Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer PDF Download
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| Author | : Loredana Cifaldi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 146 |
| Release | : 2020-07-31 |
| Genre | : |
| ISBN | : 2889638766 |
Download Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer Book in PDF, ePub and Kindle
In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
| Author | : Francisco Borrego |
| Publisher | : Frontiers Media SA |
| Total Pages | : 224 |
| Release | : 2016-09-08 |
| Genre | : Immunologic diseases. Allergy |
| ISBN | : 2889199347 |
Download NK Cell-Based Cancer Immunotherapy Book in PDF, ePub and Kindle
Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.
| Author | : Maite Alvarez Rodriguez |
| Publisher | : |
| Total Pages | : |
| Release | : 2012 |
| Genre | : |
| ISBN | : 9781267967367 |
Download Natural Killer Cells Book in PDF, ePub and Kindle
Natural killer (NK) cell-based immunotherapy has become a promising cancer therapy due to the ability of NK cells to eliminate tumor cells without prior sensitization. Therefore, multiple strategies to improve NK cell function and expansion are currently under investigation. However, several NK cell parameters still need to be elucidated. NK cell activation is highly regulated by the expression of inhibitory (ie., Ly49G2, Ly49A or NKG2A) and activating (ie., NKG2D) receptors that recognize major histocompatibility complex (MHC) class-I or MHC class-I-like molecules as well as the presence of stimulating (ie; interleukin-2 [IL-2] or IL-15) or suppressive (ie., transforming growth factor-beta [TGF-beta]) cytokines. We were interested in studying the recovery of NK cells after hematopoietic stem cell transplantation (HSCT) and if this recovery was affected by MHC class-I haplotype. We also wanted to determine if the administration of IL-2 in combination with TGF-beta neutralization with a monoclonal antibody (mAb) results in enhanced anti-tumor responses and accelerated NK cell reconstitution in resting and HSCT conditions. We observed a preferential expansion of Ly49G2+ NK cells early after HSCT, IL-2 stimulation, and virus infection independent of MHC class-I expression. Interestingly, the NK cell subset that also co-expresses NKG2A was preferentially expanded after stimulation with IL-2 and anti-TGF-beta as well. These data suggest that Ly49G2 and NKG2A behave as activation markers rather than inhibitory receptors early during stimulating conditions. IL-2 and anti-TGF-beta administration also resulted in increased tumor efficacy that was NK and CD8 T cell-dependent, supporting the potential use of this immunotherapeutic strategy in cancer treatment. Surprisingly, a regulation between NK and CD8 T cells in a non-antigen-specific stimulation model was also observed. Additionally, we demonstrated that the MHC class-I haplotype impacts the efficacy of mAbs against NK cell inhibitory receptors due to the formation of cis-interactions between MHC class-I and the inhibitory receptor illustrated here by H2d haplotype and Ly49A. In conclusion, this study illustrates the complexity of NK cells due to the duality observed in the inhibitory receptors Ly49G2 and NKG2A behavior depending of the stimulatory environment as well as their immunesuppressive role by controlling CD8 T cell responses in that environment. It is becoming more and more evident that NK cells are not a simplistic innate immune cell as they are typically described and may act as a bridge between both innate and adaptive immune systems.
| Author | : Jan B. Vermorken |
| Publisher | : Springer Nature |
| Total Pages | : 361 |
| Release | : 2023-03-27 |
| Genre | : Medical |
| ISBN | : 3031231759 |
Download Critical Issues in Head and Neck Oncology Book in PDF, ePub and Kindle
This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2016 |
| Genre | : |
| ISBN | : |
Download NK Cell-Based Cancer Immunotherapy Book in PDF, ePub and Kindle
Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.
| Author | : Tim F. Greten |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2018-08-22 |
| Genre | : Medical |
| ISBN | : 9783319879116 |
Download Immunotherapy of Hepatocellular Carcinoma Book in PDF, ePub and Kindle
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
| Author | : Federico Garrido |
| Publisher | : Springer |
| Total Pages | : 101 |
| Release | : 2019-05-28 |
| Genre | : Medical |
| ISBN | : 3030178641 |
Download MHC Class-I Loss and Cancer Immune Escape Book in PDF, ePub and Kindle
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”. Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast...ect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in “Tumor Immunology”.
| Author | : Michael T. Lotze |
| Publisher | : Academic Press |
| Total Pages | : 709 |
| Release | : 2009-11-12 |
| Genre | : Medical |
| ISBN | : 0080919294 |
Download Natural Killer Cells Book in PDF, ePub and Kindle
Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
| Author | : Srinivas S. Somanchi |
| Publisher | : Humana Press |
| Total Pages | : 365 |
| Release | : 2016-05-13 |
| Genre | : Medical |
| ISBN | : 9781493936823 |
Download Natural Killer Cells Book in PDF, ePub and Kindle
This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.
| Author | : John Masters |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 295 |
| Release | : 2006-04-11 |
| Genre | : Medical |
| ISBN | : 0306468727 |
Download Cancer Cell Lines Part 1 Book in PDF, ePub and Kindle
Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.
