On Forms And Functions PDF Download

Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules. Contents:The Legacy of G N Ramachandran and the Development of Structural Biology in India (M Vijayan)The Open-Ended Intellectual Legacy of GNR (George Rose)The Ramachandran Plot and Protein Structure Validation (Roman A Laskowski, Nicholas Furnham and Janet M Thornton)Analysis of Dihedral Angle Variability in Related Protein Structures (Shekhar C Mande, Ashwani Kumar and Payel Ghosh)Multiprotein Assemblies: Modulating Cell Activity Through Targeting Protein-Protein Interfaces (Alicia P Higueruelo, Harry Jubb and Tom L Blundell)Computational Approaches for Understanding the Recognition Mechanism of Protein Complexes (M Michael Gromiha)Cold-Shock Domains — Versatile Molecular Modules for Single-Stranded RNA Binding and Remodeling (Florian Mayr and Udo Heinemann)Protein Disulfide Analysis and Design (Siddharth Patel, S Indu, C Ramakrishnan and Raghavan Varadarajan)Controlling Conformational Dynamics to Modulate Protein Function (Shahir S Rizk, Marcin Paduch and Anthony A Kossiakoff)Structural Bioinformatics Approaches for Deciphering Biosynthetic Code of Secondary Metabolites (Shradha Khater and Debasisa Mohanty)The Inherent Structure Landscape of Met–Enkephalin Determined by the MOLS Technique (N Balaji, L Ramya and N Gautham)and other papers Readership: Practicing researchers in academia and industry. Keywords:Three-Dimensional Structure;Protein Structures;Biopolymer Conformation;G N Ramachandran;Ramachandran Map Phi-Psi Plot;Nuclei Acid Structures;Macromolecular Interactions;Biomolecular Assemblies;Simulations of Biological Molecular StructuresKey Features:Authors are eminent scientists with well-cited research in structural and computational biologyThe book includes articles covering results obtained using the latest structural biology techniquesThe book covers important areas in the fields of protein folding, association, function and design