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| Author | : Yuelin Zhang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 154 |
| Release | : 2022-01-18 |
| Genre | : Science |
| ISBN | : 2889740633 |
| Author | : Hartmut Geiger |
| Publisher | : Springer |
| Total Pages | : 357 |
| Release | : 2015-07-06 |
| Genre | : Science |
| ISBN | : 370911232X |
Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.
| Author | : Surajit Pathak |
| Publisher | : Academic Press |
| Total Pages | : 322 |
| Release | : 2021-03-17 |
| Genre | : Science |
| ISBN | : 0128204133 |
Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe
| Author | : Lucas G. Chase |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 458 |
| Release | : 2012-12-12 |
| Genre | : Science |
| ISBN | : 1627032002 |
Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
| Author | : Masaki Ieda |
| Publisher | : Springer |
| Total Pages | : 274 |
| Release | : 2017-10-27 |
| Genre | : Medical |
| ISBN | : 3319561065 |
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
| Author | : Lisa M. Stukenborg |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2022 |
| Genre | : Cytology |
| ISBN | : |
Despite our best efforts to avoid growing older, aging is an inevitable phenomenon that affects all living organisms. The aging process results from normal biological processes that are necessary for maintaining cellular homeostasis, including protein translation and regulation, lipid and nucleotide biosynthesis, nuclear maintenance and chromatin modifications. Over time, cells begin to accumulate damage, enter a unique state known as senescence, disrupting their functionality and thereby contributing to a reduction in organismal lifespan. One of the hallmarks of senescence is an irreversible arrest of the cell cycle resulting in cells which are no longer able to proliferate. Since its discovery, senescence in somatic cells has been well defined, but there are still limitations of our knowledge regarding senescence in stem cells, however, a progressive decline in adult stem cell function is a feature of aged tissues and contributes to multiple age-related diseases. Of particular interest are bone marrow mesenchymal stem cells, also known as bone marrow stromal cells (BMSCs), which are multipotent and have significant therapeutic potential. In this study, we aimed to understand senescence in human bone-marrow mesenchymal stem cells. In addition, we examined the impact of inhibiting the mechanistic/mammalian target of rapamycin (mTOR), using rapamycin, on senescence in BMSCs. We found that stem cells undergo senescence similarly to somatic cells, but also have unique features that have not yet been reported. Due to the implications of senescence in various diseases, this research helps shed light on the role of stem cells during organismal aging.
| Author | : Kursad Turksen |
| Publisher | : Springer Nature |
| Total Pages | : 195 |
| Release | : 2021-08-26 |
| Genre | : Science |
| ISBN | : 3030790584 |
Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the thirteenth volume of a continuing series.
| Author | : Yaoliang Tang |
| Publisher | : Academic Press |
| Total Pages | : 287 |
| Release | : 2015-09-02 |
| Genre | : Science |
| ISBN | : 0128004975 |
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
| Author | : Fiona Macniesia Thomas |
| Publisher | : |
| Total Pages | : 142 |
| Release | : 2019 |
| Genre | : Human cell culture |
| ISBN | : |
| Author | : Miranda A. Farage |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1255 |
| Release | : 2009-12-02 |
| Genre | : Medical |
| ISBN | : 3540896554 |
This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.
