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Modulating Verbal Episodic Memory Encoding with Transcranial Electrical Stimulation

Modulating Verbal Episodic Memory Encoding with Transcranial Electrical Stimulation
Author: Gabriel Amador de Lara
Publisher:
Total Pages:
Release: 2018
Genre:
ISBN:

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Non-invasive brain stimulation (NIBS) are techniques widely employed in the last decades to the study of physiology of cognitive processes, and bring the promise of being a complementary therapeutic intervention to neuropsychiatric disorders. In this doctoral dissertation, I attempted to advance in methodologically rigorous protocols to influence normal brain physiology and search for solutions to modulate memory activity, targeting different anatomical nodes of the verbal episodic memory network with transcranial electrical stimulation (tDCS, TACS). In the first study, I aimed to modulate ...


Non-Invasive Brain Stimulation: New Prospects in Cognitive Neurorehabilitation

Non-Invasive Brain Stimulation: New Prospects in Cognitive Neurorehabilitation
Author: Carlo Professor Miniussi
Publisher: Psychology Press
Total Pages: 218
Release: 2012-12-06
Genre: Psychology
ISBN: 1135849153

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Cognitive deficits are a common consequence of neurological disease, and there is evidence that specific cognitive training may be effective in rehabilitation. Behavioural dysfunction following neurological disease constitutes one of the major causes of disability worldwide, exerts a major impact on the daily life of affected individuals, and their families, also with a financial burden both for patients, and the society in general. Therefore, the adequate treatment of cognitive dysfunction is a much relevant issue, with social and economical implications, over and above the neuropsychological problem per se. Several investigations emphasise the fact that interacting with neural activity, by means of cortical stimulation, can affect cognitive performance. A number of studies have reported enhanced performance in specific cognitive tasks in patients with several types of neurological disease, after receiving Non Invasive Brain Stimulation (NIBS) to specific cortical areas, namely: Transcranial Magnetic Stimulation, and transcranial Electrical Stimulation. In general, the evidence highlights the possibility of inducing changes in cortical excitability, which, in turn, may lead to a plastic reorganization of dysfunctional networks, responsible for the impaired cognitive functions. Despite these advances, a number of important questions remain open, regarding the use of stimulation techniques in cognitive rehabilitation. This special issue puts together international leading experts in the field, to review and discuss recent advances as to whether NIBS techniques alone, or combined with behavioural cognitive rehabilitation, can lead to performance enhancements, and why. The issue is timely and promises to have a huge impact across many domains of clinical and basic neuroscience.


Neural Mechanisms of Episodic Memory Formation

Neural Mechanisms of Episodic Memory Formation
Author: Nicole Marie Long
Publisher:
Total Pages: 228
Release: 2015
Genre:
ISBN:

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In order to remember what you had for breakfast today, you must rely on episodic memory, the memory for personal events situated within a spatiotemporal context. In this dissertation, I use electroencephalographic (EEG) recordings to measure the neural correlates of successful episodic memory formation. The recorded EEG signals simultaneously sample local field potentials throughout the brain, and can be analyzed in terms of specific time-varying oscillatory or spectral components of neural activity which are thought to reflect the concerted activity of neuronal populations. I collected EEG recordings while participants engage in free recall, an episodic memory task during which participants must study and then recall a list of items. In the first chapter, I compare the spectral correlates during encoding of items later remembered to those later forgotten using two separate recording modalities, scalp and intracranial EEG. I find that memory formation is characterized by broad low frequency spectral power decreases and high frequency power increases across both datasets, suggesting that scalp EEG can resolve high frequency activity (HFA) and that low frequency decreases in intracranial EEG are unlikely due to pathology. In the next chapter, I connect these HFA increases to memory-specific processes by comparing study items based on how they are recalled, not whether they are recalled. I find increased HFA in left lateral cortex and hippocampus during the encoding of subsequently clustered items, those items recalled consecutively with their study neighbors at test. The precise time course of these results suggests that context updating mechanisms and item-to-context associative mechanisms support successful memory formation. In the third chapter, I measure how the formation of these episodic associations is modulated by pre-existing semantic associations by including a semantic orienting task during the encoding interval. I find that semantic processing interferes with the formation of new, episodic memories. In the final chapter, I show that the memory benefit for emotionally valenced items is better explained by a contextual mechanism than an attentional mechanism. Together, my work supports the theory that contextual encoding associative mechanisms, reflected by HFA increases in the memory network, support memory formation.


The Stimulated Brain

The Stimulated Brain
Author: Roi Cohen Kadosh
Publisher: Elsevier
Total Pages: 568
Release: 2014-06-01
Genre: Medical
ISBN: 0124047122

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The Stimulated Brain—which garnered an Honorable Mention for Biomedicine & Neuroscience at the 2015 PROSE Awards from the Association of American Publishers—presents the first integration of findings on brain stimulation from different research fields with a primary focus on Transcranial Electrical Stimulation (tES), one of the most frequently used noninvasive stimulation methods. The last decade has witnessed a significant increase in the amount of research exploring how noninvasive brain stimulation can not only modulate but also enhance cognition and brain functions. However, although Transcranial Magnetic Stimulation (TMS) and particularly tES have the potential to become more widely applicable techniques (as they come with none of the risks associated with deep brain stimulation) the reference literature on these neurotechnologies has been sparse. This resource provides a broad survey of current knowledge, and also marks future directions in cognitive and neuro-enhancement. It expands our understanding of basic research findings from animals and humans, including clear translational benefits for applied research and the therapeutic use of noninvasive brain stimulation methods. The book's coverage includes a primer that paves the way to a more advanced knowledge of tES and its physiological basis; current research findings on cognitive and neuro-enhancement in animals and typical and atypical human populations, such as neurological patients; and discussions of future directions, including specific neuroethical issues and pathways for collaboration and entrepreneurialism. The Stimulated Brain is the first book to provide a comprehensive understanding of different aspects of noninvasive brain stimulation that are critical for scientists, clinicians, and those who are interested in “stimulating their minds by exploring this fascinating field of research. Honorable Mention for Biomedicine & Neuroscience in the 2015 PROSE Awards from the Association of American Publishers The only reference on the market to focus on transcranial electrical stimulation (tES) Coverage across technical, historical, and application topics makes this the single, comprehensive resource for researchers and students Edited book with chapters authored by international leaders in the fields of medicine, neuroscience, psychology, and philosophy—providing the broadest, most expert coverage available


The Oxford Handbook of Human Memory, Two Volume Pack

The Oxford Handbook of Human Memory, Two Volume Pack
Author: Michael J. Kahana
Publisher: Oxford University Press
Total Pages: 2426
Release: 2024-04-26
Genre: Psychology
ISBN: 0197746144

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The Oxford Handbook of Human Memory provides an authoritative overview of the science of human memory, its application to clinical disorders, and its broader implications for learning and memory in real-world contexts. Organized into two volumes and eleven sections, the Handbook integrates behavioral, neural, and computational evidence with current theories of how we learn and remember. Overall, The Oxford Handbook of Human Memory documents the current state of knowledge in the field and provides a roadmap for the next generation of memory scientists, established peers, and practitioners.


Progress in Episodic Memory Research

Progress in Episodic Memory Research
Author: Ekrem Dere
Publisher: Frontiers Media SA
Total Pages: 515
Release: 2016-05-25
Genre: Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN: 2889198472

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Episodic memory refers to the ability to remember personal experiences in terms of what happened and where and when it happened. Humans are also able to remember the specific perceptions, emotions and thoughts they had during a particular experience. This highly sophisticated and unique memory system is extremely sensitive to cerebral aging, neurodegenerative and neuropsychiatric diseases. The field of episodic memory research is a continuously expanding and fascinating area that unites a broad spectrum of scientists who represent a variety of research disciplines including neurobiology, medicine, psychology and philosophy. Nevertheless, important questions still remain to be addressed. This research topic on the Progress in Episodic Memory Research covers past and current directions in research dedicated to the neurobiology, neuropathology, development, measurement and treatment of episodic memory.


Oxford Handbook of Transcranial Stimulation

Oxford Handbook of Transcranial Stimulation
Author: Eric Wassermann
Publisher: OUP Oxford
Total Pages: 768
Release: 2008-01-25
Genre: Medical
ISBN: 0191546747

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Since becoming commercially available in 1985, transcranial magnetic stimulation (TMS) has emerged as an important tool in several areas of neuroscience. Originally envisioned as a way to measure the responsiveness and conduction speed of neurons and synapses in the brain and spinal cord, TMS has also become an important tool for changing the activity of brain neurons and the functions they subserve and an important adjunct to brain imaging and mapping techniques. Along with transcranial electrical stimulation techniques, TMS has diffused far beyond the borders of clinical neurophysiology and into cognitive, perceptual, behavioural, and therapeutic investigation and attracted a highly diverse group of users and would-be users. This book provides an authoritative review of the scientific and technical background required to understand transcranial stimulation techniques and a wide-ranging survey of their burgeoning application in neurophysiology, perception, cognition, emotion, and clinical practice. Each of its six sections deals with a major area and is edited by an international authority therein. It will serve researchers, clinicians, students, and others as the definitive text in this area for years to come.