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Novel Drug Targets With Traditional Herbal Medicines

Novel Drug Targets With Traditional Herbal Medicines
Author: Fatma Tuğçe Gürağaç Dereli
Publisher: Springer Nature
Total Pages: 579
Release: 2022-09-29
Genre: Medical
ISBN: 3031077539

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This book collects information about the most popular ethnomedicinal plants, which are common in Turkey and around the world. It presents the ethnopharmacological records, in vivo and in vitro studies, side effects, chemical compositions and clinical studies of these medicinal plants. Its special focus is on the novel drug targets for disease and their possible mechanisms of action. It covers botanical descriptions the status of the plants, and food or drug interactions including precautions and warnings about the plants and the available market products. It provides an explanation of recorded and known plant administration dosages. Also, the gap between the traditional practice and scientific/clinical evidences in the use of ethnomedicinal plant is acknowledged. It is well known that traditional knowledge of the use of the medicinal plants in therapy is an important resource for the discovery of novel treatment options and drug targets. The main purpose of this book is to draw attention to ethnomedicinal plant species. Data on the therapeutic potentials of these medicinal plants can now be accessed from a single source. It provides an important resource for future research opportunities for harnessing the full potential of these plants.


Drug Discovery & Development

Drug Discovery & Development
Author: Bhushan Patwardhan
Publisher: New India Publishing
Total Pages: 368
Release: 2007
Genre: Medical
ISBN: 9788189422295

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While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.


Natural Medicines

Natural Medicines
Author: Dilip Ghosh
Publisher: CRC Press
Total Pages: 632
Release: 2019-07-18
Genre: Medical
ISBN: 1351741357

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Globally, natural medicine has been considered as an important alternative to modern allopathic medicine. Although natural medicines are popular in society, only limited medicinal herbs have been scientifically evaluated for their potential in medical treatment. This book connects various aspects of the complex journey from traditional medicine to modern medicine. It provides information on topics including global regulations and regulatory hurdles, diverse nutritional challenges and potential health benefits, novel food innovations especially seed-to-clinic approaches, and future trends. FEATURES • Provides information on sustainable use of natural products in the development of new drugs and clinically validated herbal remedies • Discusses issues on evaluation and clinical aspects of herbal medicine, promotion and development, safety evaluation, metabolite profiling, biomarker analysis, formulation, and stability testing • Describes traditional uses of natural medicine through identification, isolation and structural characterization of their active components • Elucidates mechanisms of biological action, adverse effects and identification of their molecular targets of natural medicine • Multidisciplinary appeal including chemistry, pharmacology, pharmacognosy and cell and molecular biology, as well as integration with clinical medicine This book serves as an essential guide for individuals researching natural medicines, and industry employees in areas including drug development, pharmacology, natural products chemistry, clinical efficacy, ethnopharmacology, pharmacognosy, phytotherapy, phyto-technology and herbal science.


Drug Discovery And Development

Drug Discovery And Development
Author: Bhushan Patwardhan
Publisher: Nipa
Total Pages: 0
Release: 2023-06-14
Genre: Medical
ISBN: 9788119072859

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While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.


Herbal Medicine in Depression

Herbal Medicine in Depression
Author: Clara Grosso
Publisher: Springer
Total Pages: 589
Release: 2016-05-30
Genre: Medical
ISBN: 3319140213

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This book is written for researchers, undergraduate students and postgraduate students, physicians and traditional medicine practitioners who develop research in the field of neurosciences, phytochemistry and ethnopharmacology or can be useful for their practice. Topics discussed include the description of depression, its biochemical causes, the targets of antidepressant drugs, animal and cell models commonly used in the research of this pathology, medicinal plants and bioactive compounds with antidepressant activity used in traditional medicine, advances in nanotechnology for drug delivery to the brain and finally the future challenges for researchers studying this pathology.


Evidence-Based Validation of Herbal Medicine

Evidence-Based Validation of Herbal Medicine
Author: Pulok K. Mukherjee
Publisher: Elsevier
Total Pages: 858
Release: 2022-07-12
Genre: Business & Economics
ISBN: 0323984568

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Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more


Recent Advances in Herbal Drug Research and Therapy

Recent Advances in Herbal Drug Research and Therapy
Author: Arunabha Ray
Publisher:
Total Pages: 467
Release: 2010
Genre: Herbs
ISBN: 9789380026978

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Traditional systems of medicine are fast emerging as viable alternatives to modern medical science. Further, in recent years the emphasis on botanicals as source for drug discovery and development has been realized globally. Added to this, the safer profile of herbal drugs combined with their low costs make them ideal targets for newer drugs. As in the modern system of medicine, viz. allopathy, herbal drugs form an inseparable part of the management of various disorders. The concept of scientific validation of the basis of traditional uses of herbal medicines has given birth to a new concept of reverse pharmacology, and interactions between traditional and modern systems of medicine are being increasingly encouraged. Recent Trends in Herbal Drug Research and Therapy showcases some of these crucial and emerging issues relating to herbal drugs. This compilation is a judicious combination of research and conventional aspects on the subject of herbal drugs, their pharmacology and therapeutic applications. Some very relevant general and systemic pharmacological as well as toxicological aspects have been highlighted by some of the leading experts in this field. The book will be of interest to students, scientists, teachers and other health professionals in the area of pharmacology, toxicology and allied health sciences. Spread in 26 chapters the book broadly focuses on: * Standardization and quality control of herbal drugs * Regulatory issues like ethics and pharmacovigilance with herbals * Clinical research with herbal drugs * Herbogenomics * Herb-drug interactions * Potential therapeutics uses of herbal drugs focusing on various systemic disorders of cardiorespiratory, endocrinal, neuropsychiatric gastrointestinal systems and cancer * Herbal drugs and environmental toxicology


Natural Products and Drug Discovery

Natural Products and Drug Discovery
Author: Subhash C. Mandal
Publisher: Elsevier
Total Pages: 778
Release: 2018-02-16
Genre: Science
ISBN: 0081021046

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Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout


Ethnopharmacology in Central and Eastern Europe in the Context of Global Research Developments

Ethnopharmacology in Central and Eastern Europe in the Context of Global Research Developments
Author: Judit Hohmann
Publisher: Frontiers Media SA
Total Pages: 356
Release: 2019-07-25
Genre:
ISBN: 2889458903

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.


Traditional Herbal Medicine Research Methods

Traditional Herbal Medicine Research Methods
Author: Willow J.H. Liu
Publisher: John Wiley & Sons
Total Pages: 393
Release: 2011-03-29
Genre: Science
ISBN: 0470922664

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This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic study and analysis of herbal medicines in general – including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products.