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| Author | : Clifford J. Steer |
| Publisher | : MDPI |
| Total Pages | : 154 |
| Release | : 2020-02-21 |
| Genre | : Science |
| ISBN | : 3039217143 |
Download microRNA Regulation in Health and Disease Book in PDF, ePub and Kindle
MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.
| Author | : Clifford Steer |
| Publisher | : |
| Total Pages | : 154 |
| Release | : 2020 |
| Genre | : Biology (General) |
| ISBN | : 9783039217151 |
Download microRNA Regulation in Health and Disease Book in PDF, ePub and Kindle
MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.
| Author | : Jaishree Paul |
| Publisher | : CRC Press |
| Total Pages | : 231 |
| Release | : 2018-02-19 |
| Genre | : Medical |
| ISBN | : 1351679872 |
Download MicroRNA Book in PDF, ePub and Kindle
This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology.
| Author | : Y-h. Taguchi |
| Publisher | : MDPI |
| Total Pages | : 348 |
| Release | : 2019-04-16 |
| Genre | : Science |
| ISBN | : 3038977683 |
Download Regulatory microRNA Book in PDF, ePub and Kindle
This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.
| Author | : Jaishree Paul |
| Publisher | : CRC Press |
| Total Pages | : 202 |
| Release | : 2018 |
| Genre | : MicroRNA |
| ISBN | : 9781138054837 |
Download MicroRNA Book in PDF, ePub and Kindle
"A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc."
| Author | : Bruce Spiegelman |
| Publisher | : Springer |
| Total Pages | : 108 |
| Release | : 2018-03-07 |
| Genre | : Science |
| ISBN | : 3319727907 |
Download Hormones, Metabolism and the Benefits of Exercise Book in PDF, ePub and Kindle
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
| Author | : Ulf Schmitz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 352 |
| Release | : 2013-02-03 |
| Genre | : Medical |
| ISBN | : 9400755902 |
Download MicroRNA Cancer Regulation Book in PDF, ePub and Kindle
This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.
| Author | : Shane Eakin |
| Publisher | : Murphy & Moore Publishing |
| Total Pages | : 0 |
| Release | : 2023-09-26 |
| Genre | : Medical |
| ISBN | : 9781639877904 |
Download Microrna: Regulation and Clinical Applications Book in PDF, ePub and Kindle
MicroRNAs (miRNAs) are a class of non-coding RNAs found in plants, animals and some viruses. They play a significant role in the regulation of gene expressions and are involved in all physiological processes. These physiological processes include development and differentiation, heart function, metabolism, hemostasis, and apoptosis. The alteration of the miRNA function is associated with some diseases and disorders such as cancer, inherited diseases, cardiovascular diseases and neurodegenerative diseases. Most of the miRNAs are transcribed from DNA sequences to produce primary miRNAs, which are then processed into precursor miRNAs. These finally turn into mature miRNAs. This book provides comprehensive insights into the regulation and clinical applications of microRNA. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of study. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.
| Author | : Milena Rizzo |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2024-04-29 |
| Genre | : Science |
| ISBN | : 9783725808434 |
Download MicroRNAs in Health and Disease Book in PDF, ePub and Kindle
This Special Issue delves into the intricate world of miRNAs as modulators of gene expression regulation. These small non-coding RNAs are at the heart of post-transcriptional modulation of gene activity, affecting a myriad of biological processes. The curated selection of articles within this issue offers insights into the roles of miRNAs in health and disease, emphasizing their potential value as therapeutic targets and biomarkers. Featuring original research and in depth-reviews, this Special Issue covers recent miRNA advancements, detailing their regulatory networks and action mechanisms. It highlights new miRNA-linked therapeutic targets and circulating miRNAs as cell-to-cell communication intermediaries. The issue also examines extracellular miRNAs (ex-miRNAs) and their functions, highlighting their presence in biological fluids and their potential utility in clinical diagnostics and disease monitoring. Challenges in miRNA quantification and technological advances for precise measurement are also discussed. The issue traverses the less-charted territories of miRNA research, such as the discovery of small nucleolar-derived miRNAs and the elucidation of transposable elements as unexpected constituents of the miRNA regulatory network. Overall, this collection showcases the evolving nature of miRNA research, offering valuable perspectives for future scientific inquiry and medical innovation. It reflects the drive to decode gene regulation complexities, providing insights for health professionals and researchers at the forefront of gene regulation research.
| Author | : Daniel Johnston |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : |
Download A Role for MicroRNA-21 in the Regulation of Gastrointestinal Health and Disease Book in PDF, ePub and Kindle
