Nitric Acid in Experimental Sepsis
Author | : Pieter Lee Dahm |
Publisher | : |
Total Pages | : 152 |
Release | : 1998 |
Genre | : Nitric oxide |
ISBN | : |
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Author | : Pieter Lee Dahm |
Publisher | : |
Total Pages | : 152 |
Release | : 1998 |
Genre | : Nitric oxide |
ISBN | : |
Author | : Günther Schlag |
Publisher | : Springer Science & Business Media |
Total Pages | : 461 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642586309 |
At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.
Author | : Øystein Anders Strand |
Publisher | : |
Total Pages | : 96 |
Release | : 1999 |
Genre | : |
ISBN | : 9788299509008 |
Author | : Johannes Adrianus Maria Avontuur |
Publisher | : |
Total Pages | : 194 |
Release | : 1998 |
Genre | : |
ISBN | : 9789090118253 |
Author | : H. Redl |
Publisher | : Springer Science & Business Media |
Total Pages | : 398 |
Release | : 1998-11 |
Genre | : Health & Fitness |
ISBN | : 9783764358778 |
This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation-/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with experimental models as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.
Author | : M.P. Fink |
Publisher | : Springer Science & Business Media |
Total Pages | : 435 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642799205 |
Nitric Oxide (NO) is a free radical, a gas, and a pluripotent product of mammalian cells. Only a few years ago, scientific discussions of NO were largely held in the context of the chemistry of air pollution. Now, however, the great significance of NO as a signalling and cytotoxic molecule has captured the attention of the biomedical community. This book provides a very up-to-date review of the role of NO in sepsis and ARDS. Consideration is given to NO both as a pathophysiologic mediator as well as a therapeutic agent. An internationally recognized group of scientists and clinicians have contributed chapters dealing with cutting-edge science and practical clinical strategies. Numerous tables and charts have been included to aid the reader in understanding this fascinating and important subject.
Author | : Lucia Morbidelli |
Publisher | : Academic Press |
Total Pages | : 372 |
Release | : 2019-02-09 |
Genre | : Medical |
ISBN | : 0128172797 |
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
Author | : René Holzheimer |
Publisher | : |
Total Pages | : 880 |
Release | : 2001 |
Genre | : Medical |
ISBN | : |
Author | : Daniela Salvemini |
Publisher | : Springer |
Total Pages | : 308 |
Release | : 2013-03-11 |
Genre | : Medical |
ISBN | : 3034882416 |
Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field.
Author | : Robert D. Stevens |
Publisher | : Cambridge University Press |
Total Pages | : 457 |
Release | : 2013-09-19 |
Genre | : Medical |
ISBN | : 1107434424 |
Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.