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Metallothioneins in Normal and Cancer Cells

Metallothioneins in Normal and Cancer Cells
Author: Piotr Dziegiel
Publisher: Springer
Total Pages: 126
Release: 2016-02-04
Genre: Science
ISBN: 3319274724

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This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.


Metallothionein III

Metallothionein III
Author: Kazuo T. Suzuki
Publisher: Birkhauser
Total Pages: 504
Release: 1993
Genre: Medical
ISBN:

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Zinc and Prostate Cancer

Zinc and Prostate Cancer
Author: Hua Wei (Ph.D.)
Publisher:
Total Pages: 298
Release: 2009
Genre:
ISBN:

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Normal human prostate epithelial cells accumulate high levels of zinc. In contrast, a dramatically decrease in zinc levels is considered a hallmark of prostate cancer. Restoring zinc in prostate cancer cells results in cells apoptosis. The objectives of this study are: 1) to study the effect of zinc on gene expression profile in normal and malignant prostate cells; 2) to determine the expression of metallothioneins (MTs) in response to zinc in normal and malignant prostate cells and tissues; 3) to investigate and characterize the synergistic inhibotory effect of zinc and a chemotherapeutic reagent sulforaphane (SFN) on prostate cancer cell growth...


Metallothioneins in Biochemistry and Pathology

Metallothioneins in Biochemistry and Pathology
Author: Paolo Zatta
Publisher: World Scientific
Total Pages: 335
Release: 2008
Genre: Medical
ISBN: 9812778934

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Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.


Chromosomal Instability in Cancer Cells

Chromosomal Instability in Cancer Cells
Author: B. Michael Ghadimi
Publisher: Springer
Total Pages: 228
Release: 2015-09-16
Genre: Medical
ISBN: 331920291X

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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.


Cancer Drug Resistance

Cancer Drug Resistance
Author: Beverly A. Teicher
Publisher: Springer Science & Business Media
Total Pages: 611
Release: 2007-11-09
Genre: Medical
ISBN: 1597450359

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Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.


Vitamin D

Vitamin D
Author: Adrian F. Gombart
Publisher: CRC Press
Total Pages: 457
Release: 2012-11-21
Genre: Medical
ISBN: 1439850216

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Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. F


Dietary Phytochemicals

Dietary Phytochemicals
Author: Chukwuebuka Egbuna
Publisher: Springer Nature
Total Pages: 262
Release: 2021-08-20
Genre: Science
ISBN: 3030729990

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This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.


Metallothionein II

Metallothionein II
Author: J.H. Kägi
Publisher: Birkhäuser
Total Pages: 723
Release: 2014-03-27
Genre: Science
ISBN: 3034867840

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Comprehensive Toxicology

Comprehensive Toxicology
Author:
Publisher: Elsevier
Total Pages: 8639
Release: 2017-12-01
Genre: Science
ISBN: 0081006128

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Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts