Micro Nanoscale Engineering Of The Cell Microenvironment PDF Download
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Author | : Daniel Gallego-Perez |
Publisher | : |
Total Pages | : 229 |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Micro/nanoscale Engineering of the Cell Microenvironment Book in PDF, ePub and Kindle
Abstract: The cellular microenvironment/niche plays a significant role in the regulation of a host of physiological and pathophysiological processes. Autonomous signals derived from the intrinsic cell machinery can be inhibited or potentiated by soluble or insoluble factors present in such niche in the form of chemical, structural, and topographical cues. Similarly, specific cell behaviors can be evoked by the same factors even in the absence of intracellular inputs. A normal or aberrant interplay between the cells and their niche could determine for example either the continuation of a regular biological process, or the onset of a disease. Consequently, a better understanding of the mechanisms underlying these cell-microenvironment interactions could help to develop novel therapies for a number of conditions.
Author | : Ali Khademhosseini |
Publisher | : Artech House |
Total Pages | : 647 |
Release | : 2008 |
Genre | : Science |
ISBN | : 1596931493 |
Download Micro and Nanoengineering of the Cell Microenvironment Book in PDF, ePub and Kindle
Supported with 140 illustrations, the volume exhaustively covers the micro- and nano-system technologies involved in developing cell-based bioengineering applications. You get full details on efforts to engineer the soluble and insoluble cell microenvironments, including the latest advances in microfluidic devices, surface patterning, 3D scaffolds, and techniques for engineering cellular mechanical properties and topography.
Author | : Ali Khademhosseini |
Publisher | : |
Total Pages | : 364 |
Release | : 2005 |
Genre | : |
ISBN | : |
Download Nanoscale and Microscale Approaches for Engineering the in Vitro Cellular Microenvironment Book in PDF, ePub and Kindle
(cont.) To easily immobilize cells within channels, poly(ethylene glycol) microstructures were used to capture cells within low shear stress regions. These techniques also allowed for the fabrication of multiphenotype cell arrays. In addition, techniques were developed to control the interaction of cells within hydrogels by controlling the spatial properties of hydrogels.
Author | : Jeffrey M Karp |
Publisher | : William Andrew |
Total Pages | : 395 |
Release | : 2014-05-30 |
Genre | : Science |
ISBN | : 1455731552 |
Download Micro- and Nanoengineering of the Cell Surface Book in PDF, ePub and Kindle
Micro- and Nanoengineering of the Cell Surface explores the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes. The book is accessible for readers across industry, academia, and in clinical settings in multiple disciplines, including materials science, engineering, chemistry, biology, and medicine. Written by leaders in the field, it covers numerous cell surface engineering methods along with their current and potential applications in cell therapy, tissue engineering, biosensing, and diagnosis. The interface of chemistry, materials science, and biology presents many opportunities for developing innovative tools to diagnose and treat various diseases. However, cell surface engineering using chemistry and materials science approaches is a new and diverse field. This book provides a full coverage of the subject, introducing the fundamentals of cell membrane biology before exploring the key application areas. Demystifies the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes Provides a toolkit of micro- and nanoengineering approaches to the manipulation of the cell surface Unlocks the potential of cell surface manipulation for a range of new applications in the fields of in vitro research, cell therapy, tissue engineering, biosensing, and diagnostics
Author | : Yu Sun |
Publisher | : Cambridge University Press |
Total Pages | : 385 |
Release | : 2015-11-12 |
Genre | : Technology & Engineering |
ISBN | : 1316462544 |
Download Integrative Mechanobiology Book in PDF, ePub and Kindle
The first of its kind, this comprehensive resource integrates cellular mechanobiology with micro-nano techniques to provide unrivalled in-depth coverage of the field, including state-of-the-art methods, recent advances, and biological discoveries. Structured in two parts, the first part offers detailed analysis of innovative micro-nano techniques including FRET imaging, electron cryo-microscopy, micropost arrays, nanotopography devices, laser ablation, and computational image analysis. The second part of the book provides valuable insights into the most recent technological advances and discoveries in areas such as stem cell, heart, bone, brain, tumor, and fibroblast mechanobiology. Written by a team of leading experts and well-recognised researchers, this is an essential resource for students and researchers in biomedical engineering.
