Oral Colon Specific Drug Delivery PDF Download
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Author | : David R. Friend |
Publisher | : CRC Press |
Total Pages | : 292 |
Release | : 1992-07-27 |
Genre | : Medical |
ISBN | : 9780849366888 |
Download Oral Colon-Specific Drug Delivery Book in PDF, ePub and Kindle
Oral Colon-Specific Drug Delivery covers approaches used to deliver a variety of drugs to the colon. Anatomy and physiology of the gastrointestinal tract as it affects colonic drug delivery and pharmacokinetics are reviewed, as well as drug absorption from the colon. The book presents valuable information on a variety of topics, including oral peptide/protein delivery, dextran-based delivery systems, glycoside/glycosidase-based delivery, azo-bond prodrugs, hydroxypropyl methacrylamide copolymers for colonic delivery, and matrices for colonic drug delivery. Special emphasis is placed on delivery systems, especially biochemical approaches to delivery, such as the use of degradable polymers and both low and high molecular weight prodrugs. Oral Colon-Specific Drug Delivery will provide a valuable reference resource for gastroenterologists, pharmaceutical scientists, and other researchers working with drug delivery to the colon.
Author | : Hamidreza Ghandehari |
Publisher | : |
Total Pages | : 374 |
Release | : 1996 |
Genre | : Drugs |
ISBN | : |
Download Oral Colon-specific Drug Delivery Book in PDF, ePub and Kindle
Author | : Sougata Jana |
Publisher | : Springer Nature |
Total Pages | : 489 |
Release | : 2020-03-05 |
Genre | : Medical |
ISBN | : 9811502633 |
Download Functional Chitosan Book in PDF, ePub and Kindle
Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.
Author | : Reinout Cornelus Andreas Schellekens |
Publisher | : |
Total Pages | : 218 |
Release | : 2011 |
Genre | : |
ISBN | : 9789036749367 |
Download Translational Research Into Oral Colon-specific Drug Delivery: from Laboratory to Clinic Book in PDF, ePub and Kindle
Author | : Mukesh R. Patel |
Publisher | : LAP Lambert Academic Publishing |
Total Pages | : 96 |
Release | : 2012-06 |
Genre | : |
ISBN | : 9783847309765 |
Download Design and Development of Colon Targeted Drug Delivery System Book in PDF, ePub and Kindle
The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn s diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co
Author | : Hong Wen |
Publisher | : John Wiley & Sons |
Total Pages | : 571 |
Release | : 2011-01-14 |
Genre | : Science |
ISBN | : 1118060326 |
Download Oral Controlled Release Formulation Design and Drug Delivery Book in PDF, ePub and Kindle
This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.
Author | : Pirjo Nykänen |
Publisher | : |
Total Pages | : 49 |
Release | : 2003 |
Genre | : |
ISBN | : 9789521010453 |
Download Development of Multiple-unit Oral Formulations for Colon-specific Drug Delivery Using Enteric Polymers and Organic Acids as Excipients Book in PDF, ePub and Kindle
Author | : Clive G. Wilson |
Publisher | : Springer Science & Business Media |
Total Pages | : 415 |
Release | : 2011-09-22 |
Genre | : Medical |
ISBN | : 1461410045 |
Download Controlled Release in Oral Drug Delivery Book in PDF, ePub and Kindle
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Author | : Nirav Patel |
Publisher | : LAP Lambert Academic Publishing |
Total Pages | : 288 |
Release | : 2011 |
Genre | : Colon (Anatomy) |
ISBN | : 9783844394825 |
Download Design and Evaluation of Colon Specific Drug Delivery System Book in PDF, ePub and Kindle
Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn s diseases, ulcerative colitis, irritable bowl syndrome but also for the potential it holds for the systemic delivery of proteins and therapeutic peptides. Targeted drug delivery to the colon would therefore, ensure direct treatment at the disease site and, consequently, lower dosing and reducing systemic side effects. The most critical challenge in such drug delivery approach is to preserve the formulation during its passage through the stomach and about first six meters of small intestine. In the present investigations, two drugs mesalamine and budesonide was selected for ulcerative colitis in colon. An attempt was made to prepare formulations which could not release the drug into stomach for up to 2 h. which is residence time for it, also it could not release the drug into small intestine up to 3 h. which is residence time for it and could release the drug up to 24 h to 3 days which is residence time for colon. These attempts formulate the colon targeted controlled release dosage form for ulcerative colitis.
Author | : Chirag Patel |
Publisher | : LAP Lambert Academic Publishing |
Total Pages | : 92 |
Release | : 2013 |
Genre | : |
ISBN | : 9783659275692 |
Download Colon Specific Drug Delivery System Book in PDF, ePub and Kindle
The present study has been a satisfactory attempt to formulate microparticulate system for colon targeted delivery of albendazole using natural polysaccharides sodium alginate and chitosan. Targeted drug delivery to the colon, by means of combination of one or more controlled release mechanisms, hardly releases drug in the upper part of the GIT but releases in the colon following oral administration. Specifically delivering drug to the colon, a lot of benefits would be acquired in terms of improving safety and reducing toxicity when treating local or systemic chronic diseases. We sincerely hope that this book will helpful to student as well as industry and academic professionals involved in pharmaceutical and other related science.