Neutron Tube Design Study For Boron Neutron Capture Therapyapplication PDF Download
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Author | : |
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Total Pages | : 5 |
Release | : 1999 |
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Download Neutron Tube Design Study for Boron Neutron Capture Therapy Application Book in PDF, ePub and Kindle
Radio-frequency (RF) driven ion sources are being developed in Lawrence Berkeley National Laboratory (LBNL) for sealed-accelerator-tube neutron generator application. By using a 5-cm-diameter RF-driven multicusp source H yields over 95% have been achieved. These experimental findings will enable one to develop compact neutron generators based on the D-D or D-T fusion reactions. In this new neutron generator, the ion source, the accelerator and the target are all housed in a sealed metal container without external pumping. Recent moderator design simulation studies have shown that 14 MeV neutrons could be moderated to therapeutically useful energy ranges for boron neutron capture therapy (BNCT). The dose near the center of the brain with optimized moderators is about 65% higher than the dose obtained from a typical neutron spectrum produced by the Brookhaven Medical Research Reactor (BMRR), and is comparable to the dose obtained by other accelerator-based neutron sources. With a 120 keV and 1 A deuteron beam, a treatment time of (almost equal to)35 minutes is estimated for BNCT.
Author | : |
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Total Pages | : |
Release | : 1998 |
Genre | : |
ISBN | : |
Download Neutron Tube Design Study for Boron Neutron Capture TherapyApplication Book in PDF, ePub and Kindle
Radio-frequency (RF) driven ion sources are being developed in Lawrence Berkeley National Laboratory (LBNL) for sealed-accelerator-tube neutron generator application. By using a 5-cm-diameter RF-driven multicusp source H yields over 95% have been achieved. These experimental findings will enable one to develop compact neutron generators based on the D-D or D-T fusion reactions. In this new neutron generator, the ion source, the accelerator and the target are all housed in a sealed metal container without external pumping. Recent moderator design simulation studies have shown that 14 MeV neutrons could be moderated to therapeutically useful energy ranges for boron neutron capture therapy (BNCT). The dose near the center of the brain with optimized moderators is about 65% higher than the dose obtained from a typical neutron spectrum produced by the Brookhaven Medical Research Reactor (BMRR), and is comparable to the dose obtained by other accelerator-based neutron sources. With a 120 keV and 1 A deuteron beam, a treatment time of (almost equal to)35 minutes is estimated for BNCT.
Author | : Otto K. Harling |
Publisher | : Springer Science & Business Media |
Total Pages | : 340 |
Release | : 2013-03-08 |
Genre | : Medical |
ISBN | : 1468458027 |
Download Neutron Beam Design, Development, and Performance for Neutron Capture Therapy Book in PDF, ePub and Kindle
For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.
Author | : R.F. Barth |
Publisher | : Springer Science & Business Media |
Total Pages | : 776 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461529786 |
Download Advances in Neutron Capture Therapy Book in PDF, ePub and Kindle
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Author | : M. Frederick Hawthorne |
Publisher | : Springer |
Total Pages | : 1389 |
Release | : 2013-11-11 |
Genre | : Medical |
ISBN | : 1461512859 |
Download Frontiers in Neutron Capture Therapy Book in PDF, ePub and Kindle
Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Author | : Steven W. Martsolf |
Publisher | : |
Total Pages | : 148 |
Release | : 1993 |
Genre | : Boron-neutron capture therapy |
ISBN | : |
Download Design and Implementation of a Boron Neutron Capture Therapy Research Facility and Dosimetry Program Book in PDF, ePub and Kindle
Author | : Michael Christian Dobelbower |
Publisher | : |
Total Pages | : 438 |
Release | : 1997 |
Genre | : |
ISBN | : |
Download An Integrated Design of an Accelerator-based Neutron Source for Boron Neutron Capture Therapy Book in PDF, ePub and Kindle
Author | : Andrew E. Hawk |
Publisher | : |
Total Pages | : 236 |
Release | : 2003 |
Genre | : |
ISBN | : |
Download A Shielding Design for an Accelerator-based Neutron Source for Boron Neutron Capture Therapy Book in PDF, ePub and Kindle
Author | : United States. Congress. Senate. Committee on Energy and Natural Resources |
Publisher | : |
Total Pages | : 112 |
Release | : 1994 |
Genre | : Medical |
ISBN | : |
Download Boron Neutron Capture Therapy Book in PDF, ePub and Kindle
Author | : Nolan E. Hertel |
Publisher | : |
Total Pages | : |
Release | : 2002 |
Genre | : |
ISBN | : |
Download Fermilab Book in PDF, ePub and Kindle