Normal And Malignant Hematopoiesis PDF Download
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Author | : Enrico Mihich |
Publisher | : Springer Science & Business Media |
Total Pages | : 251 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461519276 |
Download Normal and Malignant Hematopoiesis Book in PDF, ePub and Kindle
''An exciting glance at key issues in contemporary hematopoiesis.'' -The Quarterly Review of Biology
Author | : Patrick Joseph Walsh |
Publisher | : |
Total Pages | : 46 |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Modeling Normal and Malignant Hematopoiesis Using Human Pluripotent Stem Cells Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 172 |
Release | : 2013 |
Genre | : |
ISBN | : 9789036763905 |
Download Epigenetic Regulation of Normal and Malignant Hematopoiesis Book in PDF, ePub and Kindle
Author | : Thanyaphong Na Nakorn |
Publisher | : |
Total Pages | : 266 |
Release | : 2002 |
Genre | : |
ISBN | : |
Download Myeloid Progenitors in Normal and Malignant Hematopoiesis Book in PDF, ePub and Kindle
Author | : Katya Ravid |
Publisher | : John Wiley & Sons |
Total Pages | : 640 |
Release | : 2003-11-04 |
Genre | : Science |
ISBN | : 0471461067 |
Download Transcription Factors Book in PDF, ePub and Kindle
Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Author | : Jozef Henricus Jansen |
Publisher | : |
Total Pages | : 133 |
Release | : 1992 |
Genre | : |
ISBN | : |
Download Interleukin-4 Book in PDF, ePub and Kindle
Author | : Laurent Degos |
Publisher | : CRC Press |
Total Pages | : 1492 |
Release | : 2004-12-14 |
Genre | : Medical |
ISBN | : 1841841455 |
Download Textbook of Malignant Hematology Book in PDF, ePub and Kindle
The Second Edition of this successful title has been fully revised and updated and now includes expanded sections on normal and malignant haematopoiesis, offering a thorough review of the molecular and cellular processes involved in malignancy, developments in diagnostic techniques and treatment, concluding with discussion of treatment of individual diseases, late effects of therapy and supportive care. Short Contents
Author | : Daniel Lipka |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
Download Molecular Dissection of Normal and Malignant Hematopoiesis Identifies Therapeutic Targets in Myeloid Neoplasms Book in PDF, ePub and Kindle
Author | : Claire Mazumdar |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Functional Consequences of Cohesin Complex Mutations on Normal and Malignant Hematopoiesis Book in PDF, ePub and Kindle
Recent studies have identified recurrent mutations in all components of the cohesin complex in acute myeloid leukemia and other myeloid malignancies, and, importantly, have shown these mutations to occur early in disease pathogenesis and in pre-leukemic hematopoietic stem cells. Here, we investigate the impact of these mutations on hematopoiesis and demonstrate that introduction of cohesin mutants into normal human hematopoietic stem and progenitor cells (HSPC) results in blocked differentiation and enforcement of stem cell programs both in vitro and in vivo. These effects were cell context dependent, restricted to immature HSPC populations. Cohesin mutants selectively increased chromatin accessibility and likelihood of occupancy at binding sites for transcription factors known to regulate HSPC including ERG, GATA2, and RUNX1 as measured by ATAC-Seq and ChIP-Seq. Furthermore, epistasis experiments showed that silencing of these transcription factors 2in which mutant cohesin impairs hematopoietic differentiation and aberrantly enforces stem cell programs through the modulation of HSPC chromatin accessibility and transcription factor activity.
Author | : Florian Kuchenbauer |
Publisher | : |
Total Pages | : |
Release | : 2017* |
Genre | : |
ISBN | : |
Download The Role of MicroRNAs in Normal and Malignant Hematopoiesis Book in PDF, ePub and Kindle