Multivariate Biomarker Discovery PDF Download
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Author | : Darius M. Dziuda |
Publisher | : Cambridge University Press |
Total Pages | : 295 |
Release | : 2024-04-30 |
Genre | : Science |
ISBN | : 100900770X |
Download Multivariate Biomarker Discovery Book in PDF, ePub and Kindle
Multivariate biomarker discovery is increasingly important in the realm of biomedical research, and is poised to become a crucial facet of personalized medicine. This will prompt the demand for a myriad of novel biomarkers representing distinct 'omic' biosignatures, allowing selection and tailoring treatments to the various individual characteristics of a particular patient. This concise and self-contained book covers all aspects of predictive modeling for biomarker discovery based on high-dimensional data, as well as modern data science methods for identification of parsimonious and robust multivariate biomarkers for medical diagnosis, prognosis, and personalized medicine. It provides a detailed description of state-of-the-art methods for parallel multivariate feature selection and supervised learning algorithms for regression and classification, as well as methods for proper validation of multivariate biomarkers and predictive models implementing them. This is an invaluable resource for scientists and students interested in bioinformatics, data science, and related areas.
Author | : Haleem J. Issaq |
Publisher | : Academic Press |
Total Pages | : 489 |
Release | : 2013-05-20 |
Genre | : Science |
ISBN | : 0123947952 |
Download Proteomic and Metabolomic Approaches to Biomarker Discovery Book in PDF, ePub and Kindle
Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research Includes techniques from a range of biomarker discoveries Covers all steps involved in biomarker discovery, from study design to study execution
Author | : Sanjeeva Srivastava |
Publisher | : Springer |
Total Pages | : 120 |
Release | : 2016-09-30 |
Genre | : Medical |
ISBN | : 8132228375 |
Download Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges Book in PDF, ePub and Kindle
This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With the need for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of “social innovation” to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and prominence recently due to their immense potential in clinical and pharmaceutical innovation literatures. The broader goal post-biomarker discovery is to translate their use in clinics. However, the road from bench-to-bed side is arduous and complex that is subject to oversight from various national and international regulatory bodies. Chapter 8 underscores these regulatory science considerations and provides a concise overview on intellectual property rights in biomarker discovery. Thus, this book contributed by eminent biomarker scientists, clinicians, translational researchers and social scientists holistically covers the various facets of the biomarker discovery journey from “cell to society” in developing world. The lessons learned and highlighted here are of interest to the life sciences community in a global and interdependent world.
Author | : Mikkel West-Nørager |
Publisher | : |
Total Pages | : |
Release | : 2009 |
Genre | : |
ISBN | : |
Download Development of Multivariate Analytic Methods for Discovery of Novel Serum Biomarkers in Ovarian Cancer Book in PDF, ePub and Kindle
Author | : Darius M. Dziuda |
Publisher | : John Wiley & Sons |
Total Pages | : 348 |
Release | : 2010-07-16 |
Genre | : Computers |
ISBN | : 0470593407 |
Download Data Mining for Genomics and Proteomics Book in PDF, ePub and Kindle
Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.
Author | : Mahmoud H. Hamdan |
Publisher | : Wiley-Interscience |
Total Pages | : 0 |
Release | : 2007-02-09 |
Genre | : Science |
ISBN | : 9780471745167 |
Download Cancer Biomarkers Book in PDF, ePub and Kindle
Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: * Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies * Includes a detailed discussion of protein networks and protein phosphorylation in cancer * Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics * Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies * Discusses related regulatory and ethical issues With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.
Author | : Nusrat Rabbee |
Publisher | : CRC Press |
Total Pages | : 168 |
Release | : 2020-03-11 |
Genre | : Mathematics |
ISBN | : 0429766793 |
Download Biomarker Analysis in Clinical Trials with R Book in PDF, ePub and Kindle
The world is awash in data. This volume of data will continue to increase. In the pharmaceutical industry, much of this data explosion has happened around biomarker data. Great statisticians are needed to derive understanding from these data. This book will guide you as you begin the journey into communicating, understanding and synthesizing biomarker data. -From the Foreword, Jared Christensen, Vice President, Biostatistics Early Clinical Development, Pfizer, Inc. Biomarker Analysis in Clinical Trials with R offers practical guidance to statisticians in the pharmaceutical industry on how to incorporate biomarker data analysis in clinical trial studies. The book discusses the appropriate statistical methods for evaluating pharmacodynamic, predictive and surrogate biomarkers for delivering increased value in the drug development process. The topic of combining multiple biomarkers to predict drug response using machine learning is covered. Featuring copious reproducible code and examples in R, the book helps students, researchers and biostatisticians get started in tackling the hard problems of designing and analyzing trials with biomarkers. Features: Analysis of pharmacodynamic biomarkers for lending evidence target modulation. Design and analysis of trials with a predictive biomarker. Framework for analyzing surrogate biomarkers. Methods for combining multiple biomarkers to predict treatment response. Offers a biomarker statistical analysis plan. R code, data and models are given for each part: including regression models for survival and longitudinal data, as well as statistical learning models, such as graphical models and penalized regression models.
Author | : Mitchell H. Katz |
Publisher | : Cambridge University Press |
Total Pages | : 228 |
Release | : 2006-02-09 |
Genre | : Medical |
ISBN | : 9780521549851 |
Download Multivariable Analysis Book in PDF, ePub and Kindle
How to perform and interpret multivariable analysis, using plain language rather than complex derivations.
Author | : Fengqing (Zoe) Zhang |
Publisher | : |
Total Pages | : 142 |
Release | : 2010 |
Genre | : Biochemical markers |
ISBN | : |
Download Multivariate Analysis Methods for IMS Data Biomarker Selection and Classification Book in PDF, ePub and Kindle
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 335 |
Release | : 2010-06-25 |
Genre | : Medical |
ISBN | : 0309157277 |
Download Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease Book in PDF, ePub and Kindle
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.