Nanoscale And Microscale Approaches For Engineering The In Vitro Cellular Microenvironment PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Nanoscale And Microscale Approaches For Engineering The In Vitro Cellular Microenvironment PDF full book. Access full book title Nanoscale And Microscale Approaches For Engineering The In Vitro Cellular Microenvironment.
Author | : Ali Khademhosseini |
Publisher | : |
Total Pages | : 364 |
Release | : 2005 |
Genre | : |
ISBN | : |
Download Nanoscale and Microscale Approaches for Engineering the in Vitro Cellular Microenvironment Book in PDF, ePub and Kindle
(cont.) To easily immobilize cells within channels, poly(ethylene glycol) microstructures were used to capture cells within low shear stress regions. These techniques also allowed for the fabrication of multiphenotype cell arrays. In addition, techniques were developed to control the interaction of cells within hydrogels by controlling the spatial properties of hydrogels.
Author | : Ali Khademhosseini |
Publisher | : Artech House |
Total Pages | : 647 |
Release | : 2008 |
Genre | : Science |
ISBN | : 1596931493 |
Download Micro and Nanoengineering of the Cell Microenvironment Book in PDF, ePub and Kindle
Supported with 140 illustrations, the volume exhaustively covers the micro- and nano-system technologies involved in developing cell-based bioengineering applications. You get full details on efforts to engineer the soluble and insoluble cell microenvironments, including the latest advances in microfluidic devices, surface patterning, 3D scaffolds, and techniques for engineering cellular mechanical properties and topography.
Author | : Ankur Singh |
Publisher | : Springer |
Total Pages | : 329 |
Release | : 2015-08-19 |
Genre | : Technology & Engineering |
ISBN | : 3319207261 |
Download Microscale Technologies for Cell Engineering Book in PDF, ePub and Kindle
This book offers readers cutting-edge research at the interface of polymer science and engineering, biomedical engineering, materials science, and biology. State-of-the-art developments in microscale technologies for cell engineering applications are covered, including technologies relevant to both pluripotent and adult stem cells, the immune system, and somatic cells of the animal and human origin. This book bridges the gap in the understanding of engineering biology at multiple length scale, including microenvironmental control, bioprocessing, and tissue engineering in the areas of cardiac, cartilage, skeletal, and vascular tissues, among others. This book also discusses unique, emerging areas of micropatterning and three-dimensional printing models of cellular engineering, and contributes to the better understanding of the role of biophysical factors in determining the cell fate. Microscale Technologies for Cell Engineering is valuable for bioengineers, biomaterial scientists, tissue engineers, clinicians, immunoengineers, immunologists and stem cell biologists, as it offers a review of the current cutting-edge cell engineering research at multiple length scale and will be valuable in developing new strategies for efficient scale-up and clinical translation.
Author | : |
Publisher | : |
Total Pages | : 846 |
Release | : 2006 |
Genre | : Dissertations, Academic |
ISBN | : |
Download Dissertation Abstracts International Book in PDF, ePub and Kindle
Author | : Mary Christin Regier |
Publisher | : |
Total Pages | : 0 |
Release | : 2016 |
Genre | : |
ISBN | : |
Download New Approaches for Investigating Cellular Responses in [in Vitro] Microenvironments Book in PDF, ePub and Kindle
Cell-microenvironment interactions are essential to tissue and organ functions and to overall health, but studying these dynamic and bidirectional relationships in vivo is typically not practical or results are difficult to interpret. in vitro models with improved accessibility, increased tractability, and more numerous available readouts have been widely utilized and promise to continue to provide valuable insights into regulation between cells and their microenvironments. However, there remain aspects of in vitro model interrogation and design that are suboptimal. This document presents new approaches for connecting cells to their location at a sub-model level, for investigating the effects of model parameters on populations, and for generating a model with a desired global structure. Thereby the work presented here has implications for the way in vitro models are used and designed on three levels of model structure. First, though there exists heterogeneity in cells and in microenvironments and though these differences influence each other, existing techniques limitedly enable characterization of cells while maintaining contextual information. The method in Chapter 2 allows one to impart position dependent signals to cells on a substrate in a straightforward and customizable fashion. The method will be applicable in tracking cells before and after dissociation as well as in defining soluble factor patterning. Second, in vitro models are increasingly complex, however there is little systematic knowledge concerning how complexity affects cellular behaviors and model function. Chapters 3 and 4 describe effects of 3D matrix composition and heterotypic complexity. These studies use models that allow single parameter changes to dissect the impact of a variable. Integration of these results with other similarly systematic studies with implementation of data analysis techniques has the potential to guide model design and demonstrate fundamental aspects of cell-microenvironment interactions. Finally, in chapter 5 design considerations for a microscale in vitro model that recreates many structural and functional attributes of in vivo skin are presented. Modes of failure associated with translation to the microscale as well as solutions that invoke physical phenomena at the microscale are discussed. The model itself and the design features implemented promise to be useful tools moving forward.
