Nanoparticle Enhanced Radiotherapy PDF Download
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| Author | : Erno Sajo |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020 |
| Genre | : Cancer |
| ISBN | : 9780750323963 |
Download Nanoparticle Enhanced Radiation Therapy Book in PDF, ePub and Kindle
"Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose in Nanoparticle-Enhanced Radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target and control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Part of IOP Series in Global Health and Radiation Oncology." -- Prové de l'editor.
| Author | : Reem Hussain Ali Ahmad |
| Publisher | : |
| Total Pages | : |
| Release | : 2019 |
| Genre | : |
| ISBN | : |
Download Nanoparticle Enhanced Radiotherapy Book in PDF, ePub and Kindle
| Author | : Erno Sajo |
| Publisher | : Myprint |
| Total Pages | : 322 |
| Release | : 2020-11-19 |
| Genre | : |
| ISBN | : 9780750323970 |
Download Nanoparticle Enhanced Radiation Therapy Book in PDF, ePub and Kindle
Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose of nanoparticle-enhanced radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target as well as control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Key Features Covers the most important advances in nanoparticle-aided radiation therapy over the last few decades Features contributions from leaders in the field Focuses first on the fundamentals of radiosensitization, then it continues with imaging methods and concludes with various clinical applications
| Author | : Erno Prof. Sajo |
| Publisher | : Iop Expanding Physics |
| Total Pages | : 350 |
| Release | : 2020-11-12 |
| Genre | : Medical |
| ISBN | : 9780750323949 |
Download Nanoparticle-Aided Radiotherapy Book in PDF, ePub and Kindle
Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose of nanoparticle-enhanced radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target as well as control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Key Features Covers the most important advances in nanoparticle-aided radiation therapy over the last few decades Features contributions from leaders in the field Focuses first on the fundamentals of radiosensitization, then it continues with imaging methods and concludes with various clinical applications
| Author | : Simon Vallières |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : |
Download Dose Enhancement with Nanoparticles in Radiotherapy Using Gold-doxorubicin Conjugates Book in PDF, ePub and Kindle
"Gold nanoparticles have recently been demonstrated to show properties in increasing energy deposition in tissues upon irradiation by X-rays. The present study uses gold nanoparticles conjugated with doxorubicin, a chemotherapeutic agent. The project acts on two simultaneous fronts, namely with chemotherapy and nanoparticle-enhanced radiotherapy treatments. The aim is to test the effectiveness of gold-doxorubicin conjugates in a radiochemotherapy context for the treatment of murine melanoma tumours. B16-F10 melanoma cells are grafted subcutaneously on the flank of male wild black mice. Intratumoural injections of gold-doxorubicin conjugates are given, followed by a single dose of X-rays. The effectiveness of the treatment is compared to the control groups and dose enhancement is quantified. Tumour growth inhibition was observed for at least six days postirradiation, as well as an enhanced radiobiological effect of gold nanoparticles. However, gold-doxorubicin conjugates were not as cytotoxic as expected. A small animal irradiator was calibrated following the AAPM TG-61 protocol. Dose uncertainties to tumours were assessed by developing a Monte Carlo model of the source using EGSnrc (National Research Council of Canada). Monte Carlo simulations of the 3D dose distributions in tumours were also calculated. Excellent agreement was observed between the source model and experimental measurements, the effective energy of the beam reported by the model showed a 3% difference with the measured value, and less than 1% when compared to the one based on SpekCalc, a semi-empirical spectra calculation tool. Moreover, a standard deviation of 60% on the tumour volume distribution translated into 5% of median dose variation in a mice cohort, which is relatively low. This project lies in the use of a stable gold-doxorubicin conjugate in a combined treatment using both chemotherapy and radiotherapy. This allows to reduce the radiation dose given to healthy tissues while maintaining the same tumour control." --
| Author | : Caitlin Latimer |
| Publisher | : |
| Total Pages | : |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
Download Octaarginine Labelled 30 Nm Gold Nanoparticles as Agents for Enhanced Radiotherapy Book in PDF, ePub and Kindle
| Author | : Jonas Albers |
| Publisher | : |
| Total Pages | : |
| Release | : 2021 |
| Genre | : |
| ISBN | : |
Download Preclinical Evaluation of Nanoparticle Enhanced Breast Cancer Diagnosis and Radiation Therapy Book in PDF, ePub and Kindle
Triple negative breast cancer (TNBC) is an aggressive type of cancer which makes up 15-20% of all newly diagnosed cases, lacking the main target molecules for tumor specific treatment. Surgery or systemic therapy by chemotherapy are frequently used in the clinic and combined with radiation therapy to improve locoregional control in breast cancer patients after surgery. With a poor prognosis, there is a clear need to explore new treatment options for TNBC. The aim of the here presented PhD project was to evaluate the feasibility to enhance the biological effect of radiation therapy and incre...
| Author | : Hala Gali-Muhtasib |
| Publisher | : CRC Press |
| Total Pages | : 179 |
| Release | : 2020-02-19 |
| Genre | : Medical |
| ISBN | : 1000681416 |
Download Nanoparticle Drug Delivery Systems for Cancer Treatment Book in PDF, ePub and Kindle
In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
| Author | : Zane Barak Starkewolfe |
| Publisher | : |
| Total Pages | : |
| Release | : 2014 |
| Genre | : |
| ISBN | : 9781321023121 |
Download Novel Approaches for Cancer Therapy Book in PDF, ePub and Kindle
This work explores the interaction of X-rays with nanomaterials and examines applications of this interaction for the treatment of cancer. The absorption of X-rays by nanomaterials and the mechanism by which these structures induce the production of radicals is studied. Using nanoparticles of various materials and sizes, we elucidate a mechanism of the interactions between the nanoparticles and the X-ray radiation-generated radical species. We measured the enhanced generation of radicals by nanomaterials irradiated with X-ray-radiation and termed this Nanoparticle Enhanced X-ray Therapy (NEXT). Using this approach we measure an increase in cell death employing various sizes and types of nanoparticles under X-ray radiation. While the enhancement of this cell death has a promising application potential for cancer therapy, the overall benefit will be determined by the overall X-ray absorption and the number of generated radical species. Utilizing the mechanism for radical generation by nanomaterials under X-ray radiation, we devised a novel approach for X-ray Enabled Nanochemistry (XEN) that allows for chemical reactions to take place only on the surface of nanomaterials. These location specific reactions are induced and enhanced by X-ray radiation. Using an approach called X-ray Triggered Chemotherapy (XTC), cancer drug molecules were attached to the oligonucleotide strands bound to the surface of gold nanoparticles and the applications of these nanoparticle drug carriers is explored for the treatment of cancer. In breast cancer cells, we observed an increase in cancer cell death using the XTC approach as compared with the use of either X-ray radiation or chemotherapy alone. We find that nanomaterials can enhance the efficacy of X-rays in cancer treatment and that nanomaterials under X-ray radiation can be used for the remote activation of otherwise dormant cancer drugs at the tumor site.
| Author | : Arshi Malik |
| Publisher | : Springer Nature |
| Total Pages | : 249 |
| Release | : 2021-08-01 |
| Genre | : Medical |
| ISBN | : 9811575649 |
Download Nanomedicine for Cancer Diagnosis and Therapy Book in PDF, ePub and Kindle
This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.
