Neurotrophic Factors PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Neurotrophic Factors PDF full book. Access full book title Neurotrophic Factors.
Author | : Franz Hefti |
Publisher | : Springer Science & Business Media |
Total Pages | : 336 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642599206 |
Download Neurotrophic Factors Book in PDF, ePub and Kindle
The pharmacology of neurotrophic factors is part of the general field called neuroprotection or neurodegeneration, which has emerged during the past two decades. This new broad research area has identified molecular mechanisms that regulate the morphological plasticity of the nervous system and, in con sequence, discovered novel pharmacological approaches to manipulate these processes in disease states. The new, structural neuropharmacology as de scribed in this volume attempts to regulate the anatomic aspects of the nervous system and is perhaps comparable to hardware manipulation in computer systems. In contrast, classical neuropharmacology identified multiple ways to modify the function of existing synapses or ion channels in the nervous system, comparable to software manipulations in the computer field. The pharmacol ogy of neurotrophic factor is at an early stage and has not produced any major drugs yet. However, the first quintessential clinical trials have been carried out in the past two years or are currently in progress. Rapid further advances can be expected. The discovery of nerve growth factor (NGF), the first protein known to promote survival and growth of nerve cells, led to the discovery of a family of related proteins, the neurotrophins and their receptors. This concept was generalized to incorporate many other protein families that are included in the functional definition of neurotrophic factors, i. e. , proteins able to regulate survival and differentiation of neurons.
Author | : Lawrence Kruger |
Publisher | : CRC Press |
Total Pages | : 458 |
Release | : 2009-11-24 |
Genre | : Health & Fitness |
ISBN | : 1439812101 |
Download Translational Pain Research Book in PDF, ePub and Kindle
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Author | : Jeffrey Kordower |
Publisher | : Elsevier |
Total Pages | : 523 |
Release | : 2011-04-28 |
Genre | : Medical |
ISBN | : 0080556981 |
Download CNS Regeneration Book in PDF, ePub and Kindle
This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS
Author | : C. F. Ibanez |
Publisher | : Elsevier Health Sciences |
Total Pages | : 499 |
Release | : 1995-12-22 |
Genre | : Medical |
ISBN | : 1483287955 |
Download Life and Death in the Nervous System Book in PDF, ePub and Kindle
Life and Death in the Nervous System
Author | : Kurt Jellinger |
Publisher | : Springer Science & Business Media |
Total Pages | : 398 |
Release | : 2002-08-20 |
Genre | : Medical |
ISBN | : 9783211837979 |
Download Ageing and Dementia Book in PDF, ePub and Kindle
Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Author | : Yogesh Dwivedi |
Publisher | : CRC Press |
Total Pages | : 485 |
Release | : 2012-06-25 |
Genre | : Medical |
ISBN | : 143983881X |
Download The Neurobiological Basis of Suicide Book in PDF, ePub and Kindle
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Author | : Stephen D Skaper |
Publisher | : Humana Press |
Total Pages | : 421 |
Release | : 2012-02-25 |
Genre | : Medical |
ISBN | : 9781617795374 |
Download Neurotrophic Factors Book in PDF, ePub and Kindle
Nervous system development evolves from the well-orchestrated processes of neural induction, cell proliferation, differentiation, cell migration, survival, and synapse formation. Among these environmental cues, neurotrophic factors are secreted proteins that promote neurite outgrowth, neuronal cell differentiation and survival both in vivo and in vitro. Nerve growth factor (NGF) is the founding and best characterized member of the neurotrophin family of neurotrophic polypeptides. Neurotrophic Factors: Methods and Protocols presents a selection of protocols and procedures which make use of cellular, tissue, and whole animal models which can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. Chapters cover a wide-range of topics such as dealing with the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia co-culture models, and cell-based assays for the evaluation of neuroprotective molecules, as well as assays which can be applied to the study of agents with neuroregenerative potential. Protocols describing viral- and nanoparticle-based delivery methods to neural cells are also presented, following by chapters dealing with organotypic slice culture protocols. Lastly, several chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurotrophic Factors: Methods and Protocols seeks to serve both professionals and novices alike with its well-honed methodologies in an effort to further our knowledge of what has been described as the last frontier of science.
Author | : George J. Siegel |
Publisher | : Lippincott Raven |
Total Pages | : 1216 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Download Basic Neurochemistry Book in PDF, ePub and Kindle
Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Author | : Franz Hefti |
Publisher | : |
Total Pages | : 348 |
Release | : 1998-10-01 |
Genre | : |
ISBN | : 9783642599217 |
Download Neurotrophic Factors Book in PDF, ePub and Kindle
This volume provides the first comprehensive overview of a novel field of neuropharmacology. Neurotrophic factors are currently in clinical trials and there is a broad research effort which aims at alternative administration strategies and at replacing them with small molecule mimetics. The field represents a unique and novel approach to the treatment of neurodegenerative diseases.
Author | : Robert C. Bast, Jr. |
Publisher | : John Wiley & Sons |
Total Pages | : 2004 |
Release | : 2017-03-10 |
Genre | : Medical |
ISBN | : 111900084X |
Download Holland-Frei Cancer Medicine Book in PDF, ePub and Kindle
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates