Opsin Free Optogenetics PDF Download
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| Author | : Yubin Zhou |
| Publisher | : CRC Press |
| Total Pages | : 221 |
| Release | : 2022-12-14 |
| Genre | : Medical |
| ISBN | : 1000787567 |
Download Opsin-free Optogenetics Book in PDF, ePub and Kindle
Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash of light. Manipulating the temporal and spatial profile of light enabled precise control of membrane potentials. This feature has inspired non-opsin-based optogenetics, which not only inherits the precise spatiotemporal resolution but also expands the targets into a diverse pool of biomolecules such as membrane receptors, ion channels, kinases, GTPases, and transcription factors. This book is unique because it emphasizes the design and applications of opsin-free optogenetic tools. Key Features Describes new developments in non-opsin-based optogenetic tools Introduces cutting-edge methods for precise modulation of cell signaling Highlights applications of optogenetic regulation of cellular functions Covers contributions from an international team of leading experts Related Titles Lim, W. & B. Mayer – Cell Signaling (ISBN 9780815342441) Ayyanathan, K., ed. – Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 9781774630839) Zhang , J. et al., eds. – Optical Probes in Biology (ISBN 9781138199934)
| Author | : Hiromu Yawo |
| Publisher | : Springer Nature |
| Total Pages | : 648 |
| Release | : 2021-01-05 |
| Genre | : Medical |
| ISBN | : 9811587639 |
Download Optogenetics Book in PDF, ePub and Kindle
This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.
| Author | : Yutong Zhao |
| Publisher | : CRC Press |
| Total Pages | : 436 |
| Release | : 2024-02-20 |
| Genre | : Medical |
| ISBN | : 1003833284 |
Download Lung Biology and Pathophysiology Book in PDF, ePub and Kindle
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics. Key Features Highlights the role the lungs play as an interface between the body and the environment Describes the underlying mechanism of lung diseases Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function Includes contributions from leading researchers Chapters 8 and 13 of this book are available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
| Author | : Jacopo Lamanna |
| Publisher | : Frontiers Media SA |
| Total Pages | : 117 |
| Release | : 2023-11-10 |
| Genre | : Science |
| ISBN | : 2832536379 |
Download Recent Advances in Measuring and Controlling Synaptic Communication Book in PDF, ePub and Kindle
Synapses represent a unique neuronal compartment specialized in communication. The morpho-functional investigation of the synapse has always been hindered by its tiny size and high density of molecular elements, but specific technological and methodological advances helped us to reduce these limitations. As the matter of fact, in recent years, we have witnessed the continuous development of new methods allowing measuring and controlling synaptic activation both in vitro and in vivo. These include new genetically encoded sensors of synaptic exo-endocytosis, but also engineered synaptic proteins able to inhibit the release of neurotransmitters. Furthermore, new promising tools allow changing the functional properties of synapses in a plasticity-like manner. All these methodological advances are likely to generate unprecedented knowledge about the dynamics of synaptic transmission and plasticity at several levels of the nervous system. Nevertheless, in most cases, the implementation of these new methods remains technically demanding, likely due to the high complexity of their operating principle. Hence, it would be worth refining and potentiating these tools in order to extend the range of experimental settings for their application.
| Author | : Qingjun Liu |
| Publisher | : Artech House |
| Total Pages | : 291 |
| Release | : 2009-10 |
| Genre | : Medical |
| ISBN | : 1596934409 |
Download Cell-based Biosensors Book in PDF, ePub and Kindle
Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
| Author | : Elliot Krames |
| Publisher | : Academic Press |
| Total Pages | : 1828 |
| Release | : 2018-01-05 |
| Genre | : Science |
| ISBN | : 0128093021 |
Download Neuromodulation Book in PDF, ePub and Kindle
Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine. Provides a comprehensive reference that covers all aspects of the growing field of neuromodulation Written by international, leading authorities in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering Includes new chapters on optogenetics, bioelectronics medicine and brain computer interfacing
| Author | : Society for Neuroscience |
| Publisher | : Coe-Truman Technologies |
| Total Pages | : |
| Release | : 2011-02-18 |
| Genre | : Medical |
| ISBN | : 161330000X |
Download SfN 2010 Daily Books Book in PDF, ePub and Kindle
| Author | : Krishnarao Appasani |
| Publisher | : Cambridge University Press |
| Total Pages | : 537 |
| Release | : 2017-04-27 |
| Genre | : Medical |
| ISBN | : 1108146090 |
Download Optogenetics Book in PDF, ePub and Kindle
Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson's disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.
| Author | : Jeffrey M. Liebman |
| Publisher | : |
| Total Pages | : 456 |
| Release | : 1989 |
| Genre | : Medical |
| ISBN | : |
Download The Neuropharmacological Basis of Reward Book in PDF, ePub and Kindle
This volume reviews recent major advances in reinforcement and behaviour. The contributors, all prominent physiological psychologists and behavioural pharmacologists, have extensively analysed current research on drugs, brain neurotransmitters, and reinforcement in animals. The book documents convergent evidence that implicates the nucleus accumbens and its dopaminergic afferents in reward. Controversial themes include the identity of the neurons mediating intracranial self-stimulation, and whether or not non-dopaminergic neurons can independently mediatereinforcement. Exciting new technical advances, such as conditioned place preferences, intracranial microinjection, and self-administration of drugs, as well as advanced new techniques for measuring the specificity of drug effects on reinforcement, are thoroughly explained and future research directionsoutlined.
| Author | : Zhenxi Zhang |
| Publisher | : John Wiley & Sons |
| Total Pages | : 309 |
| Release | : 2023-02-06 |
| Genre | : Science |
| ISBN | : 3527823549 |
Download Biomedical Photonic Technologies Book in PDF, ePub and Kindle
Biomedical Photonic Technologies A state-of-the-art examination of biomedical photonic research, technologies, and applications In Biomedical Photonic Technologies, a team of distinguished researchers delivers a methodical inquiry and evaluation of the latest developments in the field of biomedical photonics, with a focus on novel technologies, including optical microscopy, optical coherence tomography, fluorescence imaging-guided surgery, photodynamic therapy dosimetry, and optical theranostic technologies. Each discussion of individual technologies includes examples of their contemporary application in areas like cancer therapy and drug delivery. Readers will discover the major research advancements in biomedical photonics from the last 20 years, ascertaining the basic principles of formation, development, and derivation of biomedical photonics phenomena at a variety of scales. Readers will also find: A thorough introduction to advanced wide-field fluorescent microscopy for biomedicine Comprehensive explorations of fluorescence resonance energy transfer and optical coherence tomography for structural and functional imaging Practical exploration of coherent Raman scattering microscopy and biomedical applications, as well as fluorescence image-guided surgery Complete analyses of enhanced photodynamic therapy, optogenetics, and optical theranostics employing gold nanoparticles Perfect for biophysicists and applied physicists, Biomedical Photonic Technologies will also benefit bioengineers and biotechnologists in academia and in industry.