Author | : Joao Conde |
Publisher | : Elsevier |
Total Pages | : 606 |
Release | : 2018-06-27 |
Genre | : Science |
ISBN | : 0128133406 |
Download Handbook of Nanomaterials for Cancer Theranostics Book in PDF, ePub and Kindle
Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments
Author | : Ying Deng |
Publisher | : Woodhead Publishing |
Total Pages | : 482 |
Release | : 2017-10-17 |
Genre | : Technology & Engineering |
ISBN | : 0081009801 |
Download Functional 3D Tissue Engineering Scaffolds Book in PDF, ePub and Kindle
In order to grow replacement tissues, 3D scaffolds are widely used as a template for tissue engineering and regeneration. These scaffolds, which are typically ‘seeded’ with cells, support the growth of new tissues. However, in order to achieve successful tissue growth, the scaffold must meet specific requirements and are often ‘functionalized’ to accentuate particular properties. Functional 3D tissue engineering scaffolds: materials, technologies, and applications, is a comprehensive review of functional 3D scaffolds, providing information on the fundamentals, technologies, and applications. Part 1 focuses on the fundamentals of 3D tissue scaffolds, examining information on materials, properties, and trends. Part 2 discusses a wide range of conventional technologies for engineering functional 3D scaffolds, leading the way to a discussion on CAD and advanced technologies for functional 3D scaffold engineering. Chapters in part 3 study methods for functionalizing scaffolds to support a variety of in vivo functions whilst the final set of chapters provides an important review of the most significant applications of functional 3D scaffolds within tissue engineering. This book is a valuable resource for biomaterial scientists and biomedical engineers in academia and industry, with interests in tissue engineering and regenerative medicine. Provides a self-contained work for the field of biomaterials and tissue engineering Discusses all the requirements a scaffold must meet and a wide range of strategies to create them Highlights significant and successful applications of functional 3D scaffolds
Author | : Jeffrey T Borenstein |
Publisher | : Elsevier |
Total Pages | : 396 |
Release | : 2018-09-12 |
Genre | : Science |
ISBN | : 0128136723 |
Download Microfluidic Cell Culture Systems Book in PDF, ePub and Kindle
Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.
Author | : David Yash Fozdar |
Publisher | : |
Total Pages | : 466 |
Release | : 2009 |
Genre | : |
ISBN | : |
Download Nanoengineering of Surfaces to Modulate Cell Behavior Book in PDF, ePub and Kindle
Promising strategies for treating diseases and conditions like cancer, tissue necrosis from injury, congenital abnormalities, etc., involve replacing pathologic tissue with healthy tissue. Strategies devoted to the development of tissue to restore, maintain, or improve function is called tissue engineering. Engineering tissue requires three components, cells that can proliferate to form tissue, a microenvironment that nourishes the cells, and a tissue scaffold that provides mechanical stability, controls tissue architecture, and aids in mimicking the cell's natural extracellular matrix (ECM). Currently, there is much focus on designing scaffolds that recapitulate the topology of cells' ECM, in vivo, which undoubtedly wields structures with nanoscale dimensions. Although it is widely thought that sub-microscale features in the ECM have the greatest vii impact on cell behavior relative to larger structures, interactions between cells and nanostructures surfaces is not well understood. There have been few comprehensive studies elucidating the effects of both feature dimension and geometry on the initial formation and growth of the axons of individual neurons. Reconnecting the axons of neurons in damaged nerves is vital in restoring function. Understanding how neurons react with nanopatterned surfaces will advance development of optimal biomaterials used for reconnecting neural networks Here, we investigated the effects of micro- and nanostructures of various sizes and shape on neurons at the single cell level. Compulsory to studying interactions between cells and sub-cellular structures is having nanofabrication technologies that enable biomaterials to be patterned at the nanoscale. We also present a novel nanofabrication process, coined Flash Imprint Lithography using a Mask Aligner (FILM), used to pattern nanofeatures in UV-curable biomaterials for tissue engineering applications. Using FILM, we were able to pattern 50 nm lines in polyethylene glycol (PEG). We later used FILM to pattern nanowells in PEG to study the effect of the nanowells on the behavior preadipocytes (PAs). Results of our cell experiments with neurons and PAs suggested that incorporating micro- and nanoscale topography on biomaterial surfaces may enhance biomaterials' ability to constrain cell development. Moreover, we found the FILM process to be a useful fabrication tool for tissue engineering applications.
Author | : David E. Reisner |
Publisher | : CRC Press |
Total Pages | : 587 |
Release | : 2011-08-25 |
Genre | : Medical |
ISBN | : 143980463X |
Download Bionanotechnology II Book in PDF, ePub and Kindle
The impact and importance of nanotechnology continues to grow, and nanomedicine and biotechnology have become areas of increased development. Biomedical engineers who work with biological processes and structures must have a deeply rooted understanding of the role of bionanotechnology, a rapidly evolving sector of the nanotechnology field. Bionanotechnology II: Global Prospects, a follow-up to the editor’s highly successful first volume, contains 26 entirely new contributions that provide a broad survey of research shaping this critical field. With coverage of technical and nontechnical areas, the book offers representative reporting on a wide variety of activity from around the world. It discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nanobiomaterials. Topics discussed include: Emerging microscale technologies Bionanotech-based water treatment Tissue engineering and drug delivery Antimicrobial nanomaterials in the textile industry Bionanotechnology applications in plants and agriculture With contributions from researchers in Israel, Egypt, Iran, Jordan, Singapore, South Africa, Turkey, Thailand, Argentina, the United Kingdom, and the United States, this volume presents a worldwide perspective on some of the critical areas shaping bionanotechnology today.