Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 420 Acute Oral Toxicity Fixed Dose Procedure PDF Download
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 14 |
Release | : 2002-02-08 |
Genre | : |
ISBN | : 926407094X |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure Book in PDF, ePub and Kindle
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Author | : Organisation for Economic Co-operation and Development |
Publisher | : |
Total Pages | : 14 |
Release | : 2002 |
Genre | : |
ISBN | : |
Download Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure Book in PDF, ePub and Kindle
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a single sex (normally females) are dosed in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg (exceptionally 5000 mg/kg). The initial dose level is selected on the basis of a sighting study as the dose expected to produce some signs of toxicity without causing severe toxic effects or mortality. Further groups of animals may be dosed at higher or lower fixed doses, depending on the presence or absence of signs of toxicity or mortality. This procedure continues until the dose causing evident toxicity or death is identified, or when no effects are seen at the highest dose or when deaths occur at the lowest dose. The test substance is administered in a single dose by gavage using a stomach tube or a suitable intubation canula. Animals should be fasted prior to dosing. A total of five animals of one sex will normally be used for each dose level investigated. The results of this study include: measurements (weighing at least weekly) and daily detailed observations, as well as gross necropsy. The method provides information on the hazardous properties and allows the substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 14 |
Release | : 2002-02-08 |
Genre | : |
ISBN | : 9264071008 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method Book in PDF, ePub and Kindle
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
Author | : Organisation for Economic Co-operation and Development |
Publisher | : Organisation for Economic Co-operation and Development ; [Montréal : Renouf] |
Total Pages | : |
Release | : 1981 |
Genre | : Chemical industry |
ISBN | : 9789264122215 |
Download OECD Guidelines for Testing of Chemicals Book in PDF, ePub and Kindle
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2018-06-27 |
Genre | : |
ISBN | : 9264284168 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than death/moribundity is used as an endpoint, and ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 29 |
Release | : 2008-10-16 |
Genre | : |
ISBN | : 9264071040 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure Book in PDF, ePub and Kindle
The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2009-09-08 |
Genre | : |
ISBN | : 9264070605 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 13 |
Release | : 2017-10-09 |
Genre | : |
ISBN | : 9264070583 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 24 |
Release | : 2002-05-10 |
Genre | : |
ISBN | : 926407841X |
Download OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on Acute Oral Toxicity Testing Book in PDF, ePub and Kindle
This Guidance Document provides information for both the regulated community and regulators to assist with the choice of the most appropriate Guideline to enable particular data requirements to be met while reducing the number of animals used and animal suffering.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 13 |
Release | : 2008-10-16 |
Genre | : |
ISBN | : 9264070680 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...