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| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 419 |
| Release | : 2012-10-22 |
| Genre | : Medical |
| ISBN | : 012387016X |
Download New Perspectives of Central Nervous System Injury and Neuroprotection Book in PDF, ePub and Kindle
Central nervous system (CNS) diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis affect a large number of populations worldwide for which no suitable cure is currently available. In addition, stroke, nanoparticle intoxication, diabetes, hypertension, and psychostimulant abuse either alone or in combination are capable of inducing potential brain damage. Thus, there is an urgent need to expand our knowledge to find suitable therapeutic strategies to enhance neurorepair processes in such diseases.This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection.This volume of International Review of Neurobiology is the first to discuss novel therapeutic strategies in situations of neurological disorders in combination with different co-morbidity factors. Reviews written by experts in such a way that provides basic knowledge for beginners and advanced information for researchers and experts New aspects of Neurodegenerative diseases such as; Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis are presented with the latest therapeutic measures Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time
| Author | : Kewal K. Jain |
| Publisher | : Springer |
| Total Pages | : 857 |
| Release | : 2019-05-15 |
| Genre | : Medical |
| ISBN | : 1493994654 |
Download The Handbook of Neuroprotection Book in PDF, ePub and Kindle
This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 184 |
| Release | : 2017-11-11 |
| Genre | : Science |
| ISBN | : 0128123826 |
Download Nanomedicine in Central Nervous System Injury and Repair Book in PDF, ePub and Kindle
Nanomedicine in Central Nervous System Injury and Repair (IRN), Volume 137, the latest release in the International Review of Neurobiology series presents comprehensive chapters that cover a broad range of topics, including, but not limited to, how Diabetes exacerbates methamphetamine induced blood-brain barrier breakdown, edema formation, oxidative stress and myelin damage, and how Focal blast brain injury induces rapid edema formation, blood-brain barrier breakdown and intensive cellular damage. In addition, the Neuroprotective effects of a multimodal drug cerebrolysin are explored, as is how Nanowired cerebrolysin potentiates neuroprotective effects of histamine H3 receptor inverse agonist and antagonist with partial H4 agonist in Alzheimer's Disease. This series reviews current knowledge and understanding on how to repair the damaged spinal cord and brain with nanomedicine, detailing new therapeutic advances and providing a starting point for researchers and practitioners entering the field. Provides cutting-edge research on the damaged spinal cord and brain Presents new therapeutic advances Reviews current knowledge and understanding
| Author | : Frank W. Marcoux |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 509 |
| Release | : 2013-11-11 |
| Genre | : Medical |
| ISBN | : 3662062747 |
Download CNS Neuroprotection Book in PDF, ePub and Kindle
"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr.
| Author | : Hari Shanker Sharma |
| Publisher | : Academic Press |
| Total Pages | : 420 |
| Release | : 2012-07-10 |
| Genre | : Medical |
| ISBN | : 0123869862 |
Download New Perspectives of Central Nervous System Injury and Neuroprotection Book in PDF, ePub and Kindle
Annotation Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Reviews written by experts in such a way thatprovides basic knowledge for beginners and advanced information for researchers and experts. New aspects of Neurodegenerative diseasessuch as;Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis are presented with thelatest therapeutic measures. Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time.
| Author | : P. Bar |
| Publisher | : CRC Press |
| Total Pages | : 584 |
| Release | : 1997-06-17 |
| Genre | : Medical |
| ISBN | : 9780824798765 |
Download Neuroprotection in CNS Diseases Book in PDF, ePub and Kindle
In response to rapidly evolving areas in clinical and laboratory neuroscience, this timely resource provides in-depth coverage of protective measures for acute and chronic neurodegenerative diseases, from the physiology and pathophysiology of the central and peripheral nervous system to present and future developments and applications of effective neuroprotective strategies.
| Author | : Mathias Bähr |
| Publisher | : Wiley-Blackwell |
| Total Pages | : 390 |
| Release | : 2006-03-06 |
| Genre | : Medical |
| ISBN | : 3527604316 |
Download Neuroprotection Book in PDF, ePub and Kindle
In this first book to cover model systems, molecular mechanisms and clinical trials all in one volume internationally renowned scientists and clinicians provide a comprehensive treatment of neuroprotective strategies for all important neurological disorders. Following an overview of neurodegenerative, traumatic, and ischemic disorders, the book goes on to cover in vitro and animal model systems as well as cellular and molecular mechanisms. An extremely helpful analysis of clinical studies explains reasons for their success and failure, and the whole is rounded off with a look at the current challenges and hopes for the development of effective treatment strategies in the future.
| Author | : William M. Reichert |
| Publisher | : CRC Press |
| Total Pages | : 300 |
| Release | : 2007-12-17 |
| Genre | : Medical |
| ISBN | : 1420009303 |
Download Indwelling Neural Implants Book in PDF, ePub and Kindle
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
| Author | : António Salgado |
| Publisher | : Elsevier |
| Total Pages | : 712 |
| Release | : 2020-06-10 |
| Genre | : Medical |
| ISBN | : 0128180854 |
Download Handbook of Innovations in Central Nervous System Regenerative Medicine Book in PDF, ePub and Kindle
Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path
| Author | : Daniel Laskowitz |
| Publisher | : CRC Press |
| Total Pages | : 388 |
| Release | : 2016-04-21 |
| Genre | : Medical |
| ISBN | : 1498766579 |
Download Translational Research in Traumatic Brain Injury Book in PDF, ePub and Kindle
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
