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Natural Products in Clinical Trials

Natural Products in Clinical Trials
Author: Atta-ur- Rahman
Publisher: Bentham Science Publishers
Total Pages: 253
Release: 2018-03-03
Genre: Medical
ISBN: 1681082136
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Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Natural Products in Clinical Trials: Volume 2

Natural Products in Clinical Trials: Volume 2
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Total Pages: 280
Release: 2020-08-20
Genre: Medical
ISBN: 9811425752
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Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives. This book series presents reviews of exciting new bioactive natural products that have huge potential as drugs. Each volume presents comprehensive chapters contributed by eminent scientists. The volumes focus on drug candidates which are in the later stages of drug development and are being evaluated in clinical trials. The series, therefore, highlights the importance of natural products in our lives. The second volume covers the following topics: - A review of recent patents and natural products in clinical trials to treat schistosomiasis - Natural products: the new intervention regimen for metabolic disorders - Fluorine-containing drugs and drug candidates derived from natural products - Natural products for the management of cardiovascular diseases - Implication of natural compounds for the prevention of ocular diseases.

Clinical Trials

Clinical Trials
Author: Tom Brody
Publisher: Academic Press
Total Pages: 897
Release: 2016-02-19
Genre: Medical
ISBN: 0128042583
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Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more Extensively covers the "study schema" and related features of study design Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers

Natural Products as Source of Molecules with Therapeutic Potential

Natural Products as Source of Molecules with Therapeutic Potential
Author: Valdir Cechinel Filho
Publisher: Springer
Total Pages: 531
Release: 2018-12-07
Genre: Science
ISBN: 3030005453
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This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Natural Products in Clinical Trials Volume

Natural Products in Clinical Trials Volume
Author: Atta-ur Rahman
Publisher:
Total Pages:
Release: 2018-03-02
Genre:
ISBN: 9781681082141
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Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume presents comprehensive reviews in cutting edge fields contributed by eminent scientists. The first volume covers the following topics: bioactive compounds from marine invertebrates natural product derived drugs for immunological and inflammatory diseases clinical trials of curcumin, camptothecin, astaxanthin, and biochanin antibacterial and antifungal drugs from natural sources natural products as anti-HIV medicines

Drug Discovery and Development

Drug Discovery and Development
Author: Ramarao Poduri
Publisher: Springer Nature
Total Pages: 522
Release: 2021-02-15
Genre: Medical
ISBN: 9811555346
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This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Natural Product Chemistry for Drug Discovery

Natural Product Chemistry for Drug Discovery
Author: Antony D. Buss
Publisher: Royal Society of Chemistry
Total Pages: 459
Release: 2010
Genre: Medical
ISBN: 0854041931
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This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

WHO Global Report on Traditional and Complementary Medicine 2019

WHO Global Report on Traditional and Complementary Medicine 2019
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 228
Release: 2019-05-16
Genre: Business & Economics
ISBN: 9241515430
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This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).

Natural Medicines

Natural Medicines
Author: Dilip Ghosh
Publisher: CRC Press
Total Pages: 632
Release: 2019-07-18
Genre: Medical
ISBN: 1351741357
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Globally, natural medicine has been considered as an important alternative to modern allopathic medicine. Although natural medicines are popular in society, only limited medicinal herbs have been scientifically evaluated for their potential in medical treatment. This book connects various aspects of the complex journey from traditional medicine to modern medicine. It provides information on topics including global regulations and regulatory hurdles, diverse nutritional challenges and potential health benefits, novel food innovations especially seed-to-clinic approaches, and future trends. FEATURES • Provides information on sustainable use of natural products in the development of new drugs and clinically validated herbal remedies • Discusses issues on evaluation and clinical aspects of herbal medicine, promotion and development, safety evaluation, metabolite profiling, biomarker analysis, formulation, and stability testing • Describes traditional uses of natural medicine through identification, isolation and structural characterization of their active components • Elucidates mechanisms of biological action, adverse effects and identification of their molecular targets of natural medicine • Multidisciplinary appeal including chemistry, pharmacology, pharmacognosy and cell and molecular biology, as well as integration with clinical medicine This book serves as an essential guide for individuals researching natural medicines, and industry employees in areas including drug development, pharmacology, natural products chemistry, clinical efficacy, ethnopharmacology, pharmacognosy, phytotherapy, phyto-technology and herbal science.