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Author | : Patricia Kahn |
Publisher | : Springer Science & Business Media |
Total Pages | : 384 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642733255 |
Download Oncogenes and Growth Control Book in PDF, ePub and Kindle
How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.
Author | : Harvey Bialy |
Publisher | : North Atlantic Books |
Total Pages | : 332 |
Release | : 2004 |
Genre | : Biography & Autobiography |
ISBN | : 9781556435317 |
Download Oncogenes, Aneuploidy, and AIDS Book in PDF, ePub and Kindle
According to author Harvey Bialy, the work of molecular biologist Peter Duesberg has been grossly distorted by the media and scientific establishments. Until recently, the scientific community--and most notably, those from the National Institute for Health--have been unwilling to look at his provocative theories of different causes for cancer and HIV/AIDS. Inspired by UC Berkeley's rare creation of an archive for Duesberg's papers, this book explores Duesberg's early groundbreaking work with viruses and oncogenes, his contentious fights with other scientists, and the profound influence of his life's work.
Author | : Robin Hesketh |
Publisher | : Elsevier |
Total Pages | : 608 |
Release | : 1997-07-11 |
Genre | : Medical |
ISBN | : 9780080538006 |
Download The Oncogene and Tumour Suppressor Gene Factsbook Book in PDF, ePub and Kindle
The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. Includes much new data on this fast-moving field, including newly discovered oncogenes Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes Contains more than 2000 terms for reference and further research Revised to included signaling pathways, apoptosis, and metastasis
Author | : James DeGregori |
Publisher | : Harvard University Press |
Total Pages | : 289 |
Release | : 2018-03-09 |
Genre | : Science |
ISBN | : 0674545397 |
Download Adaptive Oncogenesis Book in PDF, ePub and Kindle
Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cellsÕ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a speciesÕ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregoriÕs perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissuesÕ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.
Author | : Geoffrey M. Cooper |
Publisher | : Jones & Bartlett Learning |
Total Pages | : 404 |
Release | : 1995 |
Genre | : Antioncogenes |
ISBN | : 9780867209372 |
Download Oncogenes Book in PDF, ePub and Kindle
The second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and scientists by examining the current state of oncogene study and where future research may lead.
Author | : Carmen Avendaño |
Publisher | : Elsevier |
Total Pages | : 767 |
Release | : 2015-06-11 |
Genre | : Science |
ISBN | : 0444626670 |
Download Medicinal Chemistry of Anticancer Drugs Book in PDF, ePub and Kindle
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature
Author | : Luciano Torres |
Publisher | : Nova Science Publishers |
Total Pages | : 0 |
Release | : 2013 |
Genre | : Oncogenes |
ISBN | : 9781626188686 |
Download Oncogenes Book in PDF, ePub and Kindle
An oncogene is a modified gene, or a series of nucleotides that encode a protein, and direct the cell to the development of a neoplastic phenotype. Usually, oncogenes are involved in tumour development and increase the possibility that the development of a cell directs towards cancer. In this book, the authors present current research in the study of the classification, mechanisms of activation and role in cancer development of oncogenes. Topics include the role of oncogenes in gynaecological pathology; oncomirs as the next frontier of oncogenes affecting cancer aetiology and tumour progression; the role of the epidermal growth factor receptor as a therapeutic target in glioblastoma and other malignancies; and tumour suppressers involved in DNA repair and carcinoprevention.
Author | : Stuart A. Aaronson |
Publisher | : VSP |
Total Pages | : 344 |
Release | : 1987-12 |
Genre | : Science |
ISBN | : 9789067641012 |
Download Oncogenes and Cancer Book in PDF, ePub and Kindle
Discoveries that a small subset of cellular genes --- proto-oncogenes --- are frequent targets of carinogenic insults or chance that convert them to oncogenes have opened new areas of approach to understanding and eventually controlling the events leading to cancer. New technology has made it possible not only to identify genes involved in the etiology of cancer, but to dissect their molecular composition. This symposium brought together scientists from areas of carcinogenesis and molecular biology to review the state-of-the-art in this field. The papers presented in this proceedings volume can be grouped into four broad areas: the mechanisms of onc gene activation and associations of onc genes with tumours, the mechanisms of onc gene action, the physiology of proto-onc genes, and the discovery and characterization of new onc genes.
Author | : Enrique Pimentel |
Publisher | : CRC Press |
Total Pages | : 274 |
Release | : 1987-06-30 |
Genre | : Medical |
ISBN | : 9780849353468 |
Download Hormones Growth Factors & Oncogenes Book in PDF, ePub and Kindle
This text examines the hormones and peptide growth factors involved in the regulation of metabolism, growth and differentiation in metazoan organisms and proto-oncogene expression. Investigates protein products of some proto-oncogenes for involvement in the transductional and post-transductional and mechanisms of hormones and peptide growth factors.
Author | : Eric Wong |
Publisher | : Axolotl Academic Publishing |
Total Pages | : 283 |
Release | : 2009 |
Genre | : Biology |
ISBN | : 0985226110 |
Download Cells: Molecules and Mechanisms Book in PDF, ePub and Kindle
"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.