Molecular Pathology Of Special Types Of Breast Cancer And Associated Lesions PDF Download

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Molecular Pathology of Breast Cancer

Molecular Pathology of Breast Cancer
Author: Sunil Badve
Publisher: Springer
Total Pages: 0
Release: 2016-12-16
Genre: Medical
ISBN: 9783319417592
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The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

Precision Molecular Pathology of Breast Cancer

Precision Molecular Pathology of Breast Cancer
Author: Ashraf Khan
Publisher: Springer
Total Pages: 336
Release: 2015-08-12
Genre: Medical
ISBN: 1493928864
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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Breast Pathology, E-Book

Breast Pathology, E-Book
Author: David J Dabbs
Publisher: Elsevier Health Sciences
Total Pages: 1008
Release: 2023-05-19
Genre: Medical
ISBN: 0323795234
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Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. Incorporates the latest classifications of breast pathology and molecular diagnosis. Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. Includes biomarker guideline updates throughout. Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.

Breast Pathology: Diagnosis and Insights, An Issue of Surgical Pathology Clinics

Breast Pathology: Diagnosis and Insights, An Issue of Surgical Pathology Clinics
Author: Stuart J. Schnitt
Publisher: Elsevier Health Sciences
Total Pages: 276
Release: 2012-10-02
Genre: Medical
ISBN: 1455739421
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Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular lesions of the breast; Combined epithelial-myoepithelial lesion; Immunhistochemical pitfalls in the diagnosis of breast lesions; Pathology considerations in patients treated with neoadjuvant chemotherapy; Molecular classification of breast cancer: Jorge Reis-Filho; Prognostic factors for patients with breast cancer: Traditional and New

Breast Pathology: Diagnosis and Insights, An Issue of Surgical Pathology Clinics

Breast Pathology: Diagnosis and Insights, An Issue of Surgical Pathology Clinics
Author: Stuart J. Schnitt
Publisher: Elsevier Health Sciences
Total Pages: 276
Release: 2012-09-28
Genre: Medical
ISBN: 1455743186
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Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular lesions of the breast; Combined epithelial-myoepithelial lesion; Immunhistochemical pitfalls in the diagnosis of breast lesions; Pathology considerations in patients treated with neoadjuvant chemotherapy; Molecular classification of breast cancer: Jorge Reis-Filho; Prognostic factors for patients with breast cancer: Traditional and New

Atlas of Differential Diagnosis in Breast Pathology

Atlas of Differential Diagnosis in Breast Pathology
Author: Puay Hoon Tan
Publisher: Springer
Total Pages: 638
Release: 2017-04-26
Genre: Medical
ISBN: 1493966979
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This atlas illustrates the range of breast lesions with detailed correlation of gross and microscopic features. Where relevant, radiological images are incorporated. A description of normal, developmental and physiological breast morphology will serve as introduction to the main content of this atlas. Classification of tumors is based on the latest World Health Organization Classification of Tumors of the Breast, 4th edition, 2012. As immunohistochemistry is a key adjunctive tool in the workup of breast lesions as well as used in prognostic evaluation of breast cancers, appropriate examples are interspersed among the lesions where pertinent.

Pathology and Epidemiology of Cancer

Pathology and Epidemiology of Cancer
Author: Massimo Loda
Publisher: Springer
Total Pages: 664
Release: 2016-09-01
Genre: Medical
ISBN: 3319351532
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This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored. Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.

Breast Pathology E-Book

Breast Pathology E-Book
Author: David J Dabbs
Publisher: Elsevier Health Sciences
Total Pages: 816
Release: 2011-12-20
Genre: Medical
ISBN: 1455737569
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Breast Pathology, edited by Dr. David J. Dabbs - leading expert in breast pathology and author of the best-selling reference Diagnostic Immunohistochemistry - presents an integrated and highly visual approach to breast pathology. This in-depth resource combines international perspectives and expertise on genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, immunohistochemistry, and theranostics so you can accurately diagnose the full spectrum of breast diseases. Stay current on hot topics in breast pathology, including theranostic aspects of diagnosis, genomic applications and molecular diagnosis, proper handling of breast specimens to ensure proper sampling and processing, and up-to-date immunohistochemical information. Get a clear picture of how diseases present from over 1750 high-quality images in full color. Tap into the expertise of leading authorities from around the world who offer an integrated approach, incorporating genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, and immunohistochemistry. Find information quickly and easily with the consistent format that features quick reference points at the beginning of each chapter.

Molecular Pathology and Diagnostics of Cancer

Molecular Pathology and Diagnostics of Cancer
Author: Domenico Coppola
Publisher: Springer Science & Business Media
Total Pages: 599
Release: 2013-11-29
Genre: Medical
ISBN: 9400771924
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Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.