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Smokeless Tobacco and Some Tobacco-specific N-nitrosamines

Smokeless Tobacco and Some Tobacco-specific N-nitrosamines
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
Total Pages: 642
Release: 2007
Genre: Medical
ISBN: 9283212894

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This eighty-ninth volume of the IARC Monographs is the third and last of a series on tobacco-related agents. Volume 83 reported on the carcinogenicity of tobacco smoke and involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC 2004a). Volume 85 summarized the evidence on the carcinogenic risk of chewing betel quid with and without tobacco (IARC 2004b). That volume explored the variety of products chewed in South Asia and other parts of the word that contain areca nut in combination with other ingredients, often including tobacco. In this eighty-ninth volume, the carcinogenic risks associated with the use of smokeless tobacco, including chewing tobacco and snuff, are considered in a first monograph. The second monograph reviews some tobacco-specific nitrosamines. These agents were evaluated earlier in Volume 37 of the Monographs (IARC 1985) and information gathered since that time has been summarized and evaluated.


Tobacco-Specific N-Nitrosamines Recent Advances

Tobacco-Specific N-Nitrosamines Recent Advances
Author: Roger O. McClellan
Publisher: CRC Press
Total Pages: 154
Release: 1996-05-10
Genre: Medical
ISBN: 9780849311567

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This remarkable book provides updates on various aspects of tobacco - its chemical and biological nature, and its physiological effects.


Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines

Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: IARC
Total Pages: 354
Release: 2004
Genre: Health & Fitness
ISBN: 9789283212850

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A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis


Mutation, Cancer, and Malformation

Mutation, Cancer, and Malformation
Author: Ernest H.Y. Chu
Publisher: Springer Science & Business Media
Total Pages: 852
Release: 2012-12-06
Genre: Science
ISBN: 1461323991

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During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.


Tobacco-Specific N-Nitrosamines Recent Advances

Tobacco-Specific N-Nitrosamines Recent Advances
Author: Roger O. McClellan
Publisher: CRC Press
Total Pages: 85
Release: 2017-10-06
Genre: Medical
ISBN: 1351408089

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This remarkable book provides updates on various aspects of tobacco - its chemical and biological nature, and its physiological effects.


How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Total Pages: 728
Release: 2010
Genre: Government publications
ISBN:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.


Nitrosamines and Related N-nitroso Compounds

Nitrosamines and Related N-nitroso Compounds
Author: Richard N. Loeppky
Publisher:
Total Pages: 410
Release: 1994
Genre: Medical
ISBN:

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Investigates the compound formation, bioactivation, and detoxification of the N-nitroso group of compounds, which increasingly appears to be implicated in human carcinogenesis. The topics include exposure, formation, and blocking; nitric oxide; nitrosamine; toxic, mutagenic, and carcinogenic effects; and reactive intermediates. The 45 papers largely report on research rather than review the literature. The symposium that occasioned them was in Washington, DC, in August 1992. Annotation copyright by Book News, Inc., Portland, OR


Nitrite Curing of Meat

Nitrite Curing of Meat
Author: Ronald B. Pegg
Publisher: John Wiley & Sons
Total Pages: 280
Release: 2008-06-02
Genre: Technology & Engineering
ISBN: 0470384867

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Meat has been treated for centuries with rock salt as a means of preservation. However, only one century has passed since the German researchers, Polenske in 1891, Kisshalt in 1899, and Lehmann in 1899, discovered that the active component in the curing process was nitrite. Soon after the role of nitrite as a meat curing agent was revealed, government regulators placed guidelines on the level of nitrite and nitrate permitted for use in cured meat formulations. In the late 1960s and early 1970s, the development of the so-called "nitrite problem" surfaced because of the detection of N-nitrosamines in processed meats. The industry was in an uproar and the issue was of paramount interest to scientists and the public. A major technical advance in the analytical technique for N-nitrosamine detection was achieved when Thermo Electron of Waltham, Massachusetts introduced the thermal energy analyzer (TEA). This unit allowed the screening of a large number of samples for nitrosamine with only a minimum preparation. The role of nitrite in revealing the desired and unique flavor of cured products, perhaps by suppressing the formation of lipid oxidation products was another development in revealing other properties of nitrite. Above all, the antimicrobial role of nitrite, together with salt, had a major influence on the popularity of nitrite/nitrate in food preservation. This book provides a review of the desirable attributes which sodium nitrite confers to meat during processing, as well as drawbacks of nitrite usage, i.e., the presence of N-nitrosoamines. In addition, solutions for the curing of meat without the use of nitrite are presented. An examination of a multicomponent nitrite-free curing system entailing the color, flavor, and microbial protection of such a system is given.