Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 444a In Vitro Immunotoxicity Il 2 Luc Assay PDF Download
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| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 28 |
| Release | : 2023-07-04 |
| Genre | : |
| ISBN | : 926493474X |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 444A: In Vitro Immunotoxicity IL-2 Luc Assay Book in PDF, ePub and Kindle
This Test Guideline (TG) describes the IL-2 Luc Assay test method to evaluate the potential immunotoxic effects of chemicals on T lymphoblastic cell line. This cell line allows quantitative measurement of luciferase gene induction by detecting luminescence from well-established light producing luciferase substrates as indicators of the activity of IL-2, IFN-γ and GAPDH in cells following exposure to immunotoxic chemicals.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 20 |
| Release | : 2004-11-23 |
| Genre | : |
| ISBN | : 9264071164 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 432: In Vitro 3T3 NRU Phototoxicity Test Book in PDF, ePub and Kindle
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 67 |
| Release | : 2018-06-27 |
| Genre | : |
| ISBN | : 9264229825 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation Book in PDF, ePub and Kindle
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 15 |
| Release | : 2023-07-04 |
| Genre | : |
| ISBN | : 9264242430 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage Book in PDF, ePub and Kindle
This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 74 |
| Release | : 2021-06-17 |
| Genre | : |
| ISBN | : 9264265295 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists Book in PDF, ePub and Kindle
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 28 |
| Release | : 2021-06-17 |
| Genre | : |
| ISBN | : 9264242848 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 8 |
| Release | : 2004-11-23 |
| Genre | : |
| ISBN | : 9264071083 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method Book in PDF, ePub and Kindle
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 28 |
| Release | : 2023-07-04 |
| Genre | : |
| ISBN | : 9264353089 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method Book in PDF, ePub and Kindle
Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 14 |
| Release | : 2002-02-08 |
| Genre | : |
| ISBN | : 926407094X |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure Book in PDF, ePub and Kindle
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 8 |
| Release | : 2004-11-23 |
| Genre | : |
| ISBN | : 9264071067 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method Book in PDF, ePub and Kindle
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
