Mitochondrial Dna Mitochondria Disease And Stem Cells PDF Download
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| Author | : Justin C. St. John |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 193 |
| Release | : 2012-09-27 |
| Genre | : Science |
| ISBN | : 1627031006 |
Download Mitochondrial DNA, Mitochondria, Disease and Stem Cells Book in PDF, ePub and Kindle
This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.
| Author | : Hongzhi Sun |
| Publisher | : Springer |
| Total Pages | : 230 |
| Release | : 2017-11-25 |
| Genre | : Science |
| ISBN | : 9811066744 |
Download Mitochondrial DNA and Diseases Book in PDF, ePub and Kindle
The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.
| Author | : Carlos M. Palmeira |
| Publisher | : Humana |
| Total Pages | : 318 |
| Release | : 2021-06-08 |
| Genre | : Science |
| ISBN | : 9781071614327 |
Download Mitochondrial Regulation Book in PDF, ePub and Kindle
This fully updated edition explores the different pathways that converge into the regulation of mitochondrial function. The book integrates mitochondria with other cellular components, discussing the dynamic properties of mitochondria with an emphasis on how these processes respond to signaling events and how they affect cellular metabolism. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mitochondrial Regulation: Methods and Protocols, Second Edition is an ideal guide for advanced undergraduates, graduates, postgraduates, and beginning researchers in the areas of molecular and cellular biology, biochemistry, and bioenergetics.
| Author | : Lee-Jun C. Wong |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 364 |
| Release | : 2012-09-18 |
| Genre | : Medical |
| ISBN | : 1461437229 |
Download Mitochondrial Disorders Caused by Nuclear Genes Book in PDF, ePub and Kindle
Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.
| Author | : Peter Sutovsky |
| Publisher | : Springer |
| Total Pages | : 126 |
| Release | : 2019-05-09 |
| Genre | : Science |
| ISBN | : 3030045706 |
Download Cellular and Molecular Basis of Mitochondrial Inheritance Book in PDF, ePub and Kindle
This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
| Author | : Patrick F. Chinnery |
| Publisher | : Cambridge University Press |
| Total Pages | : 229 |
| Release | : 2018-05-17 |
| Genre | : Medical |
| ISBN | : 0521132983 |
Download Clinical Mitochondrial Medicine Book in PDF, ePub and Kindle
This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.
| Author | : Claude Desnuelle |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 314 |
| Release | : 2013-12-01 |
| Genre | : Medical |
| ISBN | : 2817809297 |
Download Mitochondrial Disorders Book in PDF, ePub and Kindle
The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of a century, thanks to W. King Engel's "ragged-red fibres" as convenient markers for mitochondrial pathology, numerous papers described clinical, morphological, and biochemical features of "mitochondrial myopathies." In 1988 the discovery of mutations in mitochondrial DNA led to an explosive expansion of research into mitochondrial disorders. Throughout the 1990s the rapid identification of multiple mitochondrial gene defects associated with clinically diverse disorders has left practitioners puzzled about diagnosing such heterogeneous and complex syndromes. Through updated data, this book discusses now what Luft aptly called "mitochondrial medicine." In so doing, it considers the pivotal role of mitochondria in drug sensitivity, their key roles in ageing, apoptosis, and neurodegeneration along with primary mitochondrial diseases due to mutations in the nuclear genome, in the mitochondrial genome, or in the cross-talk between the two genomes.
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 201 |
| Release | : 2016-04-17 |
| Genre | : Medical |
| ISBN | : 0309388708 |
Download Mitochondrial Replacement Techniques Book in PDF, ePub and Kindle
Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.
| Author | : L. Robert |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 226 |
| Release | : 2014-05-16 |
| Genre | : Medical |
| ISBN | : 3318026530 |
Download Aging Book in PDF, ePub and Kindle
Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.
| Author | : Jaime M. Ross |
| Publisher | : MDPI |
| Total Pages | : 543 |
| Release | : 2018-09-28 |
| Genre | : Electronic book |
| ISBN | : 3038422517 |
Download Mitochondrial Dysfunction in Ageing and Diseases Book in PDF, ePub and Kindle
This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS
