Molecular Mechanisms of Nociception
Author | : Fabien Marchand |
Publisher | : Frontiers Media SA |
Total Pages | : 207 |
Release | : 2022-10-17 |
Genre | : Science |
ISBN | : 2832502555 |
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Author | : Fabien Marchand |
Publisher | : Frontiers Media SA |
Total Pages | : 207 |
Release | : 2022-10-17 |
Genre | : Science |
ISBN | : 2832502555 |
Author | : Donald Iain MacDonald |
Publisher | : |
Total Pages | : |
Release | : 2020 |
Genre | : |
ISBN | : |
Author | : Stephen P. Hunt |
Publisher | : Molecular and Cellular Neurobi |
Total Pages | : 422 |
Release | : 2005 |
Genre | : Medical |
ISBN | : 9780198515616 |
The last decade has seen major advances in the neurobiology of pain, primarily resulting from a deeper understanding of the way in which pain signals are coded and processed in the nervous system. This volume in the Molecular and Cellular Neurobiology is the first book for many years to present an integrated overview of the current state of research into the neurobiology of chronic and acute pain. While recent molecular aspects of nociception are covered in some detail, the book also emphasises the importance of viewing the pain experience as the co-ordinated response of many different areas of the nervous system. The molecular advances are set in the context of the neurobiological system of pain processing. The appropriate behavioural response to injury can therefore be thought of as the result of the integration of information processed within areas of the brain concerned with cognition, affect, sensory discrimination and movement. Chapters cover recent advances in nociceptor transduction mechanisms, nociceptor plasticity and the biochemical anatomy of pain pathways. Other contributions are concerned with the development of pain systems and with the central processing of nociceptive information studied with brain imaging techniques. Several chapters additionally cover the mechanisms of clinically important pain states such as neuropathic pain, cancer related pain and migraine. A new volume in the Molecular and Cellular Neurobiology series, this volume presents a state-of-the-art account of the neurobiological basis of pain, edited and written by the leading scientists in this field.
Author | : Ilia V. Rogachevskii |
Publisher | : Frontiers in Pain Science |
Total Pages | : 212 |
Release | : 2017-06-12 |
Genre | : Medical |
ISBN | : 9781608059317 |
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor ? Na+,K+-ATPase ? NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Author | : Wuping Sun |
Publisher | : Frontiers Media SA |
Total Pages | : 141 |
Release | : 2022-02-22 |
Genre | : Science |
ISBN | : 2889744663 |
Author | : Howard L. Fields |
Publisher | : Elsevier Publishing Company |
Total Pages | : 454 |
Release | : 1988-01-01 |
Genre | : Medical |
ISBN | : 9780444809841 |
This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Author | : Raymond S. Sinatra |
Publisher | : Cambridge University Press |
Total Pages | : 729 |
Release | : 2009-04-27 |
Genre | : Medical |
ISBN | : 0521874912 |
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author | : Joyce A. De Leo |
Publisher | : |
Total Pages | : 464 |
Release | : 2007 |
Genre | : Medical |
ISBN | : |
"Review of immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states. Discussion of novel immune and glial targets for clinical pain control that may yield new analgesic drugs"--Provided by publisher.
Author | : Wolfgang B. Liedtke, MD, PH.D. |
Publisher | : CRC Press |
Total Pages | : 502 |
Release | : 2006-09-29 |
Genre | : Medical |
ISBN | : 1420005847 |
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author | : Lawrence Kruger |
Publisher | : CRC Press |
Total Pages | : 458 |
Release | : 2009-11-24 |
Genre | : Health & Fitness |
ISBN | : 1439812101 |
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical