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Lipoproteins and Atherosclerosis

Lipoproteins and Atherosclerosis
Author: Claude L. Malmendier
Publisher: Springer Science & Business Media
Total Pages: 248
Release: 2012-12-06
Genre: Science
ISBN: 146841268X

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Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.


Lipoprotein Subfractions Omega-3 Fatty Acids

Lipoprotein Subfractions Omega-3 Fatty Acids
Author: H.U. Klör
Publisher: Springer Science & Business Media
Total Pages: 211
Release: 2012-12-06
Genre: Medical
ISBN: 3642834477

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On November 6 and 7, 1987, lipid and lipoprotein researchers from all over Europe convened in Munich on the occasion of the second European Workshop on Lipid Metabolism (EWLM). This informal gathering was devoted to two main topics, and recent research results were presented and discussed during a poster session. Recent developments in the physiology and pathophysiology of lipoprotein sub fractions were discussed on the first day of the meeting. In recent years, new analytical tools have been created for analyzing lipoprotein subfractions, particularly the apolipoprotein component. With the, introduction of immunological and elec trophoretic methods it has become clear that the heterogeneity of the plasma lipopro tein system is even greater than had been assumed only a decade or so ago. Despite this, it is apparent from the contributions to this volume that new methods for differentiating lipoprotein subfractions will increase our understanding of lipoprotein metabolism, especially of the triglyceride-rich lipoprotein particles and the high density lipoproteins. The complex functions of the various plasma apolipoproteins and their association with the lipoprotein lipid in single or complex lipoprotein particles give rise to a complex and dynamic metabolic system that changes constantly during the day. While it has for some time been possible to delineate fairly accurately the atherogenic potential of low-density lipoproteins, which are comparatively simple lipoprotein particles, the new methods of lipoprotein subfraction analysis will be needed to select and differentiate amongst the potentially atherogenic triglyceride rich particles, especially the chylomicron and very low density lipoprotein remnants.


Hormones, Lipoproteins and Atherosclerosis

Hormones, Lipoproteins and Atherosclerosis
Author: M. Palkovič
Publisher: Elsevier
Total Pages: 557
Release: 2013-10-22
Genre: Medical
ISBN: 1483153835

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Hormones, Lipoproteins and Atherosclerosis, Volume 35, emerged from the international symposium on ""Hormones, Lipoproteins and Atherosclerosis"" held in Bratislava, Czechoslovakia. The symposium was devoted to the problems of hormonal effects on lipoprotein metabolism and atherosclerosis, and was also concerned with problems of composition, structure, synthesis, and degradation of liporoteins, as well as with genetical and clinical aspects. The participants of the symposium have contributed to this volume not only by presenting new data but also new ideas and stimulating new trends in the research and therapy of metabolic derangements of lipoproteins and the resulting pathological conditions. The 51 contributions are organized into five parts. Part I includes papers on the metabolism of lipoproteins. Part II presents studies on hormones and lipoproteins. Part III is devoted to atherosclerosis and lipoproteins. Part IV takes up the clinical aspects of hyperlipoproteinemias. Part V on methods contains two studies—the first on the isolation of human plasma high density lipoproteins; the second on the separation of subfractions of the serum triacylglycerols.


A Balanced Omega-6/Omega-3 Fatty Acid Ratio, Cholesterol and Coronary Heart Disease

A Balanced Omega-6/Omega-3 Fatty Acid Ratio, Cholesterol and Coronary Heart Disease
Author: A.P. Simopoulos
Publisher: Karger Medical and Scientific Publishers
Total Pages: 141
Release: 2009-08-12
Genre: Medical
ISBN: 3805592256

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For more than half a century, the relationship between dietary factors and coronary heart disease (CHD) has been a major focus of health research. Contrary to the established view, current data suggest that dietary cholesterol is not a primary factor of or causes heart disease - with the possible exception of the genetic forms of familial hypercholesterolemias. For instance, recent clinical trials evaluating the effect of cholesterol-lowering drugs on the development of chronic heart failure, diabetes and stroke have yielded disappointing results. On the other hand, an unbalanced omega-6/omega-3 fatty acid ratio and a cholesterol intake not consistent with the amount during evolution seem to be causal factors in the development of CHD. A panel of international experts in genetics, nutrition, fatty acid, cholesterol, metabolism and coronary heart disease has contributed to this publication, summarizing and critically discussing for the first time the importance of evolutionary aspects of diet, the omega-6/omega-3 fatty acid ratio and cholesterol intake relative to health and CHD. They also propose measuring blood fatty acids in the population in order to define the risk of CHD and other chronic diseases. This book will be of interest to physicians (cardiologists, gerontologists, and pediatricians), nutritionists, dieticians, health care providers, scientists in industry and government and policy makers.


Lipoproteins

Lipoproteins
Author: Gerhard Kostner
Publisher: BoD – Books on Demand
Total Pages: 166
Release: 2015-10-07
Genre: Science
ISBN: 9535121782

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In mammalian blood plasma there exist some 6 major lipoprotein classes. Under physiological conditions lipoproteins are certainly beneficial as they transport nutrients and steroids to numerous organs for further metabolism. On the other hand, under pathophysiological conditions most lipoprotein classes promote atherogenesis except of HDL that are considered to be anti-atherogenic. Lipoprotein research is a wide field comprising basic science, analytical methods and clinical investigations. Thus this issue does not raise the claim to give a comprehensive picture of the current knowledge, but rather focuses on specific questions related to animal models in lipoprotein research as well as features of the most atherogenic lipoprotein, Lp(a).


Latest Findings Of Omega-3 Long Chain Polyunsaturated Fatty Acids: From Molecular Mechanisms To New Applications In Health And Diseases

Latest Findings Of Omega-3 Long Chain Polyunsaturated Fatty Acids: From Molecular Mechanisms To New Applications In Health And Diseases
Author: Maricela Rodriguez Cruz
Publisher: Bentham Science Publishers
Total Pages: 103
Release: 2011
Genre: Science
ISBN: 1608051773

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This E-book covers the main aspects about the benefits of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) to human health. The knowledge of physiological effects of LC-PUFAs at different levels is constantly expanding. Topics covered over 10 chapters thoroughly detail the role of omega-3 LCPUFAs in nutrition (gene regulation) and disease (clinical applications); information about food sources and recent intake recommendations is also explained. This book also discusses current data concerning the role of LC-PUFAs during pregnancy and lactation, in cognitive function, immune response.


Lipidology, An Issue of Cardiology Clinics, E-Book

Lipidology, An Issue of Cardiology Clinics, E-Book
Author: Stephen J. Nicholls
Publisher: Elsevier Health Sciences
Total Pages: 237
Release: 2018-04-11
Genre: Medical
ISBN: 0323583490

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This issue of Cardiology Clinics, edited by Dr. Stephen Nicholls, focuses on Lipidology. Topics include, but are not limited to: Impact of lipoproteins on atherobiology; Lessons from genomic studies; Lipids and lipoproteins in risk prediction; Optimizing statins and ezetimibe in guideline focused management; Statin intolerance; Lipid lowering agents and diabetes risk; PCSK9 inhibitors; Bempedoic Acid; Triglyceride rich lipoproteins; Omega 3 Fatty Acids; Lipoprotein; CETP inhibitors; HDL infusions; and Targeting HDL functionality.


Diet and Health

Diet and Health
Author: National Research Council
Publisher: National Academies Press
Total Pages: 765
Release: 1989-01-01
Genre: Medical
ISBN: 0309039940

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Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.