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Ocular Circulation and Neovascularization

Ocular Circulation and Neovascularization
Author: D. Benezra
Publisher: Springer Science & Business Media
Total Pages: 555
Release: 2012-12-06
Genre: Medical
ISBN: 9400933371
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Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches. Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously, it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif·ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational, ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand & upportofArnallPatz, Bob Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook

Ocular Blood Flow

Ocular Blood Flow
Author: Leopold Schmetterer
Publisher: Springer Science & Business Media
Total Pages: 451
Release: 2012-06-14
Genre: Medical
ISBN: 3540694692
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Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.

Ocular Blood Flow in Glaucoma

Ocular Blood Flow in Glaucoma
Author: Robert N. Weinreb
Publisher: Kugler Publications
Total Pages: 177
Release: 2009
Genre: Glaucoma
ISBN: 9062992226
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This is the sixth World Glaucoma Association Consensus. The relationship between ocular blood flow and glaucoma has been discussed for more than a century, and still it uniformly fuels debates at glaucoma meetings throughout the world. Clearly, the results of this report will have broad and significant impact on glaucoma research and clinical practice. The global faculty, consisting of leading authorities on the scientific and clinical aspects of ocular blood flow, have met in Fort Lauderdale on May 2, 2009 to discuss the reports and refine the consensus statements.

The Retinal Circulation

The Retinal Circulation
Author: George N. Wise
Publisher: HarperCollins Publishers
Total Pages: 584
Release: 1971
Genre: Medical
ISBN:
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The Ocular Circulation

The Ocular Circulation
Author: Jeffrey W. Kiel
Publisher: Biota Publishing
Total Pages: 83
Release: 2011-02-01
Genre: Medical
ISBN: 1615041699
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This presentation describes the unique anatomy and physiology of the vascular beds that serve the eye. The needs for an unobstructed light path from the cornea to the retina and a relatively fixed corneal curvature and distance between refractive structures pose significant challenges for the vasculature to provide nutrients and remove metabolic waste. To meet these needs, the ocular vascular beds are confined to the periphery of the posterior two thirds of the eye and a surrogate circulation provides a continuous flow of aqueous humor to nourish the avascular cornea, lens and vitreous compartment. The production of aqueous humor (and its ease of egress from the eye) also generates the intraocular pressure (IOP), which maintains the shape of the eye. However, the IOP also exerts a compressing force on the ocular blood vessels that is higher than elsewhere in the body. This is particularly true for the intraocular veins, which must have a pressure higher than IOP to remain patent, and so the IOP is the effective venous pressure for the intraocular vascular beds. Consequently, the ocular circulation operates at a lower perfusion pressure gradient than elsewhere in the body and is more at risk for ischemic damage when faced with low arterial pressure, particularly if IOP is elevated. This risk and the specialized tissues of the eye give rise to the fascinating physiology of the ocular circulations.

Atlas of Ocular Blood Flow

Atlas of Ocular Blood Flow
Author: Alon Harris
Publisher: Butterworth-Heinemann
Total Pages: 150
Release: 2003
Genre: Medical
ISBN:
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This text examines the vascular anatomy and physiology of the eye as well as the assessment of ocular circulation in health and disease. It offers a cutting-edge analysis of the eye's blood supply and how it is affected by conditions such as glaucoma, age-related macular degeneration, and diabetic retinopathy. 425 illustrations -- including 250 in full color -- detail anatomy, techniques, the results of imaging studies, and more. Provides a cutting-edge analysis of the eye's blood supply and how it is affected by conditions such as glaucoma, age-related macular degeneration, and diabetic retinopathy. Describes the latest noninvasive methods for measuring blood flow, and explains how to use this advanced technology to evaluate patients. Features more than 435 illustrations-over 345 in full color-that richly depict anatomy, techniques, imaging findings, and more. Offers the expertise of authors who have been involved extensively in the design and clinical application of new technologies for the assessment of ocular circulation.

Control of Ocular Circulation

Control of Ocular Circulation
Author: Esmeralda Delgado
Publisher: LAP Lambert Academic Publishing
Total Pages: 108
Release: 2015-04-20
Genre:
ISBN: 9783659698262
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In this volume Prof. Dr. Esmeralda Delgado summarizes the content of the research that led to her PhD thesis under the theme of the local control of ocular circulation in an isolated model of rabbit eye. The eye is our window to the world and the loss of its functionality has a profound and devastating effect on the way we interact with the environment around us. The ocular circulation comprises two compartments: a retinal and a choroidal compartment and the control of ocular circulation is a vital component in the maintenance of retinal homeostasis. Understanding the local control mechanisms is a key factor to the development of effective treatments to restore a normal retinal blood flow in disease situations. In this work we developed an experimental model of isolated rabbit eye to help clarifying the local mechanisms of control of ocular circulation, independently of other interferences present in an "in vivo" model. This in situ model mimics most of the vascular connections present in the living animal, allowing the study of the intrinsic mechanisms of regulation of ocular circulation yet eliminating neural influences.

Ocular Vascular Occlusive Disorders

Ocular Vascular Occlusive Disorders
Author: Sohan Singh Hayreh
Publisher: Springer
Total Pages: 863
Release: 2015-02-18
Genre: Medical
ISBN: 3319127810
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This book provides a comprehensive account of the pathogenesis, clinical features, and management of ocular vascular occlusive disorders, with the focus very much on the scientific evidence. This offers a sound basis for addressing the many controversies that surround these disorders, which collectively constitute the most common cause of visual impairment or blindness. The book is divided into two sections, the first of which addresses the basic science and encompasses vascular anatomy, blood supply and flow, and retinal tolerance time to acute ischemia. The second, clinical, section covers the presentation, clinical features, diagnosis, and treatment of the full range of vascular occlusive disorders of the retina, the choroid, the anterior segment of the eye, ophthalmic manifestations of carotid artery disease and the optic nerve. Ocular Vascular Occlusive Disorders, written by a distinguished world leader in the field, will be invaluable for general ophthalmologists, and particularly for retina specialists, neuro-ophthalmologists, and researchers.

A Case-Based Guide to Eye Pain

A Case-Based Guide to Eye Pain
Author: Michael S. Lee
Publisher: Springer
Total Pages: 286
Release: 2017-11-15
Genre: Medical
ISBN: 3319651218
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Diagnosing a patient with unexplained ocular pain can be time-consuming and difficult, but taking an anatomic approach and excluding causes along the way can aid in the diagnosis. This book provides the reader with a systematic evaluation plan for these cases, written and edited by leaders in the field. A Case-Based Guide to Eye Pain is written for both ophthalmologists and neuro-ophthalmologists since there are not enough neuro-ophthalmologists to treat the number of patients with unexplained ocular pain and general ophthalmologists are having to take on the diagnosis and treatment of these patients. Organized in an easy-to-use manner, each case covers the following key elements: the chief complaint, history of the present illness, the examination, assessment and plan, follow-up, alternate perspective, summary points, and key references. Tables are also available to help the reader rapidly sort through cases that may apply to a sign, symptom, historical feature, diagnostic test or treatment option. This allows the practitioner who has a patient with a particular concern to use the tables to identify a case discussion. Additionally, A Case-based Guide to Eye Pain includes an appendices with the general approach to eye pain and anatomy of the trigeminal pathway and its relation to eye pain.