Molecular Mechanisms Of Nociception Processing And Sensation In Drosophila Larvae PDF Download
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Author | : Melanie Rose Chin |
Publisher | : |
Total Pages | : 0 |
Release | : 2021 |
Genre | : Drosophila |
ISBN | : |
Download Molecular Mechanisms of Nociception Processing and Sensation in Drosophila Larvae Book in PDF, ePub and Kindle
In order to survive, an organism must be able to sense its surroundings. One particularly important sense is the processes of nociception, the ability to detect noxious stimuli. In Drosophila, when a noxious stimulus is sensed, larvae will perform a distinct rolling behavior. It is valuable to investigate the molecular mechanisms that give rise to the Drosophila larva's ability to sense noxious stimuli and to produce nociceptive rolling behavior as this will allow for a greater understanding of the nociceptive neural circuit and further insight into sensory perception. With the strong homology between Drosophila genes and human genes, these studies could find new targets for pain management. The initial focus of this dissertation was the gene defective proboscis extension response 11 (dpr11). dpr11 is a member of the immunoglobulin superfamily of proteins and it is part of a recently discovered protein network, the Dprome. It was my hypothesis that Dpr11 acts at synapses of nociceptor neurons to direct the formation of connections to downstream secondary neurons. While dpr11 was not found necessary for nociceptive behavior in Drosophila, gene expression studies supported the hypothesis that dpr11 and its binding partners DIP-gamma and DIP-beta are expressed in the nociception circuit. Importantly, dpr11-RNAi tests confirmed an off-target effect on another gene paralytic. Paralytic codes for the only voltage-gated sodium channel in Drosophila, and it is highly processed with many alternative transcripts. This study presents evidence that there are novel isoforms of para that may have a role in thermal nociception. This is a unique finding that relates to pain mechanisms in vertebrates as para is homologous to human voltage-gated sodium channels that are implicated in pain processing. This dissertation will also touch on TRP channels involved in sensory processing, including a mechanotransduction channel nompC and dTRPA1, the Drosophila homolog of human TRPA1. Data present a model for a novel role for nompC in the glia of the Drosophila larval brain, and information on the regulation of dTRPA1 in Drosophila nociceptive neurons. In summary, this dissertation broadly investigates the genetics behind neural circuit formation and sensory transduction processes, lending insight into how genes contribute to behavior and adding important information to the field of pain processing.
Author | : Fabien Marchand |
Publisher | : Frontiers Media SA |
Total Pages | : 207 |
Release | : 2022-10-17 |
Genre | : Science |
ISBN | : 2832502555 |
Download Molecular Mechanisms of Nociception Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 30 |
Release | : 2016 |
Genre | : Cold |
ISBN | : |
Download Reverse Genetic Screening of Innexin Gap Junction Proteins in Drosophila Neurons Book in PDF, ePub and Kindle
The reflexive response and perception of pain (nociception) is an evolutionarily conserved process in animals. Pain can be a major health concern and current treatments often prove insufficient, especially in regards to chronic pain. Greater understanding of the molecular processes underlying pain sensation could lead to new and more effective treatments. The aim of this study is to investigate the molecular mechanisms of cold nociception in Drosophila melanogaster. A specific subset of peripheral sensory neurons (Class III dendritic arborization (da) neurons), are implicated in Drosophila larvae's response to noxious cold. Previous literature has associated a family of gap junction protein, termed Innexins, to be responsible for various roles in the structure of the central nervous system and the giant fiber system in Drosophila. It is unknown if the Innexin family also functions in the Peripheral Nervous System (PNS). This study focused on Innexin family members as potential mediators of noxious cold-evoked sensory behavior within multidendritic neurons of the PNS. A cold behavioral assay was used to investigate the role of two innexin family member genes: ogre and shaking-B. The analyses revealed that Shaking-B may be required for nociceptors to react properly to a cold stimulus. Ogre was revealed to have an apparent inverse effect, in which Drosophila larvae responded more strongly to a cold stimulus when lacking the gene producct. These studies indicate that Innexins probably do play a role in the peripheral nervous system and in reacting to noxious cold stimuli.
Author | : Wolfgang B. Liedtke, MD, PH.D. |
Publisher | : CRC Press |
Total Pages | : 502 |
Release | : 2006-09-29 |
Genre | : Medical |
ISBN | : 1420005847 |
Download TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book in PDF, ePub and Kindle
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author | : Ruth Eatock |
Publisher | : Springer Science & Business Media |
Total Pages | : 465 |
Release | : 2006-07-01 |
Genre | : Science |
ISBN | : 0387317066 |
Download Vertebrate Hair Cells Book in PDF, ePub and Kindle
The Springer Handbook of Auditory Research presents a series of compreh- sive and synthetic reviews of the fundamental topics in modern auditory - search. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in ?elds of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.
Author | : Frank Zufall |
Publisher | : Academic Press |
Total Pages | : 432 |
Release | : 2016-02-18 |
Genre | : Science |
ISBN | : 0128017864 |
Download Chemosensory Transduction Book in PDF, ePub and Kindle
Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included
Author | : |
Publisher | : Academic Press |
Total Pages | : 546 |
Release | : 2021-03-09 |
Genre | : Science |
ISBN | : 0128152826 |
Download Molecular Mechanisms of Neural Development and Insights into Disease Book in PDF, ePub and Kindle
Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series
Author | : John N. Wood |
Publisher | : Oxford University Press, USA |
Total Pages | : 939 |
Release | : 2020 |
Genre | : Medical |
ISBN | : 0190860502 |
Download The Oxford Handbook of the Neurobiology of Pain Book in PDF, ePub and Kindle
This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online.
Author | : Howard L. Fields |
Publisher | : Elsevier Publishing Company |
Total Pages | : 454 |
Release | : 1988-01-01 |
Genre | : Medical |
ISBN | : 9780444809841 |
Download Pain Modulation Book in PDF, ePub and Kindle
This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Author | : Jerome Engel Jr |
Publisher | : Oxford University Press |
Total Pages | : 737 |
Release | : 2013-01-31 |
Genre | : Medical |
ISBN | : 019532854X |
Download Seizures and Epilepsy Book in PDF, ePub and Kindle
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.