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Modeling Age-dependent Gene Expression Variability in Acute Myeloid Leukemia Using a Linear Model

Modeling Age-dependent Gene Expression Variability in Acute Myeloid Leukemia Using a Linear Model
Author: Raeuf Roushangar
Publisher:
Total Pages: 176
Release: 2018
Genre: Electronic dissertations
ISBN: 9780438760592

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In 2018 alone, an estimated 20,000 new acute myeloid leukemia (AML) patients were diagnosed, in the United States, and over 10,000 of them are expected to die from the disease. Although AML can occur in people of all ages, AML is primarily diagnosed among the elderly (median 68 years old at diagnosis) and its age-specific incidence and prevalence increases exponentially after 50 years of age. Prognoses have significantly improved for younger patients, but in patients older than 60 years old, prognoses remain grim: with current treatments, as much as 70% of patients will die within a year of diagnosis. Reassessment of early diagnosis and treatment approaches therefore should be considered, since relapse after complete remission is still the main obstacle. In this study, we conducted stratified computational meta-analysis of 2,213 AML patients compared to 548 healthy individuals, using curated publicly available data. We carried out analysis of variance of normalized batch corrected data, including considerations for disease, age, tissue and sex. We identified 964 differentially expressed unique genes genes and 4 associated significant pathways involved in AML. Additionally, we have identified 69 sex- and 372 age-related gene expression signatures relevant to AML. Finally, we used a machine learning model (KNN model) to classify AML patients compared to healthy individuals with > 90% achieved accuracy. Overall our findings provide a new reanalysis of public datasets, that enabled the identification of potential new gene sets relevant to AML that can potentially be used in future experiments and possible stratified disease diagnostics.


Drug Resistance in Leukemia &

Drug Resistance in Leukemia &
Author: Gert-Jan L. Kaspers
Publisher: CRC Press
Total Pages: 458
Release: 1993-01-01
Genre: Medical
ISBN: 9783718653874

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The last ten years have seen the publication of a vast amount of data regarding cellular resistance to drugs in cancer cells. Recent studies have demonstrated that drug resistance assays appear to be predictive of clinical response and suggest that clinicians should now be considering the potential applications of these assays in the treatment of patients with hematological neoplasms. This collection of papers from the International Symposium on the Clinical Value of Drug Resistance Assays in Leukemia and Lymphoma, Amsterdam, 1992, provides a state-of-the-art discussion on drug resistance assays and their role in the design and individualization of treatment protocols.


The Zebrafish: Cellular and Developmental Biology, Part B

The Zebrafish: Cellular and Developmental Biology, Part B
Author:
Publisher: Academic Press
Total Pages: 0
Release: 2011-04-29
Genre: Technology & Engineering
ISBN: 9780123870360

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This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendium of laboratory protocols and reviews covering all the new methods developed since 1999.


Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia
Author: Ajay Vora
Publisher: Springer
Total Pages: 345
Release: 2017-04-21
Genre: Medical
ISBN: 3319397087

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This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.


Molecular Epidemiology

Molecular Epidemiology
Author: Paul A. Schulte
Publisher: Academic Press
Total Pages: 609
Release: 2012-12-02
Genre: Medical
ISBN: 0323138578

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This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.


Health Risks from Exposure to Low Levels of Ionizing Radiation

Health Risks from Exposure to Low Levels of Ionizing Radiation
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher: National Academies Press
Total Pages: 422
Release: 2006-03-23
Genre: Science
ISBN: 0309133343

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This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.


Health Effects of Exposure to Low Levels of Ionizing Radiation

Health Effects of Exposure to Low Levels of Ionizing Radiation
Author: National Research Council
Publisher: National Academies
Total Pages: 436
Release: 1990-02-01
Genre: Science
ISBN: 0309039959

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This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.


Clinical Ophthalmic Oncology

Clinical Ophthalmic Oncology
Author: Arun D. Singh
Publisher: Springer Science & Business Media
Total Pages: 159
Release: 2013-10-10
Genre: Medical
ISBN: 3642394892

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Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume guidance is provided on diagnosis and therapy for retinal tumors including vitreoretinal lymphoma and paraneoplastic disorders.


Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues

Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues
Author: World Health Organization
Publisher: IARC
Total Pages: 360
Release: 2001
Genre: Digestive organs
ISBN: 9789283224112

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This is the third volume in the new World Health Organization series on histological and genetic typing of tumours. Tumours of the haematopoietic and lymphoid tissues are covered. This was a collaborative project of the European Association for Haematolpathology and the Society for Haematopathology and others. The WHO classification is based on the principles defined in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification. Over 50 pathologists from around the world were involved in the project and proponents of all major lymphoma and leukaemia classifications have agreed to accept the WHO as the standard classification of haematological malignancies. So this classification represents the first true world wide concensus of haematologic malignancies. Colour photographs, magnetic resonance and ultrasound images and CT scans are included.


Dataset Shift in Machine Learning

Dataset Shift in Machine Learning
Author: Joaquin Quinonero-Candela
Publisher: MIT Press
Total Pages: 246
Release: 2022-06-07
Genre: Computers
ISBN: 026254587X

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An overview of recent efforts in the machine learning community to deal with dataset and covariate shift, which occurs when test and training inputs and outputs have different distributions. Dataset shift is a common problem in predictive modeling that occurs when the joint distribution of inputs and outputs differs between training and test stages. Covariate shift, a particular case of dataset shift, occurs when only the input distribution changes. Dataset shift is present in most practical applications, for reasons ranging from the bias introduced by experimental design to the irreproducibility of the testing conditions at training time. (An example is -email spam filtering, which may fail to recognize spam that differs in form from the spam the automatic filter has been built on.) Despite this, and despite the attention given to the apparently similar problems of semi-supervised learning and active learning, dataset shift has received relatively little attention in the machine learning community until recently. This volume offers an overview of current efforts to deal with dataset and covariate shift. The chapters offer a mathematical and philosophical introduction to the problem, place dataset shift in relationship to transfer learning, transduction, local learning, active learning, and semi-supervised learning, provide theoretical views of dataset and covariate shift (including decision theoretic and Bayesian perspectives), and present algorithms for covariate shift. Contributors: Shai Ben-David, Steffen Bickel, Karsten Borgwardt, Michael Brückner, David Corfield, Amir Globerson, Arthur Gretton, Lars Kai Hansen, Matthias Hein, Jiayuan Huang, Choon Hui Teo, Takafumi Kanamori, Klaus-Robert Müller, Sam Roweis, Neil Rubens, Tobias Scheffer, Marcel Schmittfull, Bernhard Schölkopf Hidetoshi Shimodaira, Alex Smola, Amos Storkey, Masashi Sugiyama