Author | : M. H. Fulekar |
Publisher | : I. K. International Pvt Ltd |
Total Pages | : 296 |
Release | : 2010 |
Genre | : Technology & Engineering |
ISBN | : 9380026986 |
Download Nanotechnology Book in PDF, ePub and Kindle
Highlights the latest developments and advances in the field of nanoscience and nanotechnology and their applications in the design and development of material science and devices, energy, drug delivery, cosmetics, biology, biotechnology, tissue engineering, bioinformatics, information technology, agriculture and food, environmental protection, health risk, ethics, and regulations.
Author | : Daniel Gallego-Perez |
Publisher | : |
Total Pages | : 229 |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Micro/nanoscale Engineering of the Cell Microenvironment Book in PDF, ePub and Kindle
Abstract: The cellular microenvironment/niche plays a significant role in the regulation of a host of physiological and pathophysiological processes. Autonomous signals derived from the intrinsic cell machinery can be inhibited or potentiated by soluble or insoluble factors present in such niche in the form of chemical, structural, and topographical cues. Similarly, specific cell behaviors can be evoked by the same factors even in the absence of intracellular inputs. A normal or aberrant interplay between the cells and their niche could determine for example either the continuation of a regular biological process, or the onset of a disease. Consequently, a better understanding of the mechanisms underlying these cell-microenvironment interactions could help to develop novel therapies for a number of conditions.
Author | : M. Ann Garrison Darrin |
Publisher | : CRC Press |
Total Pages | : 592 |
Release | : 2016-04-19 |
Genre | : Technology & Engineering |
ISBN | : 143983735X |
Download Systems Engineering for Microscale and Nanoscale Technologies Book in PDF, ePub and Kindle
To realize the full potential of micro- and nanoscale devices in system building, it is critical to develop systems engineering methodologies that successfully integrate stand-alone, small-scale technologies that can effectively interface with the macro world. So how do we accomplish this?Systems Engineering for Microscale and Nanoscale Technologie
Author | : Shaun Patrick Garland |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : |
ISBN | : 9781321362541 |
Download Advancing the Paradigm of in Vitro Tissue Culture Book in PDF, ePub and Kindle
Despite being over 100 years old, tissue culture has not fundamentally changed in the past 50 years. There is an expanding body of work indicating that the cellular microenvironment is critical for maintaining homeostasis and function. Of particular interest are the ubiquitous biophysical cues in the extracellular matrix (ECM) that communicate bi-directionally, as these cues regulate cellular behavior which in turn regulates matrix turnover and composition. Dysregulation of the ECM has been implicated in many chronic diseases. Chronic diseases are also typically characterized by continuous, low levels of oxidative stress that significantly affects both cellular processes and the ECM by the damaging chemical substitutions of proteins and DNA through the action of free radicals. Although the importance of matrix-cell interactions are becoming better understood, many studies that investigate disease mechanisms still grow cells on stiff, featureless substrates and expose them to non-physiological concentration profiles of oxidants. Part of the reason for the slow adoption of newer culture environments is due to the poor availability, difficulty of use, and inability to fine tune current techniques. In this work, two novel in vitro engineering solutions that address these issues are described for the fabrication of physiologically soft ECM-like nanopatterned substrates and the development of a continuous oxidative stress system.
Author | : David E. Reisner |
Publisher | : CRC Press |
Total Pages | : 587 |
Release | : 2011-08-25 |
Genre | : Medical |
ISBN | : 143980463X |
Download Bionanotechnology II Book in PDF, ePub and Kindle
The impact and importance of nanotechnology continues to grow, and nanomedicine and biotechnology have become areas of increased development. Biomedical engineers who work with biological processes and structures must have a deeply rooted understanding of the role of bionanotechnology, a rapidly evolving sector of the nanotechnology field. Bionanotechnology II: Global Prospects, a follow-up to the editor’s highly successful first volume, contains 26 entirely new contributions that provide a broad survey of research shaping this critical field. With coverage of technical and nontechnical areas, the book offers representative reporting on a wide variety of activity from around the world. It discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nanobiomaterials. Topics discussed include: Emerging microscale technologies Bionanotech-based water treatment Tissue engineering and drug delivery Antimicrobial nanomaterials in the textile industry Bionanotechnology applications in plants and agriculture With contributions from researchers in Israel, Egypt, Iran, Jordan, Singapore, South Africa, Turkey, Thailand, Argentina, the United Kingdom, and the United States, this volume presents a worldwide perspective on some of the critical areas shaping bionanotechnology today.