Molecular Genetic Alterations in Endometrial Cancer
Author | : Bahman Saffari |
Publisher | : |
Total Pages | : 304 |
Release | : 1998 |
Genre | : |
ISBN | : |
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Author | : Bahman Saffari |
Publisher | : |
Total Pages | : 304 |
Release | : 1998 |
Genre | : |
ISBN | : |
Author | : Lora Hedrick Ellenson |
Publisher | : Springer |
Total Pages | : 284 |
Release | : 2016-12-01 |
Genre | : Medical |
ISBN | : 3319431390 |
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author | : Anjila Koul |
Publisher | : |
Total Pages | : 105 |
Release | : 2001 |
Genre | : |
ISBN | : 9789162849405 |
Author | : Yue Wang |
Publisher | : Open Dissertation Press |
Total Pages | : 256 |
Release | : 2017-01-26 |
Genre | : Medical |
ISBN | : 9781361111246 |
This dissertation, "Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas" by Yue, Wang, 王悦, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas Submitted by Wang Yue for the degree of Doctor of Philosophy at The University of Hong Kong in June 2005 Recently, mitochondrial DNA (mtDNA) mutations and genetic instability were frequently detected in a number of human cancers. However, the occurrence of mtDNA alterations in endometrial carcinomas is still unknown. This study aims to identify the frequency and characteristics of mtDNA alterations in endometrial carcinomas. To identify somatic mtDNA mutations, DNA sequencing was performed on the mutational hotspot region of mtDNA in endometrial carcinomas and matched normal controls. The frequency of the T→C polymorphism at nucleotide position (np) 16189 was also determined in endometrial carcinomas and compared with the frequencies detected in cervical, ovarian and breast cancers as well as in the general population. The mitochondrial microsatellite instability (mtMSI) in the above four types of cancers was also evaluated. The nuclear MSI (nMSI), the germline mutations of the core genes of the mismatch repair system and methylation status of hMLH1, APC INK4A and p16, were also studied in endometrial carcinomas. 1The copy number of mtDNA in endometrial cancer cells procured by laser capture microdissection (LCM) was determined by real-time quantitative PCR and compared with normal endometrial cells obtained from the same patient. Moreover, by using LCM, mtDNA sequence alterations were analyzed on different loci from the same lesion of a subset of endometrial carcinomas. Finally, the mtDNA copy number and the expression level of mtDNA-encoded genes on estrogen-sensitive RL95-2 cells were quantified by real time PCR, RT-PCR and Western blotting assays. A remarkably high frequency (56%, 28/50) of somatic mtDNA mutations in endometrial carcinomas was observed. MtMSI constituted the majority (89%, 25/28) of the somatic changes detected. And the frequency of mtMSI was significantly higher than the other three types of cancers including cervical, ovarian and breast cancers (χ, P
Author | : |
Publisher | : |
Total Pages | : 177 |
Release | : 2017 |
Genre | : |
ISBN | : 9789462955035 |
Author | : Michael T. Deavers |
Publisher | : Springer |
Total Pages | : 288 |
Release | : 2017-10-28 |
Genre | : Medical |
ISBN | : 3319579851 |
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Author | : Paola Viganò |
Publisher | : MDPI |
Total Pages | : 378 |
Release | : 2019-10-14 |
Genre | : Social Science |
ISBN | : 3039214950 |
The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]
Author | : Antonio Giordano |
Publisher | : Springer Science & Business Media |
Total Pages | : 226 |
Release | : 2007-10-05 |
Genre | : Medical |
ISBN | : 1597453463 |
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. It approaches research into the pathology and treatment of gynecologic oncology from both clinical and experimental perspectives. New insights made possible by the introduction of advanced technologies into the field are presented. This new volume will be necessary reading for clinicians and experimental researchers alike.
Author | : Eric J. Bieber |
Publisher | : Cambridge University Press |
Total Pages | : 1127 |
Release | : 2015-04-23 |
Genre | : Medical |
ISBN | : 1107040396 |
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Author | : |
Publisher | : Academic Press |
Total Pages | : 343 |
Release | : 1995-11-22 |
Genre | : Science |
ISBN | : 0080562493 |
Advances in Cancer Research is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Topics covered in Volume 67 include a developmental model of progenitor cell oncogenesis based on a description of transcriptional control; pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples; the genetics of murine lung tumors; the molecular pathogenesis of AIDS-related lymphomas; HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development; a summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis. There are two reviews discussing angiogenesis: the first focuses on the role of scatter factor and the second, the VEGF-FH receptor system. The "Foundations in Cancer Research" article by Alfred G. Knudson is a personal account of his career studying mutation and cancer. A "Foundations in Cancer Research" article by Alfred G. Knudson, a personal account of his career studying mutation and cancer A developmental model of progenitor cell oncogenesis based on a disruption of transcriptional control Pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples A review of the genetics of murine lung tumors Molecular pathogenesis of AIDS-related lymphomas HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development A summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis The role of scatter factor in angiogenesis The role of the VEGF-FH receptor system in normal and tumor angiogenesis