New Horizons In Predictive Toxicology PDF Download
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| Author | : Alan G. E. Wilson |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 711 |
| Release | : 2012 |
| Genre | : Medical |
| ISBN | : 1849730512 |
Download New Horizons in Predictive Toxicology Book in PDF, ePub and Kindle
The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.
| Author | : Alan G E Wilson |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 422 |
| Release | : 2015-11-20 |
| Genre | : Medical |
| ISBN | : 1782622373 |
Download New Horizons in Predictive Drug Metabolism and Pharmacokinetics Book in PDF, ePub and Kindle
Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities. Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.
| Author | : Friedlieb Pfannkuch |
| Publisher | : John Wiley & Sons |
| Total Pages | : 430 |
| Release | : 2015-01-20 |
| Genre | : Medical |
| ISBN | : 3527336087 |
Download Predictive Toxicology Book in PDF, ePub and Kindle
Ein moderner integrierter Ansatz für die Sicherheitsprüfung in der Arzneimittelentwicklung: Dieses Praktikerbuch behandelt In-silico- und In-vitro-Methoden sowie den Einsatz von Biomarkern, mit denen bei kleinen Arzneistoffmolekülen und Biologika frühzeitig und zuverlässig Toxizitäts-Screenings durchgeführt werden können.
| Author | : Jinghai J. Xu |
| Publisher | : Cambridge University Press |
| Total Pages | : |
| Release | : 2010-09-27 |
| Genre | : Medical |
| ISBN | : 1139493094 |
Download Predictive Toxicology in Drug Safety Book in PDF, ePub and Kindle
According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), 'developing new scientific approaches to detecting, understanding, predicting and preventing adverse events' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body.
| Author | : Jerry B. Hook |
| Publisher | : CRC Press |
| Total Pages | : 588 |
| Release | : 1993-06-30 |
| Genre | : Medical |
| ISBN | : 9780881678857 |
Download Toxicology of the Kidney Book in PDF, ePub and Kindle
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
| Author | : Andrew G. Mtewa |
| Publisher | : John Wiley & Sons |
| Total Pages | : 444 |
| Release | : 2020-12-22 |
| Genre | : Science |
| ISBN | : 1119650232 |
Download Poisonous Plants and Phytochemicals in Drug Discovery Book in PDF, ePub and Kindle
Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career
| Author | : Mark T. D. Cronin |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 689 |
| Release | : 2010 |
| Genre | : Medical |
| ISBN | : 1849730040 |
Download In Silico Toxicology Book in PDF, ePub and Kindle
This book defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 217 |
| Release | : 2007-11-05 |
| Genre | : Nature |
| ISBN | : 0309151732 |
Download Toxicity Testing in the 21st Century Book in PDF, ePub and Kindle
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
| Author | : Antonio Peña-Fernández |
| Publisher | : CRC Press |
| Total Pages | : 531 |
| Release | : 2021-12-21 |
| Genre | : Medical |
| ISBN | : 1351398016 |
Download Toxicology for the Health and Pharmaceutical Sciences Book in PDF, ePub and Kindle
There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.
| Author | : Christoph Helma |
| Publisher | : CRC Press |
| Total Pages | : 522 |
| Release | : 2005-03-17 |
| Genre | : Medical |
| ISBN | : 0849350352 |
Download Predictive Toxicology Book in PDF, ePub and Kindle
A comprehensive overview of techniques and systems currently utilized in predictive toxicology, this reference presents an in-depth survey of strategies, algorithms, and prediction methods to select, calculate, and represent the features and properties of chemical structures in biological systems. It provides sources of high-quality toxicity data, the most important commercial and noncommercial predictive toxicology programs, and advanced technologies in computational chemistry, biology, statistics, and data mining. Predictive Toxicology explores applications that go beyond classical structure-activity relationships and discusses programs such as OncoLogic, META, MC4PC, PASS, and lazar.
