Myocardial Ischemia Mechanisms Reperfusion Protection PDF Download
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| Author | : Morris Karmazyn |
| Publisher | : Birkhäuser |
| Total Pages | : 508 |
| Release | : 2013-03-12 |
| Genre | : Medical |
| ISBN | : 3034889887 |
Download Myocardial Ischemia: Mechanisms, Reperfusion, Protection Book in PDF, ePub and Kindle
Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
| Author | : Bohuslav Ost'ádal |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 198 |
| Release | : 2013-03-09 |
| Genre | : Medical |
| ISBN | : 147573025X |
Download Cardiac Ischemia: From Injury to Protection Book in PDF, ePub and Kindle
Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
| Author | : Robert Fitridge |
| Publisher | : University of Adelaide Press |
| Total Pages | : 589 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1922064009 |
Download Mechanisms of Vascular Disease Book in PDF, ePub and Kindle
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
| Author | : Naranjan S. Dhalla |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 564 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461503558 |
Download Myocardial Ischemia and Preconditioning Book in PDF, ePub and Kindle
Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.
| Author | : Derek Hausenloy |
| Publisher | : Oxford University Press |
| Total Pages | : 138 |
| Release | : 2009-08-20 |
| Genre | : Medical |
| ISBN | : 019954476X |
Download Cardioprotection Book in PDF, ePub and Kindle
Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.
| Author | : Tomas A. Salerno |
| Publisher | : John Wiley & Sons |
| Total Pages | : 344 |
| Release | : 2008-04-15 |
| Genre | : Medical |
| ISBN | : 1405178434 |
Download Myocardial Protection Book in PDF, ePub and Kindle
Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
| Author | : Derek M. Yellon |
| Publisher | : |
| Total Pages | : 232 |
| Release | : 1992 |
| Genre | : Medical |
| ISBN | : |
Download Myocardial Protection Book in PDF, ePub and Kindle
An insight into the theories and controversies regarding myocardial reperfusion and reperfusion-induced injury. The ideas presented advance the understanding of the relationship of reperfusion injury to the beneficial effects of restoring coronary flow to the myocardium after an ischemic insult.
| Author | : Joel P. French |
| Publisher | : |
| Total Pages | : 82 |
| Release | : 2006 |
| Genre | : |
| ISBN | : |
Download Mechanisms of Protection Against Myocardial Ischemia-reperfusion Injury Book in PDF, ePub and Kindle
Exercise appears to provide protection against these events by over-expressing MnSOD, which attenuates IR-induced Ca2+-handling protein oxidation, calpain activation and Ca2+-handling protein degradation.
| Author | : Juan Carlos Kaski |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 311 |
| Release | : 2012-07-20 |
| Genre | : Medical |
| ISBN | : 1849960194 |
Download Management of Myocardial Reperfusion Injury Book in PDF, ePub and Kindle
Much has been written about reperfusion injury in the past decade but unfortunately the information has been generally presented in the form of original specialist papers and little if any integral publication exists on the topic, summarising and analysing the clinical impact of the condition and its management. The pathophysiology and molecular mechanisms of reperfusion injury are complex and, regarding diagnosis, individual diagnostic techniques have been proposed but without a proper assessment of the relative values of these methods. A publication dealing with integral diagnostic strategies would be welcome by the managing physician. Management of the condition is also problematic, as strategies that appear to work in the experimental models do not translate into beneficial interventions in patients. There is a need for these issues to be addressed and discussed in a monographic fashion. Management of Myocardial Reperfusion Injury will tackle these issues in a modern and systematic way and the information will be delivered in a fashion that will be appealing to the reader.
| Author | : Seibu Mochizuki |
| Publisher | : Springer |
| Total Pages | : 601 |
| Release | : 2007-11-23 |
| Genre | : Medical |
| ISBN | : 0585398445 |
Download The Ischemic Heart Book in PDF, ePub and Kindle
Over the past three decades, impressive progress in the field of pathogenesis, prevention and therapy of ischemic heart disease has resulted in a marked decline in mortality in the Western World. However, the incidence of this devastating disease is on the rise in developing countries. The Ischemic Heart is based upon a recent symposium in Tokyo on the subject. This volume is organized into two sections: (i) Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury and (ii) Preconditioning and Protection of Ischemia-Reperfusion Injury, and contains up-to-date information concerning the current concepts of ischemia-reperfusion injury, the sequence of events resulting in the loss of contractile dysfunction, and mechanisms of cardioprotection by several drugs as well as the role of ischemic preconditioning in attenuating problems associated with ischemia-reperfusion injury.
