakieh Al Kurdi |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Subcutaneous and Oral Delivery of Insulin Book in PDF, ePub and Kindle
Author | : Amit Kumar Nayak |
Publisher | : Springer Nature |
Total Pages | : 390 |
Release | : 2020-07-11 |
Genre | : Technology & Engineering |
ISBN | : 3030469239 |
Download Advanced Biopolymeric Systems for Drug Delivery Book in PDF, ePub and Kindle
This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.
Author | : Emmanuel Opara |
Publisher | : CRC Press |
Total Pages | : 369 |
Release | : 2020-02-28 |
Genre | : Medical |
ISBN | : 0429584652 |
Download Controlled Drug Delivery Systems Book in PDF, ePub and Kindle
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Author | : Etienne Cabane |
Publisher | : |
Total Pages | : 324 |
Release | : 2007 |
Genre | : |
ISBN | : |
Download Nanoparticle Mediated Oral Delivery of Insulin Book in PDF, ePub and Kindle
Author | : Philip Cryer |
Publisher | : American Diabetes Association |
Total Pages | : 194 |
Release | : 2016-07-12 |
Genre | : Medical |
ISBN | : 1580406491 |
Download Hypoglycemia in Diabetes Book in PDF, ePub and Kindle
Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.
Author | : Ali Demir Sezer |
Publisher | : IntechOpen |
Total Pages | : 514 |
Release | : 2012-10-31 |
Genre | : Medical |
ISBN | : 9789535108108 |
Download Recent Advances in Novel Drug Carrier Systems Book in PDF, ePub and Kindle
This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Author | : Majid Tabbakhian |
Publisher | : |
Total Pages | : 0 |
Release | : 1998 |
Genre | : Insulin |
ISBN | : |
Download Oral Delivery of Insulin by Polymer-coated Liposomes Book in PDF, ePub and Kindle