Molecular Dynamics In Biological Membranes PDF Download
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Author | : Milton H.Jr. Saier |
Publisher | : Springer Science & Business Media |
Total Pages | : 140 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 146139399X |
Download Molecular Dynamics in Biological Membranes Book in PDF, ePub and Kindle
Author | : Kenneth M. Merz |
Publisher | : Springer Science & Business Media |
Total Pages | : 596 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1468485806 |
Download Biological Membranes Book in PDF, ePub and Kindle
The interface between a living cell and the surrounding world plays a critical role in numerous complex biological processes. Sperm/egg fusion, virus/cell fusion, exocytosis, endocytosis, and ion permeation are a few examples of processes involving membranes. In recent years, powerful tools such as X-ray crystal lography, electron microscopy, nuclear magnetic resonance, and infra-red and Raman spectroscopy have been developed to characterize the structure and dy namics of biomembranes. Despite this progress, many of the factors responsible for the function of biomembranes are still not well understood. The membrane is a very complicated supramolecular liquid-crystalline structure that is largely composed of lipids, forming a bilayer, to which proteins and other biomolecules are anchored. Often, the lipid bilayer environment is pictured as a hydropho bic structureless slab providing a thermodynamic driving force to partition the amino acids of a membrane protein according to their solubility. However, much of the molecular complexity of the phospholipid bilayer environment is ignored in such a simplified view. It is likely that the atomic details of the polar head group region and the transition from the bulk water to the hydrophobic core of the membrane are important. An understanding of the factors responsible for the function of biomembranes thus requires a better characterization at the molec ular level of how proteins interact with lipid molecules, of how lipids affect protein structure and of how lipid molecules might regulate protein function.
Author | : Mu-Ping Nieh |
Publisher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 532 |
Release | : 2019-07-22 |
Genre | : Science |
ISBN | : 3110544687 |
Download Characterization of Biological Membranes Book in PDF, ePub and Kindle
The study of membranes has become of high importance in the fields of biology, pharmaceutical chemistry and medicine, since much of what happens in a cell or in a virus involves biological membranes. The current book is an excellent introduction to the area, which explains how modern analytical methods can be applied to study biological membranes and membrane proteins and the bioprocesses they are involved to.
Author | : Mark S. P. Sansom |
Publisher | : Royal Society of Chemistry |
Total Pages | : 272 |
Release | : 2010 |
Genre | : Science |
ISBN | : 0854041893 |
Download Molecular Simulations and Biomembranes Book in PDF, ePub and Kindle
The need for information in the understanding of membrane systems has been caused by three things - an increase in computer power; methodological developments and the recent expansion in the number of researchers working on it worldwide. However, there has been no up-to-date book that covers the application of simulation methods to membrane systems directly and this book fills an important void in the market. It provides a much needed update on the current methods and applications as well as highlighting recent advances in the way computer simulation can be applied to the field of membranes and membrane proteins. The objectives are to show how simulation methods can provide an important contribution to the understanding of these systems. The scope of the book is such that it covers simulation of membranes and membrane proteins, but also covers the more recent methodological developments such as coarse-grained molecular dynamics and multiscale approaches in systems biology. Applications embrace a range of biological processes including ion channel and transport proteins. The book is wide ranging with broad coverage and a strong coupling to experimental results wherever possible, including colour illustrations to highlight particular aspects of molecular structure. With an internationally respected list of authors, its publication is timely and it will prove indispensable to a large scientific readership.
Author | : V. Sundararajan |
Publisher | : Academic Press |
Total Pages | : 493 |
Release | : 2011-08-29 |
Genre | : Science |
ISBN | : 0080879705 |
Download Computational Modeling of Membrane Bilayers Book in PDF, ePub and Kindle
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. *Discusses the current stat of electrostatics in biomolecular simulations and future directions *Includes information on time and length scales in lipid bilayer simulations *Includes a chapter on the nature of lipid rafts
Author | : Julita Kulbacka |
Publisher | : Springer |
Total Pages | : 145 |
Release | : 2017-10-04 |
Genre | : Medical |
ISBN | : 3319568957 |
Download Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy Book in PDF, ePub and Kindle
This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics. The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).
Author | : |
Publisher | : |
Total Pages | : 78 |
Release | : 2012 |
Genre | : |
ISBN | : |
Download Molecular Dynamics Simulations of Biological Membranes Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 554 |
Release | : 2020-03-05 |
Genre | : Science |
ISBN | : 0128211377 |
Download Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly Book in PDF, ePub and Kindle
Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly, Volume 170 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Pairwise-Additive and Polarizable Atomistic Force Fields for Molecular Dynamics Simulations of Proteins, Scale-consistent approach to the derivation of coarse-grained force fields for simulating structure, dynamics, and thermodynamics of biopolymers, Enhanced sampling and free energy methods, and much more. Includes comprehensive coverage on molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Author | : Daniel L. Parton |
Publisher | : |
Total Pages | : |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Pushing the Boundaries Book in PDF, ePub and Kindle
A range of simulations have been conducted to investigate the behaviour of a diverse set of complex biological membrane systems. The processes of interest have required simulations over extended time and length scales, but without sacrifice of molecular detail. For this reason, the primary technique used has been coarse-grained molecular dynamics (CG MD) simulations, in which small groups of atoms are combined into lower-resolution CG particles. The increased computational efficiency of this technique has allowed simulations with time scales of microseconds, and length scales of hundreds of nm. The membrane-permeabilizing action of the antimicrobial peptide maculatin 1.1 was investigated. This short [alpha]-helical peptide is thought to kill bacteria by permeabilizing the plasma membrane, but the exact mechanism has not been confirmed. Multiscale (CG and atomistic) simulations show that maculatin can insert into membranes to form disordered, water-permeable aggregates, while CG simulations of large numbers of peptides resulted in substantial deformation of lipid vesicles. The simulations imply that both pore-forming and lytic mechanisms are available to maculatin 1.1, and that the predominance of either depends on conditions such as peptide concentration and membrane composition. A generalized study of membrane protein aggregation was conducted via CG simulations of lipid bilayers containing multiple copies of model transmembrane proteins: either [alpha]-helical bundles or [beta]-barrels. By varying the lipid tail length and the membrane type (planar bilayer or spherical vesicle), the simulations display protein aggregation ranging from negligible to extensive; they show how this biologically important process is modulated by hydrophobic mismatch, membrane curvature, and the structural class or orientation of the protein. The association of influenza hemagglutinin (HA) with putative lipid rafts was investigated by simulating aggregates of HA in a domain-forming membrane. The CG MD study addressed an important limitation of model membrane experiments by investigating the influence of high local protein concentration on membrane phase behaviour. The simulations showed attenuated diffusion of unsaturated lipids within HA aggregates, leading to spontaneous accumulation of raft-type lipids (saturated lipids and cholesterol). A CG model of the entire influenza viral envelope was constructed in realistic dimensions, comprising the three types of viral envelope protein (HA, neuraminidase and M2) inserted into a large lipid vesicle. The study represents one of the largest near-atomistic simulations of a biological membrane to date. It shows how the high concentration of proteins found in the viral envelope can attenuate formation of lipid domains, which may help to explain why lipid rafts do not form on large scales in vivo.
Author | : Max L. Berkowitz |
Publisher | : CRC Press |
Total Pages | : 334 |
Release | : 2019-04-30 |
Genre | : Science |
ISBN | : 1351060295 |
Download Biomembrane Simulations Book in PDF, ePub and Kindle
Due to recent advancements in the development of numerical algorithms and computational hardware, computer simulations of biological membranes, often requiring use of substantial computational resources, are now reaching a mature stage. Since molecular processes in membranes occur on a multitude of spatial and time scales, molecular simulations of membranes can also serve as a testing ground for use of multi-scale simulation techniques. This book addresses some of the important issues related to understanding properties and behavior of model biological membranes and it Shows how simulations improve our understanding of biological membranes and makes connections with experimental results. Presents a careful discussion of the force fields used in the membrane simulations including detailed all-atom fields and coarse-grained fields. Presents a continuum description of membranes. Discusses a variety of issues such as influence of membrane surfaces on properties of water, interaction between membranes across water, nanoparticle permeation across the membrane, action of anesthetics and creation of inhomogeneous regions in membranes. Discusses important methodological issues when using simulations to examine phenomena such as pore creation and permeation across membranes. Discusses progress recently achieved in modeling bacterial membranes. It will be a valuable resource for graduate students, researchers and instructors in biochemistry, biophysics, pharmacology, physiology, and computational biology.