Network Pharmacology And Traditional Medicine PDF Download
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| Author | : Shao Li |
| Publisher | : Frontiers Media SA |
| Total Pages | : 438 |
| Release | : 2020-10-08 |
| Genre | : Medical |
| ISBN | : 2889660400 |
Download Network Pharmacology and Traditional Medicine Book in PDF, ePub and Kindle
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
| Author | : Shao Li |
| Publisher | : Springer Nature |
| Total Pages | : 480 |
| Release | : 2021-09-29 |
| Genre | : Medical |
| ISBN | : 9811607532 |
Download Network Pharmacology Book in PDF, ePub and Kindle
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
| Author | : Shao Li |
| Publisher | : Frontiers Media SA |
| Total Pages | : 664 |
| Release | : 2022-11-24 |
| Genre | : Science |
| ISBN | : 2832507026 |
Download Network Pharmacology and Traditional Medicine: Setting the New Standards by Combining In silico and Experimental Work Book in PDF, ePub and Kindle
| Author | : Paul U. Unschuld |
| Publisher | : Univ of California Press |
| Total Pages | : 252 |
| Release | : 2009-09-08 |
| Genre | : Social Science |
| ISBN | : 0520944704 |
Download What Is Medicine? Book in PDF, ePub and Kindle
What Is Medicine? Western and Eastern Approaches to Healing is the first comparative history of two millennia of Western and Chinese medicine from their beginnings in the centuries BCE through present advances in sciences like molecular biology and in Western adaptations of traditional Chinese medicine. In his revolutionary interpretation of the basic forces that undergird shifts in medical theory, Paul U. Unschuld relates the history of medicine in both Europe and China to changes in politics, economics, and other contextual factors. Drawing on his own extended research of Chinese primary sources as well as his and others' scholarship in European medical history, Unschuld argues against any claims of "truth" in former and current, Eastern and Western models of physiology and pathology. What Is Medicine? makes an eloquent and timely contribution to discussions on health care policies while illuminating the nature of cognitive dynamics in medicine, and it stimulates fresh debate on the essence and interpretation of reality in medicine's attempts to manage the human organism.
| Author | : H.Gerhard Vogel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 576 |
| Release | : 2010-12-15 |
| Genre | : Medical |
| ISBN | : 3540898905 |
Download Drug Discovery and Evaluation: Methods in Clinical Pharmacology Book in PDF, ePub and Kindle
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
| Author | : Hector Oat |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023 |
| Genre | : Herbs |
| ISBN | : |
Download Network Pharmacology Book in PDF, ePub and Kindle
Network Pharmacology (NP) is a research method that utilises artificial intelligence (AI) and computational models has in recent year been utilised as a tool for research in herbal medicine (HM). For years HM research methods have has faced many drawbacks on how to capture the complexity and synergy of the phytoconstituents in herbal medicine, herb-herb interactions and herb-drug interactions due to the limitations of the reductionist approach of the biomedical paradigm of research. NP offers an approach to research that can accommodate multiple herbal components and multiple targets whereby computational models elucidate potential interactions and areas for further research. Hence this paper poses the questions: “How and to what extent is Network Pharmacology a useful research method for Herbal Medicine research?” To answer this question a systemic review of literature of the methods was carried out. It was found that while NP is a fertile concept for the future of HM and traditional medicine systems research, there are limitations. As a budding new research method for HM, NP lacks standardization and databases used to train AI models are slow to update and can be open access enabling a high chance for misinformation to be created. A conclusion that NP is an approach that utilises various methods rather than a research method in itself is drawn, defining a call for mixed methods in HM research. To that extent, NP is a very important concept for the future of HM research.
| Author | : Hai Yu Xu |
| Publisher | : Frontiers Media SA |
| Total Pages | : 1019 |
| Release | : 2023-09-19 |
| Genre | : Science |
| ISBN | : 2832535518 |
Download Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications Book in PDF, ePub and Kindle
ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
| Author | : Mariano Bizzarri |
| Publisher | : Springer Nature |
| Total Pages | : 493 |
| Release | : 2020-04-17 |
| Genre | : Medical |
| ISBN | : 3030328570 |
Download Approaching Complex Diseases Book in PDF, ePub and Kindle
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
| Author | : Aiping Lu |
| Publisher | : Frontiers Media SA |
| Total Pages | : 264 |
| Release | : 2021-06-23 |
| Genre | : Science |
| ISBN | : 2889668851 |
Download Systems Pharmacology and Traditional Chinese Medicine Book in PDF, ePub and Kindle
| Author | : Weici Tang |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1005 |
| Release | : 2013-06-29 |
| Genre | : Medical |
| ISBN | : 3642737390 |
Download Chinese Drugs of Plant Origin Book in PDF, ePub and Kindle
Traditional Chinese medicine has been used for thousands of years by a large population. It is currently still serving many of the health needs of the Chinese people; and still enjoying their confi dence it is practised in China in parallel with modern Western medical treatment. In addition to scientific organisations dedi cated to modern Western medicine, e. g. the Chinese Academy of Medical Sciences and various medical schools, a series of parallel institutions have been established in China to promote traditional Chinese medicine, such as the Academy of Traditional Chinese Medicine and training institutions. Almost all hospitals in China have a department of traditional medicine. Furthermore, a large number of scientific journals are dedicated to traditional Chinese medicine, covering both experimental and clinical investigations. Medicinal materials constitute a key topic in the treatment of disease according to traditional Chinese medicine. The Chinese Pharmacopoeia (1985 edition) is therefore divided into two sepa rate volumes, Volume I containing traditional Chinese medicinal materials and preparations and Volume II containing pharmaceu tics of Western medicine. The oldest Chinese review of medicinal materials, Shennong Bencao Jing (100-200 A. D. ), covered 365 herbal drugs. The clas sic compilation in this field, Bencao Gangmu (Compendium of Materia Medica), was published in 1578 by Li Shi-zhen and recorded as many as 1898 crude drugs of plant, animal and min eral origin.
