Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 456 H295r Steroidogenesis Assay PDF Download
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 27 |
Release | : 2011-07-28 |
Genre | : |
ISBN | : 9264122648 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 456: H295R Steroidogenesis Assay Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 74 |
Release | : 2021-06-17 |
Genre | : |
ISBN | : 9264265295 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists Book in PDF, ePub and Kindle
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 60 |
Release | : 2024-06-25 |
Genre | : |
ISBN | : 9264242627 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity Book in PDF, ePub and Kindle
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology for human recombinant in vitro assays to detect substances with estrogen receptor binding affinity (hrER binding assays).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 26 |
Release | : 2012-10-02 |
Genre | : |
ISBN | : 9264185399 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 15 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264242430 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage Book in PDF, ePub and Kindle
This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2009-09-08 |
Genre | : |
ISBN | : 9264070605 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 14 |
Release | : 2002-02-08 |
Genre | : |
ISBN | : 9264071008 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method Book in PDF, ePub and Kindle
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 84 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264264361 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals Book in PDF, ePub and Kindle
This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 44 |
Release | : 2022-06-30 |
Genre | : |
ISBN | : 9264910557 |
Download OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 251: Rapid Androgen Disruption Activity Reporter (RADAR) assay Book in PDF, ePub and Kindle
The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 14 |
Release | : 2002-02-08 |
Genre | : |
ISBN | : 926407094X |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure Book in PDF, ePub and Kindle
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...