Molecular Mechanisms Of Neurodegenerative Diseases PDF Download
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Author | : Marie-Francoise Chesselet |
Publisher | : |
Total Pages | : 428 |
Release | : 2014-01-15 |
Genre | : |
ISBN | : 9781468496024 |
Download Molecular Mechanisms of Neurodegenerative Diseases Book in PDF, ePub and Kindle
Author | : Marie-Francoise Chesselet |
Publisher | : Springer Science & Business Media |
Total Pages | : 416 |
Release | : 2000-10-19 |
Genre | : Medical |
ISBN | : 1592590063 |
Download Molecular Mechanisms of Neurodegenerative Diseases Book in PDF, ePub and Kindle
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Author | : Nagehan Ersoy Tunalı |
Publisher | : BoD – Books on Demand |
Total Pages | : 180 |
Release | : 2021-01-20 |
Genre | : Science |
ISBN | : 1838801499 |
Download Neurodegenerative Diseases Book in PDF, ePub and Kindle
Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.
Author | : Michael S. Wolfe |
Publisher | : Academic Press |
Total Pages | : 561 |
Release | : 2018-03-29 |
Genre | : Medical |
ISBN | : 0128113057 |
Download The Molecular and Cellular Basis of Neurodegenerative Diseases Book in PDF, ePub and Kindle
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Author | : Robert Crichton |
Publisher | : John Wiley & Sons |
Total Pages | : 240 |
Release | : 2006-05-01 |
Genre | : Medical |
ISBN | : 0470022566 |
Download Metal-based Neurodegeneration Book in PDF, ePub and Kindle
This exciting new book opens a window into the causes ofdebilitating neurological disorders such as Parkinson’sdisease, CJD and Huntington’s disease, and gives indicationsof the prospects for therapy, based on the understanding ofmolecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the bookoutlines the role of metals in human biology, in particular in thebrain and explores tools for testing potential therapeuticstrategies. It concludes with an overview of the potential of bothchelation and antioxidant therapy and outlines some perspectivesfor the future.
Author | : Wilma Wasco |
Publisher | : Springer Science & Business Media |
Total Pages | : 313 |
Release | : 1996-11-01 |
Genre | : Medical |
ISBN | : 1592594719 |
Download Molecular Mechanisms of Dementia Book in PDF, ePub and Kindle
The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.
Author | : Dennis Dickson |
Publisher | : John Wiley & Sons |
Total Pages | : 497 |
Release | : 2011-09-09 |
Genre | : Medical |
ISBN | : 1444341235 |
Download Neurodegeneration Book in PDF, ePub and Kindle
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Author | : Florian Lang |
Publisher | : Springer Science & Business Media |
Total Pages | : 2348 |
Release | : 2009-03-19 |
Genre | : Science |
ISBN | : 3540671366 |
Download Encyclopedia of Molecular Mechanisms of Disease Book in PDF, ePub and Kindle
This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.
Author | : Akhlaq A. Farooqui |
Publisher | : Bentham Science Publishers |
Total Pages | : 156 |
Release | : 2011-01-26 |
Genre | : Science |
ISBN | : 1608050920 |
Download Molecular Aspects of Neurodegeneration and Neuroprotection Book in PDF, ePub and Kindle
"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"
Author | : Patrik Verstreken |
Publisher | : Academic Press |
Total Pages | : 332 |
Release | : 2016-12-19 |
Genre | : Medical |
ISBN | : 0128038055 |
Download Parkinson's Disease Book in PDF, ePub and Kindle
Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease