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Molecular, Cellular, and Tissue Engineering of the Vascular System

Molecular, Cellular, and Tissue Engineering of the Vascular System
Author: Bingmei M. Fu
Publisher: Springer
Total Pages: 334
Release: 2018-10-12
Genre: Science
ISBN: 3319964453

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This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanisms of atherosclerotic plaque microcalcifications and human abdominal aortic aneurysms, experiments and modelling for red blood cell and tumor cell movement in microcirculation, transport across the blood-brain barrier and its role in Alzheimer’s disease, mathematical models for cell survival after hyperthermia, application of hypothermia in enhancing treatment for brain and spinal cord injuries, and damage of eardrums due to blast waves. This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.


Molecular, Cellular, and Tissue Engineering

Molecular, Cellular, and Tissue Engineering
Author: Joseph D. Bronzino
Publisher: CRC Press
Total Pages: 1891
Release: 2018-10-08
Genre: Medical
ISBN: 1439825319

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Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine. More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.


Vascular Tissue Engineering

Vascular Tissue Engineering
Author: Feng Zhao
Publisher: Humana
Total Pages: 0
Release: 2022-10-02
Genre: Science
ISBN: 9781071617106

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This volume explores the latest techniques used to study the field of tissue engineered vascular grafts (TEVGs). The chapters in this book cover a wide array of topics such as deriving vascular cells from monocytes and induced pluripotent stem cells; engineering vascular grafts using various biomaterials and stem cells, stem cell-derived, or primary vascular cells; biomaterial modification by anticoagulation molecules; vascular bioengineering technologies such as 3D bioprinting; and fabrication of TEVGs with different geometry and multiphase structures. This book also features protocols for grafting and evaluation of vascular grafts in animal models, vascular imaging in animals, and the quantification of blood vessel permeability. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vascular Tissue Engineering: Methods and Protocols is a valuable resource for biomedical engineers, cell biologists, vascular surgeons, doctors, and nurses.


Principles of Cellular Engineering

Principles of Cellular Engineering
Author: Michael R. King
Publisher: Elsevier
Total Pages: 339
Release: 2011-04-28
Genre: Science
ISBN: 0080539637

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This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine. -Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications -Useful to researchers in biomaterials, inflammation, and vascular biology -Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses


Tissue Engineering

Tissue Engineering
Author: Jan De Boer
Publisher: Elsevier
Total Pages: 760
Release: 2008-04-14
Genre: Science
ISBN: 9780080559193

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Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students and professionals who are developing their knowledge of this important topic. Key topics covered include stem cells; morphogenesis and cellular signaling; the extracellular matrix; biocompatibility; scaffold design and fabrication; controlled release strategies; bioreactors; tissue engineering of skin, cartilage, bone and organ systems; and ethical issues. Covers all the essentials from tissue homeostasis and biocompatibility to cardiovascular engineering and regulations 22 chapters from internationally recognized authors, provide a comprehensive introduction for engineers and life scientists, including biomedical engineers, chemical and process engineers, materials scientists, biologists and medical students Full colour throughout, with clear development of understanding through frequent examples, experimental approaches and the latest research and developments


Tissue Engineering

Tissue Engineering
Author: Clemens van Blitterswijk
Publisher: Academic Press
Total Pages: 800
Release: 2022-11-11
Genre: Science
ISBN: 0323851347

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Tissue Engineering, Third Edition provides a completely revised release with sections focusing on Fundamentals of Tissue Engineering and Tissue Engineering of Selected Organs and Tissues. Key chapters are updated with the latest discoveries, including coverage of new areas (skeletal TE, ophthalmology TE, immunomodulatory biomaterials and immune systems engineering). The book is written in a scientific language that is easily understood by undergraduate and graduate students in basic biological sciences, bioengineering and basic medical sciences, and researchers interested in learning about this fast-growing field. Presents a clear structure of chapters that is aimed at those new to the field Includes new chapters on immune systems engineering, skeletal tissue engineering (skeletal muscle, tendon, and ligament) eye, cornea and ophthalmology tissue engineering Includes applied clinical cases studies that illustrate basic science applications


Vascular Engineering

Vascular Engineering
Author: Kazuo Tanishita
Publisher: Springer
Total Pages: 401
Release: 2016-03-17
Genre: Medical
ISBN: 4431548017

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This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.


Bioregenerative Engineering

Bioregenerative Engineering
Author: Shu Q. Liu
Publisher: John Wiley & Sons
Total Pages: 1106
Release: 2007-04-06
Genre: Science
ISBN: 0470116854

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A unique, comprehensive reference that integrates the molecular, cellular, physiological, pathological, and engineering aspects of regenerative processes Bioregenerative engineering is an emerging discipline based on applying engineering principles and technologies to regenerative medicine. It induces, modulates, enhances, and/or controls regenerative processes by using engineering approaches to improve the restoration of the structure and function of disordered or lost molecules, cells, tissues, and organs. This reference systematically summarizes bioregenerative engineering principles, technologies, and current research to help scientists understand biological regeneration and design new therapeutic strategies. Succinct and well-organized with a detailed table of contents to help readers pinpoint information, this reference: * Provides the fundamental theory and principles of molecular, cellular, and tissue regenerative engineering concurrently with experimental approaches * Presents the foundations of bioregenerative engineering, encompassing the molecular basis, the regulatory mechanism of regeneration, and the developmental aspects * Combines molecular and cell biology with potential applications * Addresses experimental design, methods, and modeling at the molecular/cellular/tissue levels * Covers the general mechanisms and technologies of bioregenerative engineering, as well as its application to the treatment of human disorders * Discusses the engineering tests and therapies for major organ systems Presenting an in-depth introduction to the biological and engineering aspects of the field and an up-to-date overview of current research, this is a one-of-a-kind resource for scientific researchers and medical practitioners, as well as for graduate and undergraduate students in biomedical engineering, bioengineering, chemical engineering, molecular biology, and cell biology.


Principles of Tissue Engineering

Principles of Tissue Engineering
Author: Robert Lanza
Publisher: Academic Press
Total Pages: 1344
Release: 2011-10-13
Genre: Science
ISBN: 0080548849

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First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike. New to this edition:*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems


Biomaterials for Vasculogenesis and Angiogenesis

Biomaterials for Vasculogenesis and Angiogenesis
Author: Saeid Kargozar
Publisher: Woodhead Publishing
Total Pages: 522
Release: 2022-05-19
Genre: Medical
ISBN: 0128218681

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Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an important role in tissue engineering and regenerative medicine research by promoting vascular networks inside engineered tissues and thereby increasing tissue healing and regeneration. However, researchers are faced with the challenge of finding suitable materials for improving angiogenesis and vascular formation in assays. This book reviews a broad range of biomaterials for the promotion of blood vessel genesis, from polymers and bioactive glass, to nanomaterial scaffolds and 3D angiogenic constructs. In addition, the book covers a variety of applications for biomaterials in tissue repair and regeneration, including cardiovascular regeneration, liver tissue engineering and much more. It will serve as a detailed reference for researchers in academia and industry, working in the fields of biomedical science and engineering, materials science, regenerative medicine and translational medicine. Introduces readers to the molecular and cellular basis of angiogenesis and vasculogenesis Helps researchers find suitable biomaterials to promote angiogenesis in engineered tissues and assays Describes a range of biomaterials and their properties, including glass-ceramics, nano-carriers, polymers, and more