Mood And Anxiety Related Phenotypes In Mice PDF Download
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| Author | : Todd D Gould |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2009-10-29 |
| Genre | : Medical |
| ISBN | : 9781607613022 |
Download Mood and Anxiety Related Phenotypes in Mice Book in PDF, ePub and Kindle
Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful NeuromethodsTM series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.
| Author | : Todd D Gould |
| Publisher | : Humana Press |
| Total Pages | : 382 |
| Release | : 2011-09-02 |
| Genre | : Medical |
| ISBN | : 9781617793127 |
Download Mood and Anxiety Related Phenotypes in Mice Book in PDF, ePub and Kindle
Preclinical research related to mood and anxiety disorders relies extensively upon mouse behavioral tests and models, the use of which continues to increase as a greater number of underlying susceptibility genes are discovered, new targets for medications are identified, and clinical studies reveal novel neurobiological risk factors. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II serves as a complement to the previous volume in order to offer a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications. As a collection presented in the Neuromethods series, each chapter provides a brief background and review of the test or model as well as a complete and up-to-date protocol narrative. Authoritative and comprehensive, Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II is an ideal resource for scientists actively pursuing or interested in establishing vital behavioral protocols in their laboratories.
| Author | : |
| Publisher | : |
| Total Pages | : 398 |
| Release | : 2011-09-03 |
| Genre | : |
| ISBN | : 9781617793141 |
Download Mood and Anxiety Related Phenotypes in Mice Book in PDF, ePub and Kindle
| Author | : Jaanus Harro |
| Publisher | : Springer Nature |
| Total Pages | : 404 |
| Release | : 2022-09-30 |
| Genre | : Medical |
| ISBN | : 1071627481 |
Download Psychiatric Vulnerability, Mood, and Anxiety Disorders Book in PDF, ePub and Kindle
This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and foster precision medicine. Chapters in this book cover topics such as how the sucrose preference succeeds or fails as a measurement of anhedonia; fear conditioning in laboratory rodents; animal models for mania; rodent models for studying the impact of variation in early life mother-infant interactions on mood and anxiety; and prediction of susceptibility/resilience toward animal models of PTSD. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, accommodating the novel views on how the neurobiology of psychiatric disorders should be reconceptualized, Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats is a valuable resource for all researchers interested in learning more about this important and developing field.
| Author | : Jerry J. Buccafusco |
| Publisher | : CRC Press |
| Total Pages | : 341 |
| Release | : 2000-08-29 |
| Genre | : Medical |
| ISBN | : 1420041819 |
Download Methods of Behavior Analysis in Neuroscience Book in PDF, ePub and Kindle
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 137 |
| Release | : 2008-04-10 |
| Genre | : Science |
| ISBN | : 0309108179 |
Download Recognition and Alleviation of Distress in Laboratory Animals Book in PDF, ePub and Kindle
Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.
| Author | : J.F. Cryan |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 283 |
| Release | : 2010-11-17 |
| Genre | : Medical |
| ISBN | : 3805596065 |
Download Depression: From Psychopathology to Pharmacotherapy Book in PDF, ePub and Kindle
Despite the availability of antidepressants for over 40 years, a substantial proportion of depressed patients do not respond adequately to treatment. Failure to respond effectively to treatment contributes to physical ill-health and psychiatric morbidity, often resulting in premature death of the depressed patient. The purpose of this volume is to consider the possible reasons for the limitations of the currently available antidepressants, to examine the advances in our understanding of the psychopathology of depression and how such knowledge may assist in the discovery of new methods of treatment. Leading international experts in this field discuss the possible underlying reasons for depression and limitations of current antidepressants. Opportunities for novel therapeutic approaches to dysfunctional circadian rhythms and mood disorders as well as current status and future perspectives for optimizing antidepressant management of depression are reviewed. This publication illustrates the breadth of the latest research and is valuable reading for psychiatrists, neuroscientists and pharmacologists.
| Author | : Wim E. Crusio |
| Publisher | : Cambridge University Press |
| Total Pages | : 361 |
| Release | : 2013-04-25 |
| Genre | : Science |
| ISBN | : 1107355575 |
Download Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes Book in PDF, ePub and Kindle
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
| Author | : Yogesh Dwivedi |
| Publisher | : CRC Press |
| Total Pages | : 485 |
| Release | : 2012-06-25 |
| Genre | : Medical |
| ISBN | : 143983881X |
Download The Neurobiological Basis of Suicide Book in PDF, ePub and Kindle
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 352 |
| Release | : 2004-12-11 |
| Genre | : Medical |
| ISBN | : 9780080522463 |
Download Human Brain Proteome Book in PDF, ePub and Kindle
Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic. * Describes the latest databases and techniques for analyzing the data generated by proteomics * Outlines the latest developments in proteomic methods * Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers
