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Modelling the Toxicity of Nanoparticles

Modelling the Toxicity of Nanoparticles
Author: Lang Tran
Publisher: Springer
Total Pages: 360
Release: 2017-02-06
Genre: Medical
ISBN: 3319477544
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In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.

Model Organisms to Study Biological Activities and Toxicity of Nanoparticles

Model Organisms to Study Biological Activities and Toxicity of Nanoparticles
Author: Busi Siddhardha
Publisher: Springer Nature
Total Pages: 466
Release: 2020-03-28
Genre: Medical
ISBN: 9811517029
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This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.

Toxicology of Nanoparticles: Insights from Drosophila

Toxicology of Nanoparticles: Insights from Drosophila
Author: Namita Agrawal
Publisher: Springer Nature
Total Pages: 128
Release: 2020-08-24
Genre: Medical
ISBN: 9811555222
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This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Engineered Nanoparticles and the Environment

Engineered Nanoparticles and the Environment
Author: Baoshan Xing
Publisher: John Wiley & Sons
Total Pages: 506
Release: 2016-10-10
Genre: Science
ISBN: 1119275822
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Details the source, release, exposure, adsorption, aggregation, bioavailability, transport, transformation, and modeling of engineered nanoparticles found in many common products and applications Covers synthesis, environmental application, detection, and characterization of engineered nanoparticles Details the toxicity and risk assessment of engineered nanoparticles Includes topics on the transport, transformation, and modeling of engineered nanoparticles Presents the latest developments and knowledge of engineered nanoparticles Written by world leading experts from prestigious universities and companies

Nanotoxicity

Nanotoxicity
Author: Saura C. Sahu
Publisher: John Wiley & Sons
Total Pages: 630
Release: 2009-08-04
Genre: Science
ISBN: 047074779X
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Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessment nanotoxicity assessment by gene expression analysis in vivo and in vitro models for nanotoxicity testing mechanisms of nanotoxicity pharmakokinetics of nanomaterials nanotoxicity of foods including food processing, food packaging and food safety nanotoxicity of drugs including drug development and drug delivery nanotoxicity of cosmetics and consumer products health and environmental impact of nanotoxicity safety evaluation of nanomaterials regulatory impact of nanomaterials Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Toxicity of Nanomaterials

Toxicity of Nanomaterials
Author: Suresh C. Pillai
Publisher:
Total Pages: 0
Release: 2019
Genre: Medical
ISBN: 9780429265471
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Choice Recommended Title, April 2020 This comprehensive book, edited by two leading experts in nanotechnology and bioengineering with contributions from a global team of specialists, provides a detailed overview of the environmental and health impacts associated with the toxicology of nanomaterials. Special attention is given to nanomaterial toxicity during synthesis, production and application, and chapters throughout are focused on key areas that are important for future research and development of nanomaterials. This book will be of interest to advanced students studying biomedical engineering and materials science, PhD researchers, post-docs and academics working in the area of nanotechnology, medicine, manufacturing and regulatory bodies. Features: Collates and critically evaluates various aspects of the toxicology of nanomaterials in one comprehensive text Discusses the various effects of nanocrystals including the morphologies on cytotoxicity, in addition to the environmental and cytotoxicity risks of graphene and 2D nanomaterials Explores practical methods of detection and quantification, with applications in the environmental and healthcare fields

Silver Nanoparticles

Silver Nanoparticles
Author: Khan Maaz
Publisher:
Total Pages: 290
Release: 2018-07
Genre:
ISBN: 1789234786
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Cellular and Molecular Toxicology of Nanoparticles

Cellular and Molecular Toxicology of Nanoparticles
Author: Quaiser Saquib
Publisher: Springer
Total Pages: 356
Release: 2018-02-16
Genre: Science
ISBN: 3319720414
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This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”. The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

The ELSI Handbook of Nanotechnology

The ELSI Handbook of Nanotechnology
Author: Chaudhery Mustansar Hussain
Publisher: John Wiley & Sons
Total Pages: 580
Release: 2020-03-31
Genre: Technology & Engineering
ISBN: 1119592968
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This Handbook focuses on the recent advancements in Safety, Risk, Ethical Society and Legal Implications (ESLI) as well as its commercialization of nanotechnology, such as manufacturing. Nano is moving out of its relaxation phase of scientific route, and as new products go to market, organizations all over the world, as well as the general public, are discussing the environmental and health issues associated with nanotechnology. Nongovernmental science organizations have long since reacted; however, now the social sciences have begun to study the cultural portent of nanotechnology. Societal concerns and their newly constructed concepts, show nanoscience interconnected with the economy, ecology, health, and governance. This handbook addresses these new challenges and is divided into 7 sections: Nanomaterials and the Environment; Life Cycle Environmental Implications of Nanomanufacturing; Bioavailability and Toxicity of Manufactured Nanoparticles in Terrestrial Environments; Occupational Health Hazards of Nanoparticles; Ethical Issues in Nanotechnology; Commercialization of Nanotechnology; Legalization of Nanotechnology.

Environmental Toxicity of Nanomaterials

Environmental Toxicity of Nanomaterials
Author: Vineet Kumar
Publisher: CRC Press
Total Pages: 577
Release: 2018-04-17
Genre: Medical
ISBN: 1351252941
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Environmental Toxicity of Nanomaterials focuses on causes and prevention of environmental toxicity induced by various nanomaterials. In sixteen chapters it describes the basic principles, trends, challenges, and future directions of nanoecotoxicity. The future acceptance of nanomaterials in various industries depends on the impacts of nanomaterials on the environment and ecosystem. This book analyzes the safe utilization of nanotechnology so the tremendous prospect of nanotechnology can be achieved without harming either living beings or the environment. Environmental Toxicity of Nanomaterials introduces nanoecotoxicity, describes various factors affecting the toxicity of nanomaterials, discusses various factors that can impart nanoecotoxicity, reviews various studies in the area of nanoecotoxicity evaluation, and describes the safety and risk assessment of nanomaterials. In addition, the book discusses strategies for mitigating nanoecotoxicity. Lastly, the authors provide guidelines and protocols for nanotoxicity evaluation and discuss regulations for safety assessment of nanomaterials. In addition to environmental toxicologists, this book is aimed at policy makers, industry personnel, and doctoral and postdoctoral scholars.