Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 495 Ros Reactive Oxygen Species Assay For Photoreactivity PDF Download
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2019-06-18 |
Genre | : |
ISBN | : 9264567119 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 495: Ros (Reactive Oxygen Species) Assay for Photoreactivity Book in PDF, ePub and Kindle
Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic reactions when activated by light at otherwise non-toxic doses. Phototoxicity can be categorized as photoirritation, photoallergy, and photogenotoxicity. The purpose of this test is to measure the phototoxicity of a chemical. The main event in any phototoxic reaction is the absorption of photons of a wavelength that induces the excitation of the chromophore. Excitation energy is often transferred to oxygen molecules, followed by the generation of ROS (reactive Oxygen Species). Measurements are performed using a spectrometer. The determination of the ROS generation from irradiated chemicals with simulated sunlight is indicative of phototoxic potential.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264353089 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method Book in PDF, ePub and Kindle
Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2004-11-23 |
Genre | : |
ISBN | : 9264071164 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 432: In Vitro 3T3 NRU Phototoxicity Test Book in PDF, ePub and Kindle
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 63 |
Release | : 2015-02-05 |
Genre | : |
ISBN | : 9264229701 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins Book in PDF, ePub and Kindle
This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2009-09-08 |
Genre | : |
ISBN | : 9264070605 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 8 |
Release | : 2004-11-23 |
Genre | : |
ISBN | : 9264071067 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method Book in PDF, ePub and Kindle
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 17 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264185402 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro assay that may be used for identifying water soluble ocular corrosives and severe irritants as defined by the UN Globally Harmonized System of Classification and Labelling, Category 1. The assay is performed ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 14 |
Release | : 2002-02-08 |
Genre | : |
ISBN | : 926407094X |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure Book in PDF, ePub and Kindle
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 13 |
Release | : 2017-10-09 |
Genre | : |
ISBN | : 9264070583 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 12 |
Release | : 1992-07-17 |
Genre | : |
ISBN | : 9264070664 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 406: Skin Sensitisation Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